Spectroscopic cross-channel method and apparatus for improved optical measurements of tissue
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-006/00
A61B-005/00
출원번호
UP-0262403
(2002-09-30)
등록번호
US-7613504
(2009-11-16)
발명자
/ 주소
Rowe, Robert K.
출원인 / 주소
Lumidigm, Inc.
대리인 / 주소
Townsend, Townsend & Crew LLP
인용정보
피인용 횟수 :
7인용 특허 :
210
초록▼
According to the invention, a sampling system for spectroscopic measurements of a biological sample is disclosed. The sampling system includes a plurality of illumination points, a plurality of detection points, a memory, and a processor. Each of the plurality of illumination points is involved in a
According to the invention, a sampling system for spectroscopic measurements of a biological sample is disclosed. The sampling system includes a plurality of illumination points, a plurality of detection points, a memory, and a processor. Each of the plurality of illumination points is involved in at least two measurements of illumination through the biological sample. Each of the plurality of detection points is involved in at least two measurements of illumination through the biological sample. The memory stores a plurality of measurements. The processor determines a value from the plurality of measurements that is related to the biological sample.
대표청구항▼
What is claimed is: 1. A sampling system for spectroscopic measurements of a biological sample, the sampling system comprising: a plurality of illumination points; a plurality of detection points, wherein: each of the plurality of illumination points is involved in at least two measurements of illu
What is claimed is: 1. A sampling system for spectroscopic measurements of a biological sample, the sampling system comprising: a plurality of illumination points; a plurality of detection points, wherein: each of the plurality of illumination points is involved in at least two measurements of illumination through the biological sample, and each of the plurality of detection points is involved in at least two measurements of illumination through the biological sample; a memory for storing a plurality of measurements, each of the measurements including information defining a combination of a particular one of the plurality of illumination points and a particular one of the plurality of detection points involved in the each of the measurements; and a processor configured to determine a value from the plurality of measurements that is related to the biological sample by compensating for interface noise terms from the combinations of particular ones of the plurality of illumination points and particular ones of the plurality of detection points. 2. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein the value is compared with other values to determine characteristics of the biological sample. 3. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein the value is compared with other values to authenticate an identity belonging to the biological sample. 4. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein the value is compared with a threshold to determine characteristics of the biological sample. 5. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein the value is compared with a threshold to authenticate an identity belonging to the biological sample. 6. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein the processor explicitly solves for the value. 7. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein the plurality of illumination points numbers two. 8. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein the plurality of detection points numbers two. 9. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein: the plurality of illumination points includes a first illumination point and a second illumination point; the first illumination point has a similar spectral luminescence specification than the second illumination point. 10. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein the value is used in a biometric determination. 11. The sampling system for spectroscopic measurements of the biological sample as recited in claim 10, wherein said biometric determination is at least one of the following: a one-to-many identification, a one-to-one identity verification, a sample liveness verification, a sample authenticity verification, a gender estimation, and an age estimation. 12. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein the value represents an analyte measurement. 13. The sampling system for spectroscopic measurements of the biological sample as recited in claim 12, wherein the analyte measurement is of at least one of: glucose, alcohol, and hemoglobin. 14. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein the value relates to a classification of physiological state of the tissue. 15. The sampling system for spectroscopic measurements of the biological sample as recited in claim 14, wherein the classification of physiological state of the tissue is a determination of the presence of cancer. 16. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein at least one of the plurality of detection points receives illumination from each of the plurality of illumination points in a manner that allows the illumination from each of the first and second illumination points to be separately analyzed. 17. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein the plurality of illumination points are illuminated by using an encoding pattern. 18. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein at least one of the plurality of detection points includes a discrete detector element. 19. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein at least some of the plurality of detection points are arranged in a linear detector array. 20. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein at least some of the plurality of detection points are arranged in a two-dimensional detector array. 21. The sampling system for spectroscopic measurements of the biological sample as recited in claim 1, wherein the plurality of illumination points include solid-state electro-optical components. 