초록 ▼

Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immuno

Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.

대표청구항 ▼

The invention claimed is: 1. An isolated peptide consisting of one of the amino acid sequences: Leu-Leu-Val-Val-Val-Leu-Gly-Val-Val (Seq. ID No. 5); Arg-Leu-Leu-Gln-Glu-Thr-Glu-Leu-Val (Seq. ID No. 6); Asp-Leu-Ala-Ala-Arg-Asn-Val-Leu-Val (Seq. ID No. 8); Thr-Leu-Ser-Pro-Gly-Lys-Asn-Gly-Val (Seq. ID

The invention claimed is: 1. An isolated peptide consisting of one of the amino acid sequences: Leu-Leu-Val-Val-Val-Leu-Gly-Val-Val (Seq. ID No. 5); Arg-Leu-Leu-Gln-Glu-Thr-Glu-Leu-Val (Seq. ID No. 6); Asp-Leu-Ala-Ala-Arg-Asn-Val-Leu-Val (Seq. ID No. 8); Thr-Leu-Ser-Pro-Gly-Lys-Asn-Gly-Val (Seq. ID No. 10); Asp-Leu-Leu-Glu-Lys-Gly-Glu-Arg-Leu (Seq. ID No. 20); Asp-Leu-Val-Asp-Ala-Glu-Glu-Tyr-Leu (Seq. ID No. 23); or Ile-Leu-Asp-Glu-Ala-Tyr-Val-Met-Ala-Gly-Val (Seq. ID No. 28). 2. An isolated peptide according to claim 1 consisting of the amino acid sequence of Leu-Leu-Val-Val-Val-Leu-Gly-Val-Val (Seq. ID No. 5). 3. An isolated peptide according to claim 1 consisting of the amino acid sequence of Arg-Leu-Leu-Gln-Glu-Thr-Glu-Leu-Val (Seq. ID No. 6). 4. An isolated peptide according to claim 1 consisting of the amino acid sequence of Asp-Leu-Ala-Ala-Arg-Asn-Val-Leu-Val (Seq. ID No. 8). 5. An isolated peptide according to claim 1 consisting of the amino acid sequence of Thr-Leu-Ser-Pro-Gly-Lys-Asn-Gly-Val (Seq. ID No. 10). 6. An isolated peptide according to claim 1 consisting of the amino acid sequence of Asp-Leu-Leu-Glu-Lys-Gly-Glu-Arg-Leu (Seq. ID No. 20). 7. An isolated peptide according to claim 1 consisting of the amino acid sequence of Asp-Leu-Val-Asp-Ala-Glu-Glu-Tyr-Leu (Seq. ID No. 23). 8. An isolated peptide according to claim 1 consisting of the amino acid sequence of Ile-Leu-Asp-Glu-Ala-Tyr-Val-Met-Ala-Gly-Val (Seq. ID No. 28).