초록 ▼

The invention provides optimized methods and compositions for enhancing the immune response caused by immunostimulatory compounds used for the treatment of disease such as, but not limited to, treatment of cancer, autoimmune disorders, asthma, respiratory allergies, food allergies and infectious dis

The invention provides optimized methods and compositions for enhancing the immune response caused by immunostimulatory compounds used for the treatment of disease such as, but not limited to, treatment of cancer, autoimmune disorders, asthma, respiratory allergies, food allergies and infectious diseases in a patient. The optimized methods according to the invention provide synergy between the therapeutic effects of immunostimulatory oligonucleotides and immunomer compounds in accordance with the invention, and the therapeutic effect of cytokine immunotherapy and/or chemotherapeutic agents and/or radiation.

대표청구항 ▼

What is claimed is: 1. An immunostimulatory oligonucleotide having the structure 5′-TCTCTTG-X-GTTCTCT-5′; wherein X is a glycerol linker and  is 2′-deoxy-7-deazaguanosine. 2. A pharmaceutical formulation comprising the oligonucleotide according to claim 1 and a physiol

What is claimed is: 1. An immunostimulatory oligonucleotide having the structure 5′-TCTCTTG-X-GTTCTCT-5′; wherein X is a glycerol linker and  is 2′-deoxy-7-deazaguanosine. 2. A pharmaceutical formulation comprising the oligonucleotide according to claim 1 and a physiologically acceptable carrier. 3. A method for generating an immune response in a vertebrate, the method comprising administering to the vertebrate an immunostimulatory oligonucleotide having the structure 5′-TCTCTTG-X-GTTCTCT-5; wherein X is a glycerol linker and  is 2′-deoxy-7-deazaguanosine. 4. The method according to claim 3, wherein the route of administration is selected from parenteral, oral, sublingual, transdermal, topical, intranasal, aerosol, intraocular, intratracheal, intrarectal, vaginal, gene gun, dermal patch, eye drop and mouthwash. 5. The oligonucleotide according to claim 1, further comprising an antibody, antisense oligonucleotide, protein, antigen, allergen, chemotherapeutic agent or adjuvant. 6. The pharmaceutical composition according to claim 2, further comprising an antibody, antisense oligonucleotide, protein, antigen, allergen, chemotherapeutic agent or adjuvant. 7. The method according to claim 3, further comprising administering an antibody, antisense oligonucleotide, protein, antigen, allergen, chemotherapeutic agent or adjuvant.