Ophthalmic compositions comprising a branched, glycerol monoalkyl compound and a fatty acid monoester
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C11D-003/48
C11D-003/44
출원번호
UP-0691125
(2007-03-26)
등록번호
US-7670997
(2010-04-21)
발명자
/ 주소
Burke, Susan E.
Phillips, Eric
Zhao, Fang
Barniak, Vicki
Salamone, Joseph C.
출원인 / 주소
Bausch & Lomb Incorporated
인용정보
피인용 횟수 :
1인용 특허 :
8
초록▼
An aqueous ophthalmic composition comprising a branched, glycerol monoalkyl compound and a fatty acid monoester. The fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms and an aliphatic hydroxyl portion. The composition will also have an osmolality in a
An aqueous ophthalmic composition comprising a branched, glycerol monoalkyl compound and a fatty acid monoester. The fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms and an aliphatic hydroxyl portion. The composition will also have an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg. The invention is also directed to a method of inhibiting the formation of foam in an aqueous ophthalmic composition that includes a surfactant as well as to a method of enhancing the biocidal efficacy of an aqueous ophthalmic composition containing a fatty acid monoester.
대표청구항▼
We claim: 1. An aqueous ophthalmic composition comprising: a branched, glycerol monoalkyl compound; a fatty acid monoester, wherein the fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms and an aliphatic hydroxyl portion; and a cationic antimicrobial
We claim: 1. An aqueous ophthalmic composition comprising: a branched, glycerol monoalkyl compound; a fatty acid monoester, wherein the fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms and an aliphatic hydroxyl portion; and a cationic antimicrobial component selected from the group consisting of poly[dimethylimino-2-butene-1,4-diyl]chloride, α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride, myristamidopropyl dimethylamine, benzalkonium halides, alexidine and salts thereof, salts of chlorhexidine, hexamethylene biguanides and salts thereof and their polymers, and mixtures thereof, said composition having an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg. 2. The composition of claim 1 wherein the branched, glycerol monoalkyl compound is selected from a branched, glycerol monoalkyl ether, a branched, glycerol monoalkyl amine or a branched, glycerol monoalkyl sulfide, or any mixture thereof. 3. The composition of claim 1 wherein the aliphatic fatty acid portion is a straight chain, saturated or unsaturated hydrocarbon with eight to ten carbons, or a branched chain, saturated or unsaturated hydrocarbon with eight to ten carbons. 4. The composition of claim 1 wherein the aliphatic hydroxyl portion is selected from propylene glycol, polyethylene glycol, polypropylene glycol, glycerol, linear polyol and cyclic polyol. 5. The composition of claim 4 wherein the aliphatic hydroxyl portion is glycerol. 6. The composition of claim 1 wherein the branched, glycerol monoalkyl compound is 3-[(2-ethylhexyl)oxy]-1,2-propanediol, 3-[(2-ethylhexyl)amino]-1,2-propanediol, 3-[(2-ethylhexyl)thiol]-1,2-propanediol or any mixture thereof. 7. The composition of claim 1 wherein the cationic antimicrobial component is selected from the group consisting of poly(hexamethylene biguanide) or PHMB-CG*, which is present from 0.01 ppm to 3 ppm, α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride, which is present from 1 ppm to 100 ppm, and any mixture thereof. 8. The composition of claim 3 further comprising dexpanthenol, sorbitol or any mixture thereof. 9. The composition of claim 3 further comprising 2-amino-2-methyl-1,3-propanediol, and glycolic acid, asparatic acid or a mixture thereof, wherein a molar ratio of the total glycolic acid, asparatic acid or mixture thereof to AMPD is from 1:20 to 1.3:1. 10. The composition of claim 1 formulated in the form of an eye care or a contact lens care product selected from the group consisting of eye drops, contact lens preservative solution, contact lens cleaning solution, and contact lens multi-purpose solution. 11. The composition of claim 1 formulated as a contact lens multi-purpose solution to disinfect a soft contact lens. 12. A method of inhibiting the formation of foam in an aqueous ophthalmic composition comprising a fatty acid monoester, wherein the fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms and an aliphatic hydroxyl portion, the method comprising adding a branched, glycerol monoalkyl compound to the composition in an amount from 0.05 ppm to 30.0 ppm to inhibit the formation of foam or to destabilize foam in the composition, the composition further comprising a cationic antimicrobial component selected from the group consisting of poly[dimethylimino-2-butene-1,4-diyl]chloride, α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride, myristamidopropyl dimethylamine, benzalkonium halides, alexidine and salts thereof, salts of chlorhexidine, hexamethylene biguanides and salts thereof and their polymers, and mixtures thereof, and having an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg. 13. The method of claim 12 wherein the branched, glycerol monoalkyl compound is selected from a branched, glycerol monoalkyl ether, a branched, glycerol monoalkyl amine or a branched, glycerol monoalkyl sulfide, or any mixture thereof. 14. The method of claim 12 wherein the cationic antimicrobial component is selected from the group consisting of poly(hexamethylene biguanide), which is present from 0.01 ppm to 3 ppm, α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride, which is present from 1 ppm to 100 ppm, and any mixture thereof. 15. A method of enhancing the biocidal efficacy of an aqueous ophthalmic composition containing a fatty acid monoester, the method comprising adding a branched, glycerol monoalkyl compound to the composition, and adding one or more cationic antimicrobial components selected from the group consisting of poly[dimethylimino-2-butene-1,4-diyl]chloride, α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride, myristamidopropyl dimethylamine, benzalkonium halides, alexidine and salts thereof, salts of chiorhexidine and hexamethylene biguanides and salts thereof and their polymers, to the composition, wherein the cationic antimicrobial component is added in an effective amount to provide a contact lens multipurpose solution to disinfect soft silicon lenses, wherein the wherein the fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms and an aliphatic hydroxyl portion, and the composition has an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg. 16. The method of claim 15 wherein the one or more cationic antimicrobial components are selected from the group consisting of poly(hexamethylene biguanide) or PHMB-CG*, which is present from 0.01 ppm to 3 ppm, and α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride, which is present from 1 ppm to 100 ppm. 17. The method of claim 15 wherein the branched, glycerol monoalkyl compound is selected from a branched, glycerol monoalkyl ether, a branched, glycerol monoalkyl amine, a branched, glycerol monoalkyl sulfide, or any mixture thereof, and is present in a total amount from 0.05 ppm to 1,000 ppm.
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이 특허에 인용된 특허 (8)
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