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Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo. Suitable medical devices include catheters, stents, artificial joints, and the like. NIMELS methods, systems,

Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo. Suitable medical devices include catheters, stents, artificial joints, and the like. NIMELS methods, systems, and apparatus can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant associated with traditional approaches described in the art (e.g., loss of viability, or thermolysis). Lasers including diode lasers may be used for one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. Exemplary embodiments utilize light in a range of 850 nm-900 nm and/or 905 nm-945 nm at suitable NIMELS dosimetries.

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What is claimed is: 1. A therapeutic system for effecting photodamage in a biological contaminant in an illuminated target region of a subject, the system comprising: an optical radiation generation device configured and arranged to generate near infrared optical radiation (i) substantially in a fi

What is claimed is: 1. A therapeutic system for effecting photodamage in a biological contaminant in an illuminated target region of a subject, the system comprising: an optical radiation generation device configured and arranged to generate near infrared optical radiation (i) substantially in a first wavelength range from 865 nm to 875 nm and a second wavelength range having a wavelength from 925 nm to 935 nm, and (ii) at a dosimetry including power density of about 0.5 W/cm2 to about 5 W/cm2 and an energy density from about 200 J/cm2 to about 700 J/cm2 at the illuminated target region, and a time duration of about 50 to about 720 seconds, wherein the dosimetry is sufficient to produce photodamage in the biological contaminant; a delivery assembly for causing the optical radiation to be transmitted to illuminate the target region of the subject, wherein substantially all of the near infrared optical radiation transmitted from the optical radiation generation device to the target region by the delivery assembly is in the first wavelength range or the second wavelength range, and wherein the near infrared optical radiation has a spot size at the target region of at least 1.0 cm; and a controller operatively connected to the optical radiation generation device for controlling dosage of the near infrared optical radiation transmitted to the target region of the subject at the dosimetry sufficient to produce photodamage in the biological contaminant. 2. A therapeutic system according to claim 1, wherein the optical radiation source includes a diode laser. 3. A therapeutic system according to claim 1, wherein the controller is configured and arranged to control the radiation to be an output of a succession of radiation pulses or a continuous wave. 4. A therapeutic system according to claim 1, wherein the controller comprises a dosimetry calculator that is preprogrammed to calculate dosimetry needed for treatment of the treatment site. 5. The therapeutic system of claim 1, wherein the optical radiation transmitted to the target region has a substantially flat-top intensity distribution. 6. The therapeutic system of claim 1, wherein the controller is configured and arranged to provide to the target region a dosimetry comprising a power density from about 1 W/cm2 to about 4 W/cm2 for treatment of onychomycosis. 7. The therapeutic system of claim 6, wherein the delivery assembly is configured and arranged to deliver the optical radiation to a plurality of target regions, wherein treatment can be effected simultaneously on toes of a patient with onychomycosis. 8. The therapeutic system of claim 1, wherein optical radiation has a spot size diameter at the target region of between about 1.0 cm and about 4.0 cm. 9. The therapeutic system of claim 1, wherein the controller is configured and arranged to provide to the target region a dosimetry comprising a power density of about 0.5 W/cm2 to about 2.5 W/cm and an irradiation time of about 50 seconds to about 500 seconds for treatment of bacteria. 10. The therapeutic system of claim 1, wherein the controller is configured and arranged to provide to the target region a dosimetry comprising a power density of about 0.5 W/cm2 to about 3.5 W/cm2 and an irradiation time of about 60 to about 600 seconds for treatment of MRSA. 11. The therapeutic system of claim 1, wherein the controller is configured and arranged to provide to the target region a dosimetry comprising a power density of about 0.5 W/cm2 to about 3.5 W/cm2 and an irradiation time of about 70 to about 700 seconds for treatment of fungi. 12. The system of claim 1, wherein the delivery assembly comprises a flat top lens configured and arranged to receive the optical radiation from the optical radiation generation device and to produce an optical output with a substantially flat-top intensity distribution. 13. A therapeutic treatment system for effecting photodamage in a biological contaminant in an illuminated target region of a subject without use of photosensitizer, the system comprising: an optical radiation generation device configured and arranged to generate optical radiation (i) substantially in a first wavelength range from 865 nm to 875 nm and a second wavelength range having a wavelength from 925 nm to 935 nm, and (ii) at a dosimetry including power density of about 0.5 W/cm2 to about 5 W/cm2 and an energy density from about 200 J/cm2 to about 700 J/cm2 at the illuminated target region, and a time duration of about 50 to about 720 seconds, that is sufficient to produce photodamage in the biological contaminant without a photosensitizer; and a delivery assembly for causing the near infrared optical radiation to be transmitted to the target region, wherein the delivery assembly is configured and arranged to receive the near infrared optical radiation from the optical radiation generation device and to provide the optical radiation to the illuminated target region, wherein substantially all of the near infrared optical radiation transmitted from the optical radiation generation device to the target region by the delivery assembly is in the first wavelength range or the second wavelength range, wherein the near infrared optical radiation has a spot size at the target region of at least 1.0 cm, and wherein the optical intensity is effective for producing photodamage in a biological contaminant at the target region. 14. The system of claim 13, further comprising a controller operatively connected to the optical radiation generation device for controlling dosage of the radiation transmitted to the target region at the dosimetry sufficient to produce photodamage in the biological contaminant without causing substantial photothermal or photomechanical damage to biological tissue of the subject at the illuminated target region. 15. The system of claim 13, wherein the optical radiation generation device comprises one or more diode lasers. 16. The system of claim 13, wherein the delivery assembly is configured and arranged to simultaneously deliver the optical radiation to a plurality of target regions, wherein at each target region the optical radiation has a dosimetry sufficient to produce photodamage in the biological contaminant without intolerable adverse effects on biological tissue at the target region. 17. The system of claim 13, wherein the dosimetry includes power density of about 0.5 W/cm2 to about 40 W/cm2 and a time duration of about 50 to about 720 seconds. 18. The system of claim 14, wherein the controller is configured and arranged to provide to the target region a dosimetry comprising a power density of about 0.5 W/cm2 to about 2.5 W/cm2 and an irradiation time of about 50 seconds to about 500 seconds for treatment of bacteria. 19. The system of claim 14, wherein the controller is configured and arranged to provide to the target region a dosimetry comprising a power density of about 0.5 W/cm2 to about 3.5 W/cm2 and an irradiation time of about 70 to about 700 seconds for treatment of fungi. 20. The therapeutic system of claim 14, wherein the controller is configured and arranged to provide to the target region a dosimetry comprising a power density of about 0.5 W/cm2 to about 3.5 W/cm2 and an irradiation time of about 60 to about 600 seconds for treatment of MRSA.