The present invention describes the identification and purification of 7-hydroxychromes that exhibit potent antioxidant activity. In one embodiment the present invention includes a method for providing an antioxidant to a host in need thereof, comprising administering an effective amount of a 7-hydr
The present invention describes the identification and purification of 7-hydroxychromes that exhibit potent antioxidant activity. In one embodiment the present invention includes a method for providing an antioxidant to a host in need thereof, comprising administering an effective amount of a 7-hydroxychrome or a mixture of 7-hydroxychromones. The present invention includes methods that are effective in inhibiting free radical and oxidation caused damage through the simultaneous suppression of free radical generation and the suppression of the production of reactive oxygen species (ROS). The present invention also includes methods for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes. The method for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes is comprised of administering to a host in need thereof an effective amount of a composition comprised of a 7-hydroxychrome or a mixture of 7-hydroxychromones and a pharmaceutically acceptable carrier. Included in this invention is an improved method to isolate and purify 7-hydroxychromones from plant sources.
대표청구항▼
What is claimed is: 1. A method for treating ROS mediated diseases and conditions comprising administering to a host in need thereof an effective amount of a composition comprised of a plant extract, wherein said plant extract is comprised of a 7-hydroxychrome or a mixture of 7-hydroxychromones whe
What is claimed is: 1. A method for treating ROS mediated diseases and conditions comprising administering to a host in need thereof an effective amount of a composition comprised of a plant extract, wherein said plant extract is comprised of a 7-hydroxychrome or a mixture of 7-hydroxychromones wherein said 7-hydroxychrome(s) are selected from the group of compounds having the following structure: wherein R1, R2 and R3 are independently selected from the group consisting of —H, —OH, SH, alkyl, alkenyl, oxoalkyl, oxoalkenyl, hydroxylalkyl, hydroxylalkenyl, —OR, SR, NH2, —NRH, —NR2, —NR3+X−, an ester selected from the group consisting of gallate, acetate, cinnamoyl and hydroxyl-cinnamoyl esters, trihydroxybenzoyl esters and caffeoyl esters and a glycoside, a thioglycoside, a nitrogen glycoside, or a carbon glycoside, wherein said glycoside is linked to the 7-hydroxychromone by a carbon or oxygen of a single or a combination of multiple sugars selected from the group consisting of aldopentoses, methyl aldopentose, aldohexoses and ketohexoses and wherein said glycoside is optionally substituted to form an ester selected from the group consisting of gallate, acetate, cinnamoyl and hydroxyl-cinnamoyl esters, trihydroxybenzoyl esters and caffeoyl esters; wherein said alkyl and/or alkenyl group is a straight and/or branched chain having between 1-20 carbon atoms with and/or without double bonds in different positions; X is selected from the group of pharmaceutically acceptable counter anions consisting of hydroxyl, chloride, iodide, sulfate, phosphate, acetate, fluoride, and carbonate; R is an alkyl group having between 1-20 carbon atoms and a pharmaceutically acceptable carrier; and wherein the composition is comprised of 1% to 100 of the 7-hydroxychromone. 2. The method of claim 1 wherein said 7-hydroxychrome is selected from aloesin or aloeresin A. 3. The method of claim 1 wherein said plant is selected from the group consisting of the genus of Acacia, Adina, Aloe, Alternaria, Amoora, Antidesma, Artemisia, Baeckia, Cassia, Clusea, Cnidium, Convolvulus, Epimedium, Eriosema, Eriostemon, Eugenia, Garcinia, Hypericum, Lindenbergia, Pancratium, Penicillium, Polygonum, Ptaeroxylon, Rheum, Sophora, Stephanitis, Syzygium, Talaromyces and Zonaria. 4. The method of claim 3 wherein said plant is selected from the group consisting of Acacia catechu, Acacia concinna, Aloearborescens, Aloe barbadensis, Aloe cremnophila, Aloe ferox, Aloe saponaria, Aloe vera,Aloe vera var. chinensis, Antidesmamembranaceum, Artemisia capillaries, Baeckiafrutescens, Epimedium sagittatum, Garcinia dulcis, Hypericumjaponicum, Polygonum Cuspidatum, Sophora tomentosa, and Stephanitis rhododendri. 5. The method of claim 1 wherein said plant extract is obtained from a plant part selected from the group consisting of stems, stem barks, trunks, trunk barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers and other reproductive organs, leaves and other aerial parts. 6. The method of claim 1 wherein the ROS mediated diseases and conditions are selected from the group consisting of atherosclerosis, coronary heart diseases, cataracts, dementia, Alzheimer's disease, cognitive dysfunction, diabetes mellitus, cancer, skin photo aging, skin wrinkles, sun burns, melanoma, and other degenerative processes associated with aging. 7. The method of claim 1 wherein the composition is administered in a dosage selected from 0.01 to 200 mg/kg of body weight. 8. The method of claim 1 wherein the routes of the administration are selected from the group consisting of oral, topical, suppository, intravenous, and intradermic, intragaster, intramusclar, intraperitoneal and intravenous administration in an appropriate pharmaceutical formula. 9. The method of claim 1 wherein the composition is administered in a dosage selected from 50 mg to 250 mg of 7-hydroxychromone(s) per dose. 10. The method of claim 4 wherein said plant is Aloe ferox.
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