Inhalers with extendable/retractable forward member and associated methods of dispensing inhalant substances
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-015/00
A61M-016/00
B05D-007/14
B65D-083/06
출원번호
UP-0052627
(2005-02-07)
등록번호
US-7624733
(2009-12-16)
발명자
/ 주소
Riley, William Myles
Anderson, Sean Derek
Ferris, Bruce Seymour
Rockwell, Paul Gilbert
출원인 / 주소
Oriel Therapeutics, Inc.
대리인 / 주소
Myers Bigel Sibley & Sajovec, P.A.
인용정보
피인용 횟수 :
6인용 특허 :
14
초록▼
Dry powder inhalers for dispensing pharmaceutical grade formulations of inhalable dry powder include: an inhaler housing having a mouthpiece associated therewith; and a slidably extendable forward member that is movable between retracted and extended positions, held by the inhaler housing adjacent t
Dry powder inhalers for dispensing pharmaceutical grade formulations of inhalable dry powder include: an inhaler housing having a mouthpiece associated therewith; and a slidably extendable forward member that is movable between retracted and extended positions, held by the inhaler housing adjacent the mouthpiece. In the extended position, the forward member extends outward a distance beyond a forwardmost portion of the mouthpiece, and in the retracted position, a forwardmost portion of the forward member is positioned rearward of the forwardmost portion of the mouthpiece with an access portion of the mouthpiece accessible by a user.
대표청구항▼
The invention claimed is: 1. A dry powder inhaler for dispensing pharmaceutical grade formulations of inhalable dry powder, comprising: an inhaler housing having a stationary mouthpiece associated therewith, the housing having a longitudinal axis coinciding with a longitudinal axis of the mouthpiec
The invention claimed is: 1. A dry powder inhaler for dispensing pharmaceutical grade formulations of inhalable dry powder, comprising: an inhaler housing having a stationary mouthpiece associated therewith, the housing having a longitudinal axis coinciding with a longitudinal axis of the mouthpiece; a slidably extendable forward member that is movable between retracted and extended positions over an outer surface of the inhaler housing, held by the inhaler housing adjacent the mouthpiece, wherein, in the extended position, the forward member extends outward a distance beyond a forwardmost portion of the mouthpiece, and in the retracted position, a forwardmost portion of the forward member is positioned rearward of the forwardmost portion of the mouthpiece with an access portion of the mouthpiece accessible by a user; a blister package held in the housing, the blister package comprising a plurality of spaced apart sealed blisters thereon; and a blade cartridge with a blade held in the inhaler housing, wherein the movement of the forward member is configured to automatically activate the blade cartridge to cause the blade to move lengthwise across a blister held in a dispensing position in the inhaler to thereby open the blister held in the dispensing position. 2. A dry powder inhaler for dispensing pharmaceutical grade formulations of inhalable dry powder, comprising: an inhaler housing having a mouthpiece associated therewith, the housing having a longitudinal axis coinciding with a longitudinal axis of the mouthpiece; a slidably extendable forward member that is movable between retracted and extended positions over an outer surface of the inhaler housing, held by the inhaler housing adjacent the mouthpiece, wherein, in the extended position, the forward member extends outward a distance beyond a forwardmost portion of the mouthpiece, and in the retracted position, a forwardmost portion of the forward member is positioned rearward of the forwardmost portion of the mouthpiece with an access portion of the mouthpiece accessible by a user; a blister package held in the housing, the blister package comprising a plurality of spaced apart sealed blisters thereon; and a movable blade cartridge configured to hold a blade at a forward portion thereof mounted in the inhaler housing, the movable blade cartridge cooperatively engaged with the forward member to selectively engage at least one target blister during dispensing in response to movement of the forward member. 3. A dry powder inhaler according to claim 2, wherein the inhaler is configured to rotatably index at least one selected blister on the blister package to a dispensing location proximate the mouthpiece in cooperation with the movement of the forward member. 