22. The sampling system for spectroscopic measurements of the biological sample as recited in claim 21, wherein the solid-state electro-optical components include at least one of: a light emitting diode, a laser diode, a vertical cavity surface emitting laser, and a quantum dot laser. 23. A method of performing spectroscopic determinations on a biological sample, the method comprising steps of: providing a plurality of illumination points; providing a plurality of detection points; measuring illumination incident on each of the plurality of detection points a plurality of times, wherein the measuring steps produce a plurality of measurements, each of the measurements including information defining a combination of a particular one of the plurality of illumination points and a particular one of the plurality of detection points involved in the each of the measurements; and determining a value for the biological sample from the plurality of measurements, comprising compensating for interface noise terms from the combinations of particular ones of the plurality of illumination points and particular ones of the plurality of detection points. 24. The method of performing spectroscopic determinations on the biological sample as recited in claim 23, further comprising a step of analyzing the value in a biometric determination. 25. The method of performing spectroscopic determinations on the biological sample as recited in claim 24, wherein said biometric determination is at least one of: a one-to-many identification, a one-to-one identity verification, a sample liveness verification, a sample authenticity verification, a gender estimation, and an age estimation. 26. The method of performing spectroscopic determinations on the biological sample as recited in claim 23, wherein the value relates to an analyte measurement. 27. The method of performing spectroscopic determinations on the biological sample as recited in claim 26, wherein the analyte measurement is of at least one of: glucose, alcohol, and hemoglobin. 28. The method of performing spectroscopic determinations on the biological sample as recited in claim 23, wherein the determining step includes performing a classification algorithm. 29. The method of performing spectroscopic determinations on the biological sample as recited in claim 28, wherein the classification algorithm includes at least one of: a discriminant analysis, a clustering analysis, a partial least squares calculation, a regression, a neural network, a classification tree, and a support vector machine. 30. The method of performing spectroscopic determinations on the biological sample as recited in claim 23, wherein the determining step includes performing a quantitative estimation algorithm. 31. The method of performing spectroscopic determinations on the biological sample as recited in claim 30, wherein said quantitative estimation algorithm includes at least one of: a partial least squares calculation, a multiple least squares, regression, and a neural network. 32. A computer-readable medium having computer-executable instructions for performing the computer-implementable method for performing spectroscopic determinations on the biological sample as recited of claim 23. 33. A sampler for spectroscopic measurements of a biological sample, the sampler comprising: a first illumination point that illuminates at least two detection points with measurable radiation; a second illumination point that illuminates said at least two detection points with measurable radiation; a first of said at least two detection points that receives measurable radiation from said first and second illumination points; a second of said at least two detection points that receives measurable radiation from said first and second illumination points, wherein the first illumination point, the second illumination point, the first detection point, the second detection point are configured to operatively engage the biological sample; and a controller in communication with the first and second illumination points and in communication with the first and second detection points to generate a plurality of measurements, each of the measurements including information defining a combination of a particular one of the plurality of illumination points and a particular one of the plurality of detection points involved in the each of the measurements, and to determine a value from the plurality of measurements that is related to the biological sample by compensating for interface noise terms from the combinations of particular ones of the plurality of illumination points and particular ones of the plurality of detection points. 34. The sampler for spectroscopic measurements of the biological sample as recited in claim 33, wherein at least one of the first and second detection points receives illumination from each of the first and second illumination points in a manner that allows the illumination from each of the first and second illumination points to be separately analyzed. 35. The sampler for spectroscopic measurements of the biological sample as recited in claim 33, wherein at least one of the first and second detection points are illuminated by using an encoding pattern. 36. The sampler for spectroscopic measurements of the biological sample as recited in claim 33, wherein at least one of the first and second detection points includes a discrete detector element. 37. The sampler for spectroscopic measurements of the biological sample as recited in claim 33, wherein at least one of the first and second detection points is arranged in a linear detector array. 38. The sampler for spectroscopic measurements of the biological sample as recited in claim 33, wherein at least one of the first and second detection points are arranged in a two-dimensional detector array. 39. The sampler for spectroscopic measurements of the biological sample as recited in claim 33, wherein at least one of the first and second illumination points includes a solid-state electro-optical component. 40. The sampler for spectroscopic measurements of the biological sample as recited in claim 39, wherein the solid-state electro-optical component includes at least one of: a light emitting diode, a laser diode, a vertical cavity surface emitting laser and a quantum dot laser.
