Compositions used to enhance the elasticity and/or appearance of tissue are described. The compositions include peptides and/or peptide-like compounds and combinations thereof having low molecular weights and which substantially correspond to sequences found in elastin. The compositions may be appli
Compositions used to enhance the elasticity and/or appearance of tissue are described. The compositions include peptides and/or peptide-like compounds and combinations thereof having low molecular weights and which substantially correspond to sequences found in elastin. The compositions may be applied to human skin in a cosmetic or therapeutic formulation and may result in enhanced elasticity and turgor of the skin.
대표청구항▼
What is claimed is: 1. A composition useful in treating mammalian tissue, said composition being comprised of SEQ ID 12. 2. The composition of claim 1, wherein the peptide is soluble in an aqueous solution. 3. The composition of claim 2, wherein the peptide is at a therapeutically effective con
What is claimed is: 1. A composition useful in treating mammalian tissue, said composition being comprised of SEQ ID 12. 2. The composition of claim 1, wherein the peptide is soluble in an aqueous solution. 3. The composition of claim 2, wherein the peptide is at a therapeutically effective concentration. 4. The composition of claim 1, wherein the peptide is formed by digestion of elastin with thermolysin. 5. The composition of claim 3, wherein the therapeutically effective concentration is a range of about 0.0002% to about 90%. 6. The composition of claim 5, wherein the therapeutically effective concentration is in the range of about 0.5% to about 10%. 7. The composition of claim 1, wherein the composition is a cosmetic preparation. 8. The composition of claim 7, wherein the cosmetic preparation is selected from an emulsion, a lotion, a spray, an aerosol, a powder, an ointment, a cream or a foam. 9. The composition of claim 1, wherein the tissue being treated is a blood vessel. 10. The composition of claim 1, wherein the composition is used for treating a condition selected from hypertension, coronary heart disease, arteriosclerosis, angina, coronary thrombosis, chronic obstructive pulmonary disease, and restenosis post angioplasty. 11. The composition of claim 1, wherein the composition further comprises at least one steroid. 12. A composition useful in improving tissue turgor, said composition being comprised of SEQ ID 12. 13. The composition of claim 12, wherein the composition further includes a pharmaceutical delivery system. 14. The composition of claim 12, wherein the peptide is derived from elastin. 15. The composition of claim 14, wherein the peptide is derived from animal tissue. 16. The composition of claim 13, wherein the pharmaceutical delivery system is a topical delivery system. 17. The composition of claim 16, wherein the pharmaceutical delivery system is a subcutaneous delivery system. 18. The composition of claim 16, wherein the topical delivery system is selected from a cosmetic preparation, a powder, an emulsion, a lotion, a spray, an ointment, an aerosol, a cream or a foam. 19. The composition of claim 12, wherein the composition further comprises at least one steroid. 20. A pharmaceutical composition comprised of SEQ ID 12. 21. The pharmaceutical composition of claim 20, wherein application of the composition to a patient results in neovascularization. 22. The pharmaceutical composition of claim 20, wherein application of the composition to a patient results in angiogenesis. 23. The pharmaceutical composition of claim 20, wherein the composition further comprises at least one steroid. 24. The pharmaceutical composition of claim 20, wherein the composition is formulated as a topical preparation. 25. The pharmaceutical composition of claim 24, wherein the composition is formulated as a preparation selected from a cosmetic preparation, a powder, an emulsion, a lotion, a spray, an ointment, an aerosol, a cream or a foam.
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