최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
---|---|
국제특허분류(IPC7판) |
|
출원번호 | UP-0015313 (2004-12-16) |
등록번호 | US-7632307 (2009-12-24) |
발명자 / 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 22 인용 특허 : 790 |
Embodiments of coatings for implantable medical devices, such as stents, are disclosed. The devices may include at least one structural element having an abluminal side, luminal side, and sidewalls between the abluminal and luminal sides. The coating may include at least two continuous coating layer
Embodiments of coatings for implantable medical devices, such as stents, are disclosed. The devices may include at least one structural element having an abluminal side, luminal side, and sidewalls between the abluminal and luminal sides. The coating may include at least two continuous coating layers. In some embodiments, the luminal side, and all or a majority of the sidewalls are free of at least two of the coating layers.
What is claimed is: 1. A structural element of an implantable medical device, a surface of the structural element comprises an abluminal side, a luminal side, and two sidewalls extending between the abluminal side and the luminal side, wherein the structural element has a coating comprising: a cont
What is claimed is: 1. A structural element of an implantable medical device, a surface of the structural element comprises an abluminal side, a luminal side, and two sidewalls extending between the abluminal side and the luminal side, wherein the structural element has a coating comprising: a continuous first layer disposed above all or a majority of the abluminal side and above a portion of at least one of the sidewalls extending from the abluminal side, wherein the luminal side and other portions of the at least one sidewall are free from the first layer wherein the first layer comprises a polymer; and a continuous second layer covering the first layer such that no portion of the first layer is not covered by the second layer, and wherein the luminal side of the structural element is free from the second layer; wherein the second layer covers a portion of the structural element not covered by the first layer, wherein the first layer is over the portion of the at least one of the sidewalls measured along an axis normal to the portion of the at least one of the sidewalls. 2. The structural element of claim 1, wherein a majority of the sidewalls are free from the first layer and the second layer. 3. The structural element of claim 1, wherein the structural element comprises a second polymer. 4. The structural element of claim 3, wherein the second polymer is biodegradable. 5. The structural element of claim 3, wherein the second polymer is poly(ester amide). 6. The structural element of claim 1, wherein the implantable medical device is a stent. 7. The structural element of claim 1, wherein the structural element comprises a metal. 8. The structural element of claim 1, wherein at least one of the layers is a reservoir layer comprising a substance selected from the group consisting of rapamycin, 40-O-(2-hydroxy)ethyl-rapamycin, 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, 40-O-tetrazole-rapamycin, and a combination thereof. 9. The structural element of claim 1, wherein the second layer is a reservoir layer comprising a pure or substantially pure active agent. 10. The structural element of claim 1, wherein the first layer comprises an active agent dispersed and/or dissolved in the polymer. 11. The structural element of claim 1, wherein the polymer is biodegradable. 12. The structural element of claim 1, wherein the first layer comprises a reservoir layer, and wherein the second layer comprises a topcoat layer, primer layer, and/or biobeneficial layer. 13. The structural element of claim 1, wherein the first layer comprises a topcoat layer, primer layer, and/or biobeneficial layer, and wherein the second layer comprises a reservoir layer. 14. The structural element of claim 1, wherein the second layer comprises poly(ester amide). 15. The structural element of claim 1, wherein the first layer and/or the second layer are strip-shaped such that at least one edge of the first layer and/or at least one edge of the second layer is parallel or substantially parallel to a longitudinal axis of the structural element. 16. The structural element of claim 1, further comprising a continuous third layer covering the second layer such that no portion of the second layer is not covered by the third layer. 17. The structural element of claim 16, wherein the third layer is a biobeneficial coating layer and/or a topcoat layer. 18. The structural element of claim 16, wherein the luminal side of the structural element is free from the third layer. 19. The structural element of claim 16, wherein a majority of the sidewalls are free from the third layer. 20. The structural element of claim 16, wherein the third layer comprises poly(ester amide). 21. The structural element of claim 1, wherein the second layer comprises an active agent dispersed and/or dissolved in a second polymer. 22. The structural element of claim 1, wherein a surface of the structural element below the coating is cavity free. 23. The structural element of claim 1, wherein the second layer does not entirely cover the sidewalls. 24. The structural element of claim 1, wherein the first layer contacts the portion of the at least one of the sidewalls. 25. A structural element of an implantable medical device, a surface of the structural element comprises an abluminal side, a luminal side, and two sidewalls extending between the abluminal side and the luminal side, wherein the structural element has a coating comprising: a continuous first layer disposed above all or a majority of the abluminal side and above a portion of at least one of the sidewalls extending from the abluminal side, wherein the luminal side and other portions of the at least one sidewall are free from the first layer wherein the first layer comprises a polymer; a continuous second layer covering the first layer such that no portion of the first layer is not covered by the second layer, and wherein the luminal side of the structural element is free from the second layer; and a continuous third layer covering the second layer such that no portion of the second layer is not covered by the third layer; wherein the third layer covers a portion of the structural element not covered by the second layer, wherein the first layer is over the portion of the at least one of the sidewalls measured along an axis normal to the portion of the at least one of the sidewalls. 26. The structural element of claim 25, wherein the second and third layers do not entirely cover the sidewalls. 27. The structural element of claim 25, wherein the first layer contacts the portion of the at least one of the sidewalls. 28. A structural element of an implantable medical device, a surface of the structural element comprises an abluminal side, a luminal side, and two sidewalls extending between the abluminal side and the luminal side, wherein the structural element has a coating comprising: a continuous first layer disposed above all or a majority of the abluminal side and above a portion of at least one of the sidewalls extending from the abluminal side, wherein the luminal side and portions of the sidewalls are free from the first layer wherein the first layer comprises a polymer; a continuous second layer covering the first layer such that no portion of the first layer is not covered by the second layer, and wherein the luminal side of the structural element is free from the second layer; a continuous third layer covering the second layer such that no portion of the second layer is not covered by the third layer; a continuous fourth layer covering the third layer such that no portion of the third layer is not covered by the fourth layer; and wherein the first layer is over the portion of the at least one of the sidewalls measured along an axis normal to the portion of the at least one of the sidewalls. 29. The structural element of claim 28, wherein the first layer is disposed above a portion of at least one of the sidewalls. 30. The structural element of claim 28, wherein the second and third layers do not entirely cover the side walls. 31. A structural element of an implantable medical device, a surface of the structural element comprises an abluminal side, a luminal side, and two sidewalls extending between the abluminal side and the luminal side, wherein the structural element has a coating comprising: a continuous first layer disposed above all or a majority of the abluminal side and above a portion of at least one of the sidewalls extending from the abluminal side, wherein the luminal side and portions of the sidewalls are free from the first layer; and a continuous second layer covering a portion of the first layer such that at least a portion of the first layer is not covered by the second layer, the second layer different in composition from the first layer; a continuous third layer covering the second layer such that no portion of the second layer is not covered by the third layer; a continuous fourth layer covering the third layer such that no portion of the third layer is not covered by the fourth layer, wherein the fourth layer is a biobeneficial coating layer that increases biocompatibility of the coating; and wherein the first layer is over the portion of the at least one of the sidewalls measured along an axis normal to the portion of the at least one of the sidewalls.
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.