Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/352
C07D-311/30
출원번호
UP-0854063
(2004-05-26)
등록번호
US-7683095
(2010-04-21)
발명자
/ 주소
Guthrie, Najla
Kurowska, Elzbieta Maria
Manthey, John A.
출원인 / 주소
The United States of America as represented by the Secretary of Agriculture
KGK Synergize, Inc.
대리인 / 주소
Lowenstein Sandler PC
인용정보
피인용 횟수 :
2인용 특허 :
6
초록▼
Compositions and methods for the treatment, reduction and/or prevention of cardiovascular diseases and disorders are described. Individuals at high risk for developing or having cardiovascular disease or disorder may be treated with an effective dose of a polymethoxyflavone including limocitrin deri
Compositions and methods for the treatment, reduction and/or prevention of cardiovascular diseases and disorders are described. Individuals at high risk for developing or having cardiovascular disease or disorder may be treated with an effective dose of a polymethoxyflavone including limocitrin derivatives, quercetin derivatives, naturally occurring polymethoxyflavones, tocotrienols, and mixtures of these compounds.
대표청구항▼
We claim: 1. A method of lowering serum cholesterol, Apo B or LDL cholesterol comprising orally administering to a mammal having elevated levels of serum cholesterol, Apo B or LDL cholesterol an oral pharmaceutical dosage form selected from the group consisting of a tablet or a capsule, said dosage
We claim: 1. A method of lowering serum cholesterol, Apo B or LDL cholesterol comprising orally administering to a mammal having elevated levels of serum cholesterol, Apo B or LDL cholesterol an oral pharmaceutical dosage form selected from the group consisting of a tablet or a capsule, said dosage form comprising at least one pharmaceutically acceptable excipient and a combination of (a) at least one limocitrin derivative selected from the group consisting of limocitrin-3,7,4′-trimethylether; limocitrin-3,5,7,4′-tetramethylether; and limocitrin-3,7,4′-trimethylether-5-acetate, and (b) at least one quercetin derivative selected from the group consisting of quercetin tetramethylether; quercetin 3,5-dimethylether-7,3′,4′-tribenzylether; quercetin pentamethylether; quercetin-5,7,3′,4′-tetramethylether-3-acetate; and quercetin-5,7,3′,4′-tetramethylether; to provide about 1-1000 mg/day limocitrin derivative and about 1-1000 mg/day quercetin derivative. 2. The method of claim 1, wherein the dosage form further comprises at least one tocotrienol and wherein the administration provides an amount of said dosage form to provide about 1-1000 mg/day tocotrienol. 3. The method of claim 1, wherein the tablet or capsule contains a predetermined amount of the mixture as solids, gelatins, suspensions or emulsions. 4. The method of claim 1, wherein the pharmaceutical acceptable excipient is a gel phase carrier. 5. The method of claim 1, wherein the pharmaceutically acceptable excipient is selected from the group consisting of calcium carbonate, calcium phosphate, a sugar, a starch, a cellulose derivative, gelatin and a polymer. 6. The method of claim 1, wherein the dosage form further comprises at least one polymethoxyflavone and wherein the administration provides an amount of said dosage form to provide about 1-1000 mg/day polymethoxyflavone. 7. The method of claim 1, wherein said mammal is a human.
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이 특허에 인용된 특허 (6)
Guthrie Najla,CAX ; Kurowska Elzbieta Maria,CAX, Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols.
Guthrie,Najla; Kurowska,Elzbieta Maria; Manthey,John A.; Horowitz,Sylvia; Horowitz,Robert M., Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones.
Guthrie Najla,CAX ; Kurowska Elzbieta Maria,CAX ; Carroll Kenneth Kitchener,CAX, Compositions and methods of treatment of neoplastic diseases and hypercholesterolemia with citrus limonoids and flavonoids and tocotrienols.
Lane Ronald H. (Phoenix AZ) Qureshi Asaf A. (Madison WI) Salser Winston A. (Pacific Palisades CA), Tocotrienols and tocotrienol-like compounds and methods for their use.
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