IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
UP-0391133
(2006-03-28)
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등록번호 |
US-7697968
(2010-05-20)
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발명자
/ 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
9 인용 특허 :
10 |
초록
▼
A method, computer-readable medium, and system for predicting a response to tongue-base therapies (particularly as it relates to obstructive sleep apnea) are provided. The method includes generating with a processing element a plurality of images of at least a portion of a patient's anatomy, acquiri
A method, computer-readable medium, and system for predicting a response to tongue-base therapies (particularly as it relates to obstructive sleep apnea) are provided. The method includes generating with a processing element a plurality of images of at least a portion of a patient's anatomy, acquiring data indicative of the portion of the patient's anatomy from the images, and determining a probability of a patient's response to a tongue-base treatment based on the acquired data.
대표청구항
▼
That which is claimed: 1. A storage method in the form of a memory device for predicting a response to tongue-base therapies comprising: generating a plurality of images of an axial view of a patient's upper airway, wherein each image depicts a cross-sectional plane of the patient's upper airway, t
That which is claimed: 1. A storage method in the form of a memory device for predicting a response to tongue-base therapies comprising: generating a plurality of images of an axial view of a patient's upper airway, wherein each image depicts a cross-sectional plane of the patient's upper airway, the cross-sectional plane extending substantially transverse to a longitudinal axis of the patient's pharynx; acquiring data indicative of the patient's upper airway from the images, wherein the data comprises at least an anterior/posterior measurement and a lateral measurement both determined from the images of the axial view of the patient's upper airway; and determining a probability of a patient's response to a tongue-base treatment based on the acquired data and patient-specific physiological data, wherein the probability is determined by comparing the acquired data and the patient-specific physiological data for the patient to an expected relationship between similar acquired data and patient-specific physiological data. 2. The method according to claim 1, wherein the patient-specific physiological data comprises at least one of body mass index, respiratory disturbance index or apnea hypopnea index, age, neck circumference, or gender. 3. The method according to claim 1, wherein generating comprises generating a plurality of images during a wakefulness state or a sleep state. 4. The method according to claim 1, wherein acquiring comprises acquiring a third measurement of the upper airway such that the anterior/posterior measurement, lateral measurement, and the third measurement provide information regarding a volumetric change of the patient's upper airway. 5. The method of claim 1, wherein determining comprises calculating a statistical probability of a patient's response to a tongue-base treatment using a multivariate algorithm. 6. The method of claim 1, wherein generating comprises generating a plurality of images of an axial view of a patient's upper airway in a retroepiglottic region, and wherein acquiring comprises acquiring an anterior/posterior measurement and a lateral measurement both taken from the axial view of the patient's upper airway in the retroepiglottic region. 7. The method of claim 1, further comprising determining an expected relationship between similar acquired data and patient-specific physiological data obtained from a plurality of patients. 8. The method according to claim I, further comprising displaying the expected relationship as a graphical image, wherein determining the probability comprises determining a location of the acquired data and the patient-specific physiological data for the patient on the graphical image. 9. The method of claim 8, wherein displaying comprises displaying the expected relationship as a graphical image in three-dimensional space. 10. The method according to claim 1, wherein determining comprises determining the probability of a response to treatment for obstructive sleep apnea. 11. The method according to claim 10, wherein determining comprises determining the probability of response to at least one of a treatment of obstructive sleep apnea with oral appliances, tongue-base directed therapies, or mandibular advancement surgery. 12. The method according to claim 1, further comprising capturing data indicative of at least a portion of a patient's upper airway. 13. The method according to claim 12, wherein generating comprises generating the at least one image based on the captured data. 14. The method of claim 1, wherein the anterior/posterior measurement comprises a measurement between the patient's posterior pharyngeal wall and epiglottis tip. 15. The method of claim 14, wherein the lateral measurement comprises a lateral measurement between the pharyngeal wall that is substantially transverse to the anterior-posterior measurement. 16. The method according to claim 1, wherein generating comprises generating at least one supine hypotonic image of an upper airway of the patient with the patient's head and neck in a neutral standard position. 17. The method according to claim 16, wherein generating comprises generating at least one image of an airway with the mandible at rest and the mandible at an advanced position. 18. The method according to claim 17, wherein acquiring comprises acquiring an anterior/posterior measurement and a lateral measurement of a most critical site of proximal narrowing of the upper airway with the mandible at rest and the mandible at an advanced position. 19. The method according to claim 17, wherein acquiring comprises acquiring at least one of an area of a most critical site of proximal narrowing of the upper airway with the mandible at rest or the mandible at an advanced position. 20. The method according to claim 19, wherein acquiring comprises acquiring a percentage area airway expansion. 