초록 ▼

The invention provides a system for respiratory pharmacology test and a chamber device that enables respiratory pharmacology test on particular large animals under unanesthetized, unrestrained state, with easy acclimatization and reduced effect of stress, and a method for conducting safety pharmacol

The invention provides a system for respiratory pharmacology test and a chamber device that enables respiratory pharmacology test on particular large animals under unanesthetized, unrestrained state, with easy acclimatization and reduced effect of stress, and a method for conducting safety pharmacology studies on the same large animal individual. The chamber device of the invention includes animal cage 10 and transparent chamber 20, which includes first and second compartments 21 and 22 separated by partition plate 23. The compartment 21 has a door and ventilation connection port 26, and the compartments 21 and 22 are provided with communication pipe 29 having opening 29a for introducing ambient air. The device of the invention has ventilation connection port 26 in a side face of the chamber 20, and communication pipe 29 for introducing air on the top face of the chamber 20, so that, with the cage 10 placed in the compartment 21, air flow through the compartment 21 is maintained constantly and allowed to communicate through the cage 10.

대표청구항 ▼

What is claimed is: 1. A system for respiratory pharmacology test comprising: a chamber device for housing an animal selected from monkeys, dogs, or pigs, for conducting respiratory pharmacology test under unanaesthetized, unrestrained state, said chamber device comprising: an animal cage securing

What is claimed is: 1. A system for respiratory pharmacology test comprising: a chamber device for housing an animal selected from monkeys, dogs, or pigs, for conducting respiratory pharmacology test under unanaesthetized, unrestrained state, said chamber device comprising: an animal cage securing a living space for said animal, said cage having at least front and top faces made of metal grids for allowing inside observation and ventilation, and a grid door in the front face for entrance and exit of said animal, and a transparent chamber, wherein said chamber comprises: a partition plate for partitioning interior of said chamber into a first compartment for accommodating said cage and a second compartment for compensating for an effect of atmospheric pressure variations on results of the respiratory test, a door for allowing said cage to be placed in and removed from said first compartment, a ventilation connection port for connecting ventilation means for ventilating said first compartment, a communication pipe having at least three openings, said communication pipe allowing introduction of ambient air into said first compartment and communication between said first and second compartments, wherein said ventilation connection port is arranged at a position in a side face of said chamber and said communication pipe is disposed at a position on a top face of said chamber so that, with said cage placed in said first compartment without an animal therein, air flow through said first compartment is maintained constantly and allowed to communicate through said cage placed in said first compartment; in which a measuring instrument for respiratory test is fixed at a desired position, and ventilation means is connected to said ventilation connection port, and a transducer for detecting respiratory-waveform signals installed outside said chamber, wherein said transducer measures inner pressure in the first and second compartments, and transmits data to said measuring instrument after compensating for an effect of atmospheric pressure variations in the first compartment on results of respiratory test with inner pressure variations in the second compartment. 2. The system for respiratory pharmacology test according to claim 1, wherein said cage has caster wheels for facilitating transfer thereof, and wherein said chamber is provided with a cushioning member on the bottom of said first compartment for fixing the caster wheels and buffering shaking of the cage, when the cage is in the first compartment. 3. The system for respiratory pharmacology test according to claim 1, wherein said chamber has, in the first compartment, an insertion aperture for a water supply tube for supplying drinking water to the animal. 4. The system for respiratory pharmacology test according to claim 1, wherein said animal cage is covered with metal walls on faces other than the front and top faces for blocking view and air flow, wherein said ventilation connection port is arranged in a side face of the chamber, at a position above half the height of the side face, closer to the front face of the chamber, and wherein said communication pipe is disposed on the top face of the chamber, crossing over the partition plate, so as to connect the first and second compartments. 5. A method of conducting safety pharmacology studies comprising the steps of: (A) providing the system according to claim 1, (B) acclimatizing an animal selected from monkeys, dogs, or pigs, in the animal cage accommodated in the first compartment of the chamber, (C) administering to the acclimatized animal a test substance for safety pharmacology studies, (D) conducting respiratory test on the animal in the cage administered with the test substance, in unanesthetized, unrestrained state, with the door of the chamber closed, and (E) conducting at least central nervous and cardiovascular tests for safety pharmacology studies of the test substance on the same individual animal as used in the respiratory test.