초록 ▼

An implantable medical device, such as a stent, is disclosed. The device includes a substrate and a polymeric layer including poly(methylmethacrylate) or poly(butylmethacrylate) supported by the substrate. The polymeric layer contains rapamycin. A barrier is over at least a portion of the polymeric

An implantable medical device, such as a stent, is disclosed. The device includes a substrate and a polymeric layer including poly(methylmethacrylate) or poly(butylmethacrylate) supported by the substrate. The polymeric layer contains rapamycin. A barrier is over at least a portion of the polymeric layer to reduce the rate of release of rapamycin from the implantable medical device. The polymeric layer can additionally include poly(ethylene co-vinyl acetate).

대표청구항 ▼

What is claimed is: 1. An implantable medical device, comprising: a substrate adapted to be implanted at a site in need of therapy; a polymeric layer comprising poly(methylmethacrylate) or poly(butylmethacrylate) supported by the substrate, the polymeric layer containing rapamycin for administering

What is claimed is: 1. An implantable medical device, comprising: a substrate adapted to be implanted at a site in need of therapy; a polymeric layer comprising poly(methylmethacrylate) or poly(butylmethacrylate) supported by the substrate, the polymeric layer containing rapamycin for administering rapamycin to the site in need of therapy by diffusing through the polymeric layer to the site; and a barrier over at least a portion of the polymeric layer to reduce the rate of release of rapamycin from the implantable medical device. 2. The implantable medical device of claim 1, wherein the barrier degrades. 3. The implantable medical device of claim 1, wherein the polymeric layer additionally includes poly(ethylene co-vinyl acetate). 4. The implantable medical device of claim 1, wherein the device is a stent. 5. A method of making an implantable medical device, the method comprising: forming a coating on the device, wherein the coating comprises poly(butyl methacrylate), rapamycin and poly(ethylene co-vinyl acetate); and forming a barrier layer for reducing a rate of release of rapamycin after implantation of the device into a body of a patient. 6. The method of claim 5, wherein the coating is formed by applying a plurality of layers of poly(butyl methacrylate), rapamycin and poly(ethylene co-vinyl acetate) to the device. 7. The method of claim 5, wherein the device is a stent. 8. The implantable medical device of claim 1, wherein the barrier comprises a polymer. 9. The implantable medical device of claim 1, wherein the barrier comprises an inorganic material. 10. The implantable medical device of claim 3, wherein the barrier comprises a polymer and wherein the polymeric layer includes poly(butylmethacrylate). 11. The implantable medical device of claim 10, wherein the device is a stent. 12. The implantable medical device of claim 10, wherein the barrier is a homogeneous layer. 13. The implantable medical device of claim 1, wherein the barrier comprises a polymer; wherein the polymeric layer consists of poly(butylmethacrylate), poly(ethylene co-vinyl acetate), and rapamycin; and wherein the device is a stent. 14. The implantable medical device of claim 1, wherein the barrier comprises a metallic material. 15. The method of claim 5, wherein the barrier layer comprises a polymer. 16. The method of claim 5, wherein the barrier layer comprises a polymer and the device is a stent. 17. The method of claim 16, wherein the barrier layer is blended into the coating. 18. The method of claim 5, wherein the barrier layer comprises an inorganic material.