초록 ▼

Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network o

Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels.

대표청구항 ▼

What is claimed is: 1. A hydrogel comprising: a first polymer matrix containing reactive amino moieties; a heterobifunctional modifier comprising a compound of formula: wherein at least one of the "A" or "Z" moieties is covalently bonded to the reactive amino moieties of the first polymer matrix

What is claimed is: 1. A hydrogel comprising: a first polymer matrix containing reactive amino moieties; a heterobifunctional modifier comprising a compound of formula: wherein at least one of the "A" or "Z" moieties is covalently bonded to the reactive amino moieties of the first polymer matrix; and wherein "A" and "Z" are independently a monovalent or divalent organic moiety; wherein at least one of A and Z is a divalent moiety; if A or Z is a monovalent moiety, then A or Z is selected from the group consisting of halo, hydroxy, C1-C24-alkyl, C1-C24-alkenyl, C1-C24-alkynyl, C1-C24-alkoxy, C1-C24-heteroalkyl, C1-C24-heteroalkenyl, C1-C24-heteroalkynyl, cyano-C1-C24-alkyl, a C3-C10-cycloalkyl, C3-C10-cycloalkenyl, C3-C10-cycloalkynyl, C3-C10-cycloheteroalkyl, C3-C10-cycloheteroalkenyl, C3-C10-cycloheteroalkynyl, acyl, acyl-C1-C24-alkyl, acyl-C1-C24-alkenyl, acyl-C1-C24-alkynyl, carboxy, C1-C24-alkylcarboxy, C1-C24-alkenylcarboxy, C1-C24-alkynylcarboxy, carboxy-C1-C24-alkyl, carboxy-C1-C24-alkenyl, carboxy-C1-C24-alkynyl, aryl, aryl-C1-C24-alkyl, aryl-C1-C24-alkenyl, aryl-C1-C24-alkynyl, heteroaryl, heteroaryl-C1-C24-alkyl, heteroaryl-C1-C24-alkenyl, heteroaryl-C1-C24-alkynyl, sulfonate, arylsulfonate, and heteroarylsulfonate; if A or Z is a divalent moiety, then A or Z is independently selected from a divalent equivalent of a monovalent moiety selected from the group consisting of C1-C24-alkyl, C1-C24-alkenyl C1-C24-alkynyl, C1-C24-alkoxy, C1-C24-heteroalkyl, C1-C24-heteroalkenyl, C1-C24-heteroalkynyl, cyano-C1-C24-alkyl, a C3-C10-cycloalkyl, C3-C10-cycloalkenyl, C3-C10-cycloalkynyl, C3-C10-cycloheteroalkyl, C3-C10-cycloheteroalkenyl, C3-C10-cycloheteroalkynyl, acyl, acyl-C1-C24-alkyl, acyl-C1-C24-alkenyl, acyl-C1-C24-alkynyl, carboxy, C1-C24-alkylcarboxy, C1-C24-alkenylcarboxy, C1-C24-alkynylcarboxy, carboxy-C1-C24-alkyl, carboxy-C1-C24-alkenyl, carboxy-C1-C24-alkynyl, aryl, aryl-C1-C24-alkyl, aryl-C1-C24-alkenyl, aryl-C1-C24-alkynyl, heteroaryl, heteroaryl-C1-C24-alkyl, heteroaryl-C1-C24-alkenyl, heteroaryl-C1-C24-alkynyl, sulfonate, arylsulfonate, and heteroarylsulfonate; wherein the "A" moiety and the "Z" moiety are different from one another; wherein only one of A and Z is bound to the first polymer matrix; wherein "m" is an integer of from 2 to 8 and "n" is an integer equal to or greater than 100; and a second polymer matrix that interpenetrates with the first polymer matrix. 2. The hydrogel of claim 1, further comprising a pharmacologically-active agent covalently bonded to one of the "A" or "Z" moieties that is not bonded to the first polymer matrix. 3. The hydrogel of claim 1, where the first polymer matrix is proteinaceous. 4. The hydrogel of claim 1, wherein the first polymer matrix is selected from the group consisting of gelatin, calcium alginate, calcium/sodium alginate, collagen, oxidized regenerated cellulose, carboxymethylcellulose, amino-modified cellulose, and whey protein. 5. The hydrogel of claim 1, wherein the first polymer matrix is selected from the group consisting of gelatin and collagen. 6. The hydrogel of claim 1, wherein the first polymer matrix is cross-linked with a cross-linking reagent. 7. The hydrogel of claim 1, wherein the first polymer matrix is cross-linked with glutaraldehyde. 8. The hydrogel of claim 1, wherein the first polymer matrix further comprises EDTAD moieties bonded to it. 9. The hydrogel of claim 1, wherein "n" is equal to or greater than 200. 10. The hydrogel of claim 1, wherein "n" is equal to or greater than 2,000. 11. The hydrogel of claim 1, wherein "n" is equal to or greater than 20,000. 12. The hydrogel of claim 1, further comprising a pharmacologically-active agent entrained within the hydrogel. 13. The hydrogel of claim 1, further comprising living cells entrained within the hydrogel. 14. The hydrogen of claim 2, wherein the pharmacologically active agent is selected from the group consisting of vulnerary agents, hemostatic agents, antibiotics, antithelmintics, antifungal agents, hormones, anti-inflammatory agents, proteins, polypeptides, oligonucleotides, cytokines, and enzymes. 15. The hydrogel of claim 14, wherein the pharmacologically active agent is a vulnerary agent. 16. The hydrogel of claim 12, wherein the pharmacologically active agent is selected from the group consisting of vulnerary agents, hemostatic agents, antibiotics, antithelmintics antifungal agents, hormones, anti-inflammatory agents, proteins, polypeptides, oligonucleotides, cytokines, and enzymes. 17. The hydrogel of claim 16, wherein the pharmacologically active agent is a vulnerary agent.