초록

A heart preservation chamber is disclosed which comprises a housing, an inclined trough support surface, and inlet and outlet fluid connections for the major heart blood vessels.

대표청구항 ▼

What is claimed is: 1. A heart preservation apparatus comprising: a housing defining a chamber; an inclined trough, having a concave cross-sectional shape along an axis of the chamber, said trough having an upper end and a lower end, to support a heart between the upper and lower ends of the inclin

What is claimed is: 1. A heart preservation apparatus comprising: a housing defining a chamber; an inclined trough, having a concave cross-sectional shape along an axis of the chamber, said trough having an upper end and a lower end, to support a heart between the upper and lower ends of the inclined trough; and a connector in fluid communication with the heart and coupled to the housing at the upper end of the inclined trough and coupled to the aorta of the heart in a manner placing tension on the aorta to maintain competency of the aortic valve within the heart. 2. A heart preservation apparatus according to claim 1 wherein the inclined trough is inclined to an angle between about 10 degrees and about 80 degrees. 3. A heart preservation apparatus according to claim 1 wherein the inclined trough is inclined to an angle of about 30 degrees. 4. A heart preservation apparatus according to claim 1 wherein the inclined trough supports between 10% and 90% of the heart's weight. 5. A heart preservation apparatus according to claim 1 further comprising at least one additional connector, wherein the at least one additional connector is configured to be connected to at least one vessel selected from a group consisting of: a pulmonary artery and a pulmonary vein. 6. A heart preservation apparatus according to claim 5 wherein the at least one additional connector configured to be connected to the pulmonary artery connects to a lower end of the inclined trough. 7. A heart preservation apparatus according to claim 5 wherein the at least one additional connector configured to be connected to the pulmonary vein connects to an upper end of the inclined trough. 8. A heart preservation apparatus according to claim 1 further comprising a cover which, when in a closed position, combines with the housing to provide a sterile sealed enclosure. 9. A heart preservation apparatus according to claim 1 wherein the housing is made from a biocompatible polymer. 10. A heart preservation apparatus according to claim 1 wherein the at least one connector connects through a wall of the chamber to a perfusion circuit. 11. A heart preservation apparatus according to claim 1 wherein the concave cross-sectional shape of the inclined trough is v-shaped. 12. A heart preservation apparatus according to claim 1 wherein the concave cross-sectional shape of the inclined trough is u-shaped. 13. A heart preservation apparatus according to claim 1 wherein the inclined trough is defined by at least one wall that has an upper and a lower end-and wherein the at least one connector is coupled to the at least one wall at or proximal to the upper end of the wall. 14. A heart preservation apparatus according to claim 1 wherein the housing is defined by at least one wall that has an upper and a lower end and wherein the at least one-connector is coupled to the at least one wall at or proximal to the upper end of the wall. 15. A heart preservation apparatus according to claim 1 wherein the housing is at least partially transparent. 16. A heart preservation apparatus, comprising: a housing defining a chamber; an inclined trough within the chamber having a concave cross-sectional shape to support a heart within the chamber, the inclined trough having an upper end and a lower end; and a cannula configured to be coupled to an aorta of the heart supported by the inclined trough and coupled to the housing at the upper end of the inclined trough to align the aorta-to-apex axis of the heart with an axis of the inclined trough and to place tension on the aorta to maintain competency of an aortic valve within the heart. 17. A heart preservation apparatus according to claim 16 wherein the housing is at least partially transparent. 18. A heart preservation apparatus according to claim 16 wherein the inclined trough is inclined to an angle of (i) about 10 degrees and about 80 degrees or (ii) about 30 degrees. 19. A heart preservation apparatus according to claim 16 further comprising at least one additional cannula, wherein the at least one additional cannula is configured to be connected to at least one vessel selected from a group consisting of: a pulmonary artery and a pulmonary vein. 20. A heart preservation apparatus according to claim 19 wherein the at least one additional cannula configured to be connected to the pulmonary artery connects to a lower end of the inclined trough and wherein the at least one additional cannula configured to be connected to the pulmonary vein connects to an upper end of the inclined trough. 21. A heart preservation apparatus according to claim 16 further comprising a cover which, when in a closed position, combines with the housing to provide a sterile sealed enclosure. 22. A heart preservation apparatus according to claim 16 wherein the concave cross-sectional shape of the inclined trough is v-shaped or u-shaped. 23. A heart preservation apparatus comprising: a housing defining a chamber; an inclined trough, having a concave cross-sectional shape along an axis of the chamber, said trough having an upper end and a lower end, to support a heart between the upper and lower ends of the inclined trough; and a connector coupled to the housing proximal to the upper end of the inclined trough and coupled to the aorta of the heart to align the aorta-to-apex axis of the heart with an axis of the inclined trough, in a manner placing tension on the aorta while in fluid communication with the heart to maintain competency of the aortic valve within the heart. 24. A heart preservation apparatus according to claim 23 wherein the housing is at least partially transparent. 25. A heart preservation apparatus according to claim 23 wherein the inclined trough is inclined to an angle between about 10 degrees and about 80 degrees. 26. A heart preservation apparatus according to claim 23 wherein the inclined trough is inclined to an angle of about 30 degrees. 27. A heart preservation apparatus according to claim 23 wherein the inclined trough supports between 10% and 90% of the heart's weight. 28. A heart preservation apparatus according to claim 23 further comprising at least one additional connector, wherein the at least one additional connector is configured to be connected to at least one vessel selected from a group consisting of: a pulmonary artery and a pulmonary vein. 29. A heart preservation apparatus according to claim 28 wherein the at least one additional connector configured to be connected to the pulmonary artery connects to a lower end of the inclined trough. 30. A heart preservation apparatus according to claim 28 wherein the at least one additional connector configured to be connected to the pulmonary vein connects to an upper end of the inclined trough. 31. A heart preservation apparatus according to claim 23 further comprising a cover which, when in a closed position, combines with the housing to provide a sterile sealed enclosure. 32. A heart preservation apparatus according to claim 23 wherein the housing is made from a biocompatible polymer. 33. A heart preservation apparatus according to claim 23 wherein the at least one connector connects through a wall of the chamber to a perfusion circuit. 34. A heart preservation apparatus according to claim 23 wherein the concave cross-sectional shape of the inclined trough is v-shaped. 35. A heart preservation apparatus according to claim 23 wherein the concave cross-sectional shape of the inclined trough is u-shaped. 36. A heart preservation apparatus according to claim 23 wherein the inclined trough is defined by at least one wall at the upper end of the inclined trough and wherein the connector is coupled to the at least one wall. 37. A heart preservation apparatus according to claim 23 wherein the housing is defined by at least one wall at the upper end of the inclined trough and wherein the connector is coupled to the at least one wall.