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Rowe, Robert K.; Miller, William A.; Ge, Nanxiang; Robinson, Mark Ries, Apparatus and method for identification of individuals by near-infrared spectrum.
Strobl Karlheinz (Los Angeles CA) Bigio Irving J. (Los Alamos NM) Loree Thomas R. (Santa Fe NM), Apparatus and method for spectroscopic analysis of scattering media.
Rowe, Robert K.; Robinson, Mark Ries; Perella, Steve L.; Landesman, Roxanne N., Apparatus and method of biometric identification or verification of individuals using optical spectroscopy.
Sodickson Lester ; Scharlack Ronald S., Apparatus and methods for the analytical determination of sample component concentrations that account for experimenta.
Zeng Haishan,CAX ; Lui Harvey,CAX ; MacAulay Calum,CAX ; Palcic Branko,CAX ; McLean David I.,CAX, Apparatus and methods relating to optical systems for diagnosis of skin diseases.
Woodriff Ray A. (521 W. Grant St. Bozeman MT 59715) Woodriff Daniel T. (2308 - 10th St. Monroe WI 53566), Background correction in spectro-chemical analysis.
Messerschmidt Robert G. (Westport CT) Sting Donald W. (New Canaan CT), Blocker device for eliminating specular reflectance from a diffuse reflection spectrum.
Mendelson Yitzhak (Worcester MA) Harjunmaa Hannu (Holden MA) Wang Yi (Worcester MA) Gross Brian D. (Worcester MA), Blood constituent determination based on differential spectral analysis.
Milosevic Milan (Croton Dam Rd. Fishkill NY) Harrick Nicolas J. (Croton Dam Rd. Ossining NY 10562), Collecting hemispherical attachment for spectrophotometry.
Maruo Katsuhiko,JPX ; Shimizu Keisuke,JPX ; Oka Masami,JPX, Device for non-invasive determination of a glucose concentration in the blood of a subject.
Bowker J. Kent ; Lubard Stephen C. ; Wartman John M. ; Bolton Clive ; Miller Stephen G., Economical skin-pattern-acquisition and analysis apparatus for access control, systems controlled thereby.
Harjunmaa Hannu (Holden MA) Mendelson Yitzhak (Worcester MA) Wang Yi (Worcester MA), Electromagnetic method and apparatus to measure constituents of human or animal tissue.
Keshaviah Prakash (Plymouth MN) Ebben James P. (Hudson WI) Emerson Paul F. (Minnetonka MN) Luhring David A. (Savage MN), Hemodialysis monitoring system for hemodialysis machines.
Toyoda Haruyoshi,JPX ; Kobayashi Yuuji,JPX ; Mukohzaka Naohisa,JPX, Individual identification apparatus for selectively recording a reference pattern based on a correlation with comparative patterns.
Bertram Albert R. J. (Eindhoven NLX) Coenders Johannes W. (Eindhoven NLX) Span Francis J. (Eindhoven NLX), Interferometer spectrometer having means for varying the optical path length while maintaining alignment.
Sugino Paul S. (Santa Maria CA) Gardner Leland V. (Buellton CA), Intermediate range intensity modification of gaussian beam using optical integration means.
Oehler Oskar (Streulistrasse 24 Zrich CHX) Sourlier David (Zweierstrasse 8 Niederrohrdorf CHX) Fries Alexis (Dietikon CHX), Light collector and its use for spectroscopic purposes.
