Phosphorus-containing compounds with polymeric chains, and methods of making and using the same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C08G-079/02
C08G-079/04
C08G-079/00
출원번호
UP-0355359
(2009-01-16)
등록번호
US-7674875
(2010-04-21)
발명자
/ 주소
Branham, Keith
Chaubal, Mahesh V.
English, James P.
Hall, Donna
Zhao, Zhong
출원인 / 주소
Eisai Inc.
대리인 / 주소
Gordon, Dana M.
인용정보
피인용 횟수 :
1인용 특허 :
34
초록▼
The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, ar
The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
대표청구항▼
We claim: 1. A composition, comprising a phosphorus-containing compound with a star structure represented by the following formula: wherein, independently for each occurrence, r represents 0 or 1, and s represents 3 or 2, such that r+s=3; R1 represents R2 is —O-alkyl; R7 is —O&
We claim: 1. A composition, comprising a phosphorus-containing compound with a star structure represented by the following formula: wherein, independently for each occurrence, r represents 0 or 1, and s represents 3 or 2, such that r+s=3; R1 represents R2 is —O-alkyl; R7 is —O—(CH2)mCH3 or —O—(CH2CH2O)mCH3; m is at least 1; the t1 and t2 units may be in any order; n1:n2 is about 1:1; and the molecular weight of the compound is from about 1,000 to about 10,000 daltons. 2. The composition of claim 1, wherein the molecular weight of the compound is about 1496 or about 2153 daltons. 3. The composition of claim 1, wherein s is 3; R7 is —O—(CH2)mCH3; m is 11; and the molecular weight of the compound is about 2153 daltons. 4. The composition of claim 1, wherein s is 2; R2 is —O—CH2CH3; R7 is —O—(CH2)mCH3; m is 11; and the molecular weight of the compound is about 1496 daltons. 5. A composition, comprising a phosphorus-containing compound with a star structure represented by the following formula: wherein, independently for each occurrence, r represents 0 or 1, and s represents 3 or 2, such that r+s=3; R1 is R2 is —O-alkyl; R7 is —O—(CH2)mCH3 or —O—(CH2CH2O)mCH3; m is at least 1; the t1 and t2 units may be in any order; n1:n2 is about 3:1, about 2:1 about 3:2, or about 1:1, or n2 is 0; and the molecular weight of the compound is from about 1,000 to about 10,000 daltons. 6. The composition of claim 5, wherein the molecular weight of the compound is about 1526, about 1812, about 1912, about 2198, about 2627, about 2800, about 2915, about 3150, about 3994, about 4110, about 4154, about 4634, about 4954, about 6140, or about 7340 daltons. 7. The composition of claim 5, wherein s is 3; R7 is —O—(CH2)mCH3; m is 11; n1:n2 is about 3:2; and the molecular weight of the compound is about 2198 daltons. 8. The composition of claim 5, wherein s is 2; R2 is —O—CH2CH3; R7 is —O—(CH2)mCH3; m is 11; n1:n2 is about 3:2; and the molecular weight of the compound is about 1526 daltons. 9. The composition of claim 5, wherein s is 3; R7 is —O—(CH2CH2O)mCH3; n1:n2 is about 3:2; and the molecular weight of the compound is about 2627 or about 4110 daltons. 10. The composition of claim 5, wherein s is 3; R7 is —O—(CH2CH2O)mCH3; n1:n2 is about 3:1; and the molecular weight of the compound is about 2915, about 4634, about 6140, or about 7340 daltons. 11. The composition of claim 5, wherein s is 2; R2 is —O—CH2CH3; R7 is —O—(CH2CH2O)mCH3; n1:n2 is about 3:2; and the molecular weight of the compound is about 1812 or about 2800 daltons. 12. The composition of claim 5, wherein s is 2; R2 is —O—CH2CH3; R7 is —O—(CH2CH2O)mCH3; n1:n2 is about 3:1; and the molecular weight of the compound is about 1912, about 3150, about 4154, or about 4954 daltons. 13. The composition of claim 5, wherein s is 2; R2 is —O—CH2CH3; R7 is —O—(CH2CH2O)mCH3; n2 is 0; and the molecular weight of the compound is about 3994 daltons. 14. A composition, comprising a phosphorus-containing compound with a star structure represented by the following formula: wherein, independently for each occurrence, r represents 0 or 1, and s represents 3 or 2, such that r+s=3; R1 is R2 is —O-alkyl; R7 is (CH2)mCH3 or —(CH2CH2O)mCH3; m is at least 1; x is at least 2; and the molecular weight of the compound is from about 1,000 to about 10,000 daltons. 15. The composition of claim 14, wherein the molecular weight of the compound is about 1483 or about 2134 daltons. 16. The composition of claim 14, wherein s is 3; R7 is —O—(CH2)mCH3; m is 11; and the molecular weight of the compound is about 2134 daltons. 17. The composition of claim 14, wherein s is 2; R2 is —O—CH2CH3; R7 is —O—CH2)mCH3; m is 11; and the molecular weight of the compound is about 1483 daltons.
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