초록 ▼

The present invention relates to inorganic monolithic mouldings whose surface is coated with physi- or chemisorbed organic polymers, and to processes for the production of materials of this type. The materials according to the invention are highly suitable as sorbents for chromatography, in particul

The present invention relates to inorganic monolithic mouldings whose surface is coated with physi- or chemisorbed organic polymers, and to processes for the production of materials of this type. The materials according to the invention are highly suitable as sorbents for chromatography, in particular for high pressure liquid chromatography of biological materials.

대표청구항 ▼

The invention claimed is: 1. A coated, clad moulding consisting essentially of a porous inorganic monolithic moulding having one side longer than the other(s) and having a cladding on the long side, wherein a free radical initiator is homogeneously distributed on the surface of said moulding before

The invention claimed is: 1. A coated, clad moulding consisting essentially of a porous inorganic monolithic moulding having one side longer than the other(s) and having a cladding on the long side, wherein a free radical initiator is homogeneously distributed on the surface of said moulding before being coated with a polymer applied from a coating solution by impregnation, comprising at least one organic prepolymer or organic monomer and/or oligomer, which organic prepolymer or organic monomer and/or oligomer is precipitated from the coating solution by lowering the solution temperature and which polymer is physisorbed or chemisorbed on the inorganic moulding and bonded to said moulding via initiation, and wherein the polymer coating is stable against NaOH, and wherein all of the pores of the inorganic moulding have inner surfaces uniformly coated by said polymer such that a pore volume of the inorganic moulding is retained in the coated clad moulding. 2. A moulding according to claim 1, wherein the porous inorganic monolithic moulding consists of SiO2. 3. A moulding according to claim 1, wherein the porous inorganic monolithic moulding has a bimodal pore structure with mesopores and macropores. 4. A moulding according to claim 3, wherein said mesopores have a diameter of between about 2 and 100 nm, and said macropores have a mean diameter of greater than 0.1 μm. 5. A moulding according to claim 1, wherein the organic polymer is polystyrene and/or polymethacrylate. 6. A moulding according to claim 1, wherein the organic polymer is physisorbed on the inorganic moulding. 7. A moulding according to claim 1, wherein said moulding is flat. 8. A moulding according to claim 7, wherein said moulding has a thickness of 0.2-20 μm. 9. A moulding according to claim 1, wherein said moulding is columnar and has a diameter of 0.1 cm-5 cm. 10. A moulding according to claim 9, wherein said moulding has a length of 1-30 cm. 11. A moulding according to claim 1, wherein said mouldings comprise an inorganic oxide. 12. A moulding according to claim 11, wherein said inorganic oxide is aluminium oxide, titanium dioxide or silicon dioxide. 13. A moulding according to claim 1, wherein said organic polymer is polystyrene, polymethacrylate, melamine, a polysaccharide, polysiloxane or a derivative or copolymer thereof. 14. A moulding according to claim 1, wherein said organic polymer is a copolymer of tetraalkoxysilane and methyltrialkoxysilane. 15. A moulding according to claim 1, wherein the carbon content of the coated moulding is from 0.97 to 1.05%. 16. A moulding according to claim 1, wherein said moulding is coated with poly(2-hydroxyethyl methacrylate) [P2HEMA], a copolymer of 2-hydroxyethyl methacrylate and ethyl methacrylate [P2HE-E], poly(octadecyl methacrylate) [POMA], or poly(methacrylate) [PEMA]. 17. A moulding according to claim 1, wherein said organic polymer is forced thru said moulding under pressure and afterward the temperature is lowered. 18. A process for the production of a coated, clad porous inorganic monolithic moulding according to claim 1, comprising: a) providing a porous inorganic monolithic moulding, b) impregnating the porous inorganic monolithic moulding from step a) with a coating solution comprising at least one organic prepolymer or organic monomer and/or oligomer, c) coating the moulding, whereby during the coating, the moulding is clad in an impermeable manner, at least on the long sides, with an inert material or stored in an inert solvent and d) washing and drying the moulding from step c) to remove reaction residues and solvent. 19. A process according to claim 18, wherein in step c) the prepolymer or monomer and/or oligomer is precipitated from the coating solution onto the inorganic moulding. 20. A process according to claim 19, wherein the precipitation is carried out by lowering the temperature. 21. A method for the chromatographic separation of at least two substances comprising introducing said substances to a moulding according to claim 1. 22. A method according to claim 21, wherein said chromotography is high pressure liquid chromatography and at least one of said substances is a biological material. 23. A method according to claim 21, wherein at least one of said substances is a protein or nucleic acid.