4. A dry powder inhaler for dispensing pharmaceutical grade formulations of inhalable dry powder, comprising: an inhaler housing having a mouthpiece associated therewith, the housing having a longitudinal axis coinciding with a longitudinal axis of the mouthpiece; a slidably extendable forward member that is movable between retracted and extended positions, held by the inhaler housing adjacent the mouthpiece, wherein, in the extended position, the forward member extends outward a distance beyond a forwardmost portion of the mouthpiece, and in the retracted position, a forwardmost portion of the forward member is positioned rearward of the forwardmost portion of the mouthpiece with an access portion of the mouthpiece accessible by a user; a blister package held in the housing, the blister package comprising a plurality of spaced apart sealed blisters thereon; and a movable blade cartridge configured to hold a blade at a forward portion thereof mounted in the inhaler housing, the movable blade cartridge cooperatively engaged with the forward member to selectively engage at least one target blister during dispensing in response to movement of the forward member, wherein the inhaler is configured to rotatably index at least one selected blister on the blister package to a dispensing location proximate the mouthpiece in cooperation with the movement of the forward member, and wherein each blister has a projecting ceiling and a floor defining a blister channel therebetween, the blister channel comprising a dry powder therein. 5. A dry powder inhaler according to claim 4, wherein the blister channels have a width, depth, and length, and wherein the blade is configured to travel in the inhaler substantially horizontally above and across at least a major portion of the length of a respective channel. 6. A dry powder inhaler for dispensing pharmaceutical grade formulations of inhalable dry powder, comprising: an inhaler housing having a stationary mouthpiece associated therewith, the housing having a longitudinal axis coinciding with a longitudinal axis of the mouthpiece; a slidably extendable forward member that is movable between retracted and extended positions over an outer surface of the inhaler housing, held by the inhaler housing adjacent the mouthpiece, wherein, in the extended position, the forward member extends outward a distance beyond a forwardmost portion of the mouthpiece, and in the retracted position, a forwardmost portion of the forward member is positioned rearward of the forwardmost portion of the mouthpiece with an access portion of the mouthpiece accessible by a user; a blister package held in the housing, the blister package comprising a plurality of spaced apart sealed blisters thereon; and a rotatable gear that cooperates with the forward member and the blister package to automatically advance the blister package a desired distance to position a blister in a dispensing position in the inhaler in response to movement of the forward member. 7. A dry powder inhaler according to claim 6, further comprising a pawl that is attached to the forward member and positioned in the inhaler so as to engage the gear and rotate the blister package a predetermined distance to serially advance blisters toward the dispensing position when the forward member is extended outward. 8. A dry powder inhaler according to claim 7, further comprising a locking arm configured to abut a portion of a gear tooth of the gear at a position that is spaced apart from the pawl to inhibit the gear from rotating backward when the forward member is retracted. 9. A dry powder inhaler for dispensing pharmaceutical grade formulations of inhalable dry powder, comprising: an inhaler housing having a mouthpiece associated therewith, the housing having a longitudinal axis coinciding with a longitudinal axis of the mouthpiece; and a slidably extendable forward member that snugly slides over an outer surface of the inhaler housing about a straight travel path between retracted and extended positions, wherein, in the extended position, the forward member extends outward a distance beyond a forwardmost portion of the mouthpiece to enclose the mouthpiece, and in the retracted position, a forwardmost portion of the forward member is positioned rearward of the forwardmost portion of the mouthpiece to expose an access portion of the mouthpiece that is accessible by a user, wherein the inhaler housing has an elongate body with a thin profile defining a pocket-sized inhaler that fits into the pocket of a garment worn by a user, wherein the inhaler comprises at least one thin piezoelectric polymer material layer with conductive selected portions in electrical communication therewith to define at least one active energy releasing vibratory channel. 