21. A computer-readable medium containing instructions for causing a processing element to perform the steps of: generating a plurality of images of an axial view of a patient's upper airway, wherein each image depicts a cross-sectional plane of the patient's upper airway, the cross-sectional plane extending substantially transverse to a longitudinal axis of the patient's pharynx; acquiring data indicative of the patient's upper airway from the images, wherein the data comprises at least an anterior/posterior measurement and a lateral measurement both determined from the images of the axial view of the patient's upper airway; and determining a probability of a patient's response to a tongue-base treatment based on the acquired data and patient-specific physiological data, wherein the probability is determined by comparing the acquired data and the patient-specific physiological data for the patient to an expected relationship between similar acquired data and patient-specific physiological data. 22. The computer-readable medium according to claim 21, wherein the patient-specific physiological data comprises at least one of body mass index, respiratory disturbance index or apnea hypopnea index, age, neck circumference, or gender. 23. The computer-readable medium according to claim 21, further comprising displaying the expected relationship as a graphical images, wherein determining the probability comprises determining a location of the acquired data and the patient-specific physiological data for the patient on the graphical image. 24. The computer-readable medium of claim 21, further comprising determining an expected relationship between similar acquired data and patient-specific physiological data obtained from a plurality of patients. 25. The computer-readable medium according to claim 21, wherein determining comprises determining the probability of a response to treatment for obstructive sleep apnea. 26. The computer-readable medium according to claim 25, wherein determining comprises determining the probability of response to at least one of a treatment of obstructive sleep apnea with oral appliances, tongue-base directed therapies, or mandibular advancement surgery. 27. The computer-readable medium according to claim 21, further comprising capturing data indicative of at least a portion of a patient's upper airway. 28. The computer-readable medium according to claim 27, wherein generating comprises generating the at least one image based on the captured data. 29. The computer-readable medium according to claim 21, wherein generating comprises generating at least one supine hypotonic image of an upper airway of the patient with the patient's head and neck in a neutral standard position. 30. The computer-readable medium according to claim 29, wherein generating comprises generating at least one image of an airway with the mandible at rest and the mandible at an advanced position. 31. The computer-readable medium according to claim 30, wherein acquiring comprises acquiring an anterior/posterior measurement and a lateral measurement of a most critical site of proximal narrowing of the upper airway with the mandible at rest and the mandible at an advanced position. 32. The computer-readable medium according to claim 30, wherein acquiring comprises acquiring at least one of an area of a most critical site of proximal narrowing of the upper airway with the mandible at rest or the mandible at an advanced position. 33. The computer-readable medium according to claim 32, wherein acquiring comprises acquiring a percentage area airway expansion. 34. A system for predicting a response to tongue-base therapies comprising: a device for capturing data indicative of an axial view of a patient's upper airway; and a processing element in communication with the device and for generating a plurality of images based on the captured data, wherein each image depicts a cross-sectional plane of the patient's upper airway, the cross-sectional plane extending substantially transverse to a longitudinal axis of the patient's pharynx, acquiring data indicative of the patient's upper airway from the images, wherein the data comprises at least an anterior/posterior measurement and a lateral measurement both determined from the images of the axial view of the patient's upper airway, and determining a probability of a patient's response to a tongue-base treatment based on the acquired data and patient-specific physiological data, wherein the probability is determined by comparing the acquired data and the patient-specific physiological data for the patient to an expected relationship between similar acquired data and patient-specific physiological data. 35. The system of claim 34, wherein the processing element is configured to determine an expected relationship between similar acquired data and patient-specific physiological data obtained from a plurality of patients. 36. The system according to claim 34, wherein the device comprises one of an endoscope, acoustic pharyngometer, ultrasound, MRI, or CT scanner. 37. The system according to claim 36, wherein the processing element comprises a graphical user interface for displaying the plurality of images. 38. The system according to claim 37, wherein the graphical user interface is capable of displaying an image representative of the expected relationship, wherein the processing element is configured to determine the probability by locating the acquired data and the patient-specific physiological data for the patient on the image. 39. A method for predicting a response to tongue-base therapies comprising: generating a plurality of images of an axial view of a patient's upper airway in a retroepiglottic region, wherein each image depicts a cross-sectional plane of the patient's upper airway, the cross-sectional plane extending substantially transverse to a longitudinal axis of the patient's pharynx; acquiring data indicative of the patient's upper airway from the images, wherein the data comprises at least an anterior/posterior measurement and a lateral measurement both determined from the images of the axial view of the patient's upper airway in the retroepiglottic region; determining an expected relationship between similar acquired data and patient-specific physiological data obtained from a plurality of patients; and determining a probability of a patient's response to a tongue-base treatment based on a comparison of the acquired data and patient-specific physiological data for the patient to the expected relationship. 40. The method according to claim 39, further comprising displaying the expected relationship as a graphical image, wherein determining the probability comprises determining a location of the acquired data and the patient-specific physiological data for the patient on the graphical image.
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