Price John F. (McCordsville IN) Long James R. (Fishers IN), Method and apparatus for biological fluid analyte concentration measurement using generalized distance outlier detection.
Rohrscheib Mark ; Gardner Craig ; Robinson Mark R., Method and apparatus for non-invasive blood analyte measurement with fluid compartment equilibration.
Small Gary W. (The Plains OH) Arnold Mark (Iowa City IA), Method and apparatus for non-invasive detection of physiological chemicals, particularly glucose.
Mandella Michael J. ; Garrett Mark H. ; Kino Gordon S., Method and apparatus for performing scanning optical coherence confocal microscopy through a scattering medium.
Topping Allen ; Kuperschmidt Vladimir ; Gormley Austin, Method and apparatus for the automated identification of individuals by the nail beds of their fingernails.
Amerov Airat K.,KRX ; Jeon Kye-jin,KRX ; Kim Yoen-joo,KRX ; Yoon Gil-won,KRX, Method and device for noninvasive measurements of concentrations of blood components.
Khuri Raja N. (122 Longmeadow Rd. Greenville NC 27858) Nakhoul Nazih L. (Greenville NC), Method for determining adequacy of dialysis based on urea concentration.
Prokoski Francine J. (1510 Inlet Ct. Reston VA 22090) Coffin Jeffrey S. (Sterling VA) Riedel Robert B. (Great Falls VA), Method for identifying individuals from analysis of elemental shapes derived from biosensor data.
Wu Xiaomao ; Khalil Omar S. ; Jeng Tzyy-Wen ; Yeh Shu-Jen ; Hanna Charles F., Method for improving non-invasive determination of the concentration of analytes in a biological sample.
Purdy David L. (Marion Center PA) Palumbo Perry (New Kingston PA) DiFrancesco Mark (Indiana PA), Method for non-invasive measurement of concentration of analytes in blood using continuous spectrum radiation.
Carman ; Jr. Howard Smith ; Alsmeyer Daniel Charles ; Juarez-Garcia Carlos Humberto ; Garrett Aaron Wayne ; Wilson Bruce Edwin ; Nicely Vincent Alvin, Method for standardizing raman spectrometers to obtain stable and transferable calibrations.
Robinson Mark R. (Albuquerque NM) Ward Kenneth J. (Albuquerque NM) Eaton Robert P. (Albuquerque NM) Haaland David M. (Albuquerque NM), Method of and apparatus for determining the similarity of a biological analyte from a model constructed from known biolo.
Lundsgaard Finn C. (Tastrup DKX) Jensen Niels-Henrik (Farum DKX) Andersen Willy (Espergaerde DKX), Method of photometric in vitro determination of the content of an analyte in a sample of whole blood.
Rowe, Robert K.; Corcoran, Stephen P.; Nixon, Kristin A., Methods and systems for biometric identification of individuals using linear optical spectroscopy.
Block Myron J. (North Salem NH) Sodickson Lester (Waban MA), Methods of minimizing scattering and improving tissue sampling in non-invasive testing and imaging.
Haaland David M. (Albuquerque NM) Jones Howland D. T. (Albuquerque NM) Thomas Edward V. (Albuquerque NM), Multivariate classification of infrared spectra of cell and tissue samples.
Clarke Richard H. (Big Sky MT) Wang Qian (Boston MA), Non-invasive blood analysis by near infrared absorption measurements using two closely spaced wavelengths.
Barnes Russell H. (Columbus OH) Brasch ; Sr. Jimmie W. (Columbus OH) Purdy David L. (Marion Center PA) Lougheed William D. (Toronto CAX), Non-invasive determination of analyte concentration in body of mammals.
Purdy David L. (Marion Center PA) Wiggins Richard L. (Indiana PA) Castro Paul (Indiana PA), Non-invasive determination of analyte concentration using non-continuous radiation.