10. A method of dispensing from an inhaler, comprising: slidably extending a forward member of an inhaler having a stationary mouthpiece outward over an outer surface of an inhaler housing so that the forward member extends a distance beyond a forwardmost portion of the mouthpiece; the housing having a longitudinal axis coinciding with a longitudinal axis of the mouthpiece; slidably retracting the forward member over the outer surface of the inhaler housing so that a forwardmost portion of the forward member resides rearward of the forwardmost portion of the mouthpiece such that an access portion of the mouthpiece is accessible by a user to allow inhalation dispensing of medicament in the inhaler, wherein the retracting step comprises automatically advancing a cutting blade across a portion of a projecting ceiling of an indexed blister in the inhaler responsive to the retraction; and opening the blister by moving the cutting blade in concert with the forward member to thereby open a projecting ceiling of the indexed blister responsive to the retracting step. 11. A method of dispensing from an inhaler, comprising: sliding a forward member of an inhaler having a mouthpiece and a housing, the housing having a longitudinal axis coinciding with a longitudinal axis of the mouthpiece, outward over an outer surface of the inhaler so that the forward member extends a distance beyond a forwardmost portion of the mouthpiece; sliding the forward member inward over the outer surface of the inhaler so that a forwardmost portion of the forward member resides rearward of the forwardmost portion of the mouthpiece to expose the mouthpiece such that an access portion of the mouthpiece is accessible by a user to allow inhalation dispensing of medicament in the inhaler; and automatically indexing a blister on a blister package in the inhaler into a dispensing position in response to at least one of the extending and retracting steps to thereby provide a dose-regulated medicament for inhalation dispensing, wherein the indexing step comprises rotating a gear attached to the blister package to index the blister to a dispensing position. 12. A method according to claim 10, wherein the opening step comprises plowing across the ceiling with a member having a three-dimensional forward edge portion to substantially concurrently open and fold ceiling material as the blade travels across the blister. 13. A method according to claim 10, wherein the opening step comprises slicing a top horizontal portion of the blister ceiling as the blade moves across the ceiling in a direction that is generally aligned with a center axis extending in a length direction of an underlying blister channel. 14. A method of dispensing from an inhaler, comprising: extending a forward member of an inhaler having a mouthpiece and a housing, the housing having a longitudinal axis coinciding with a longitudinal axis of the mouthpiece, outward so that the forward member extends a distance beyond a forwardmost portion of the mouthpiece; and retracting the forward member so that a forwardmost portion of the forward member resides rearward of the forwardmost portion of the mouthpiece such that an access portion of the mouthpiece is accessible by a user to allow inhalation dispensing of medicament in the inhaler, wherein the inhaler comprises a blister package with a plurality of sealed blisters thereon; vibrating a blister during and/or after the retracting step; and releasing dry powder in an opened blister on a blister package comprising a plurality of sealed blisters, wherein the inhaler and/or blisters comprise a piezoelectric polymer material, wherein the vibrating step comprises oscillating the piezoelectric polymer material, and wherein the inspiratory step comprises releasing inhalable dry powder aerosol to the user while the piezoelectric polymer material is vibrating.
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이 특허에 인용된 특허 (14)
Thomas Nilsson SE; Mattias Myrman SE, Continuous dry powder inhaler.
Hodson Peter David (Trowell Park GB3) Smith David Keith (Loughborough GB3) Wass Anthony Charles Lammond (Duddington GB3), Dry powder inhalation device having deagglomeration/aerosolization structure responsive to patient inhalation.
Newhouse Michael T. (436 Queen Street South Hamilton ; Ontario CAX L8N 4A6) Baines W. Douglas (1675 Wedmore Way Mississauga ; Ontario CAX), Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow.
Crowder, Timothy M.; Hickey, Anthony J.; Warden, Jeffrey A., Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages.
Mulhauser Paul (New York NY) Karg Jeffrey (Waldwick NY) Foxen Thomas (Brooklyn NY) Brooks Christopher J. (Glen Head NY), Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same.
Smith Adrian E. ; Burr John D. ; Etter Jeffery W. ; Axford George S. ; Lyons Shirley W. ; Platz Robert M., Method and apparatus for dispersion of dry powder medicaments.
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