Barnes Russell H. (Columbus OH) Brasch ; Sr. Jimmie W. (Columbus OH) Purdy David L. (Marion Center PA), Non-invasive determination of glucose concentration in body of patients.
Sterling Bernhard B. ; Braig James R. ; Goldberger Daniel S. ; Kramer Charles E. ; Shulenberger Arthur M. ; Trebino Rick ; King Richard ; Herrera Rogelio O., Non-invasive infrared absorption spectrometer for measuring glucose or other constituents in a human or other body.
Yang Won S. (6-405 ; Donga APT. ; 26 Chang-dong ; Dobong-ku ; Seoul KRX) Kim Yoon O. (865-2 Daerim-dong ; Youngdungpo-ku ; Seoul KRX), Non-invasive method and apparatus for measuring blood glucose concentration.
Rosenthal Robert D. (c/o Futrex ; Inc. ; P.O. Box 2398 Gaithersburg MD 20886) Mastrototaro John J. (6326 Harbridge Rd. Indianapolis IN 46220) Frischmann Joseph K. (6849 Chaucer Ct. Indianapolis IN 46, Non-invasive near-infrared quantitative measurement instrument.
Braig James R. (6147 Chelton Dr. Oakland CA 94611) Goldberger Daniel S. (644 College Ave. Boulder CO 80302), Noninvasive pulsed infrared spectrophotometer.
Shenk John S. (1442 Westerly Pkwy. State College PA 16801) Westerhaus Mark O. (1442 Westerly Pkwy. State College PA 16801), Optical instrument calibration system.
Fateley William G. (Manhattan KS) Rys Andrzej (Manhattan KS) Sobczynski Radoslaw (Manhattan KS), Optical spectrophotometer having a multi-element light source.
Robinson Mark R. (Albuquerque ; both of NM) Haaland David M. (Albuquerque NM) Ward Kenneth J. (Madison WI), Oximeter for reliable clinical determination of blood oxygen saturation in a fetus.
Takatani Setsuo (Hyogo JPX) Awau Kunio (Osaka JPX) Kanda Masahiko (Osaka JPX), Reflection type oximeter for applying light pulses to a body tissue to measure oxygen saturation.
Thomas Edward V. (Albuquerque NM) Robinson Mark R. (Albuquerque NM) Haaland David M. (Albuquerque NM) Alam Mary K. (Albuquerque NM), Reliable noninvasive measurement of blood gases.
Thomas Edward V. (Albuquerque NM) Robinson Mark R. (Albuquerque NM) Haaland David M. (Albuquerque NM) Alam Mary K. (Cedar Crest NM), Reliable noninvasive measurement of blood gases.
Braig James R. (Oakland CA) Goldberger Daniel S. (Boulder CO) Herrera Roger O. (Oakland CA) Sterling Bernhard B. (Danville CA), Self-emission noninvasive infrared spectrophotometer.
Thomas Edward V. (2828 Georgia NE. Albuquerque NM 87110) Robinson Mark R. (1603 Solano NE. Albuquerque NM 87110) Haaland David M. (809 Richmond Dr. SE. Albuquerque NM 87106), Systematic wavelength selection for improved multivariate spectral analysis.
Ridder, Trent D; Johnson, Rob; Abbink, Russell; Maynard, John D, Apparatuses for noninvasive determination of in vivo alcohol concentration using raman spectroscopy.
Wilson, Brian C.; Kim, Anthony Taywon; Valdes, Pablo A.; Paulsen, Keith D.; Roberts, David W., Biopsy device with integrated optical spectroscopy guidance.
Ridder, Trent D; Johnson, Rob; Abbink, Russell; Maynard, John D, Methods for noninvasive determination of in vivo alcohol concentration using Raman spectroscopy.
Ridder, Trent; ver Steeg, Ben; Mills, Mike; Laaksonen, Bentley; McNally, James; Maynard, John; Abbink, Russell, System for noninvasive determination of analytes in tissue.
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