초록

Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of disorders such as Alzheimer's Disease.

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What is claimed is: 1. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein R30 is selected from the group consisting of pyrazolopyrimidinyl, isoxazolyl, triazolopyridinyl, pyridyl, furyl, naphthothienyl, thiadiazolyl, oxazolidinyl, pyrazinyl mono N-oxide, benzofuran

What is claimed is: 1. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein R30 is selected from the group consisting of pyrazolopyrimidinyl, isoxazolyl, triazolopyridinyl, pyridyl, furyl, naphthothienyl, thiadiazolyl, oxazolidinyl, pyrazinyl mono N-oxide, benzofuranyl, pyrazolyl, benzimidazolyl, indolyl, isoquinolinyl, -thienyl-thienyl, benzothienyl, quinolinyl, thieno[2,3-b]thiophene, benzoxazole benzo[b]thiophene 1,1-dioxideisoindolyl, purinyl, oxazolyl, thiazolyl, pyridazinonyl, benzoindazolyl, imidazopyrazolyl, pyridyl N-oxide, pyrazolopyridinyl, thienopyrazolyl, indazolyl, thienopyridinyl, triazolopyrimidinyl, thienyl, benzooxadiazolyl, carbazolyl, chromeno[3,4-d]isoxazolyl, triazolopyridazinyl, -pyrrolyl-(C1-C6 alkyl)-pyridyl, -pyrrolyl-cyclohexyl, benzooxadiazolyl mono N-oxide, thienoindolyl, thioxobenzothiazolyl,-imidazole-benzyl, thienoquinolinyl, pyrrolopyridinyl, 1-H-imidazo[1,2-b]pyrazolyl, and imidazobenzoxazinyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of C1-C10 alkyl optionally substituted with 1 phenyl or 1 CN; OH, hydroxy C1-C10 alkyl optionally substituted with phenyl or (C1-C4 alkyl)phenyl, C1-C6 alkoxy optionally substituted with 1 or 2 groups that are independently hydroxy or phenyl; haloalkyl, haloalkoxy, (CH2)0-4C(O)NR31R32, —NR31—SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 groups that are independently halogen or R33, —SO2—NH(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, alkoxy, or R33; —(C1-C6 alkyl)-SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, C1-C4 alkoxy, or R33; —SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently OH or C1-C4 alkoxy, —SO2—N(C1-C6 alkyl)(C1-C6 alkyl) wherein each alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH or R33; —SO2—NH(C1-C6 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 groups that are independently C1-C4 alkoxy or halogen, —(C1-C6alkyl)-O-phenyl, —(C1-C6 alkyl)-O—(C1-C6 alkyl)-phenyl, triazolidine-3,5-dione, halogen, —NHC(O)NH2, —NHC(O)NH(C1-C6 alkyl), —NHC(O)N(C1-C6alkyl)(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)NH2, —N(C1-C6 alkyl)C(O)NH(C1-C6alkyl), —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)thienyl, —(C1-C6 alkyl)furanyl, —S—(C1-C6 alkyl)phenyl, —SO2NR31R32, —C(O)—NR31R32, —NR31R32, dithiane, —NHC(S)NH2, —NHC(S)NH(C1-C6 alkyl), —NHC(S)N(C1-C6alkyl)(C1-C6 alkyl), —CO2(C1-C6 alkyl), tetrahydropyran, phenyl optionally substituted with 1 or 2 groups that are independently F, Cl or Br; pyridine, —C2-C4 alkynyl-phenyl, —O—C3-C8 cycloalkyl, —O—(C1-C6 alkyl)-R33; pyrrole optionally substituted with one or two methyl groups; 2,3-dihydro-benzofuran; benzo[1,2,5]oxadiazole, —C(O)—(C1-C10 alkyl) wherein the alkyl group is optionally substituted with NH2, N(C1-C6 alkyl), or N(C1-C6 alkyl)(C1-C6 alkyl); —C(O)NH-phenyl, —C(O)N(C1-C6 alkyl)-phenyl, 4,4-dimethyl-4,5-dihydro-oxazole, —(C1-C6 alkyl)-S-pyridine, —(C1-C6 alkyl)-SO2-pyridine, —(C1-C6 thioalkoxy)-pyridine, thiazole optionally substituted with 1 or 2 methyl groups, pyrazole, —S—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently CN or OH; indole, (C1-C6 thioalkoxy)-(C1-C6 alkyl), C2-C8 alkynyl, —(CH2)0-4—SO2—(C1-C10 alkyl) wherein the alkyl group is optionally substituted with OH; —NHC(O)NH(C3-C8 cycloalkyl), —N(C1-C6 alkyl)C(O)NH(C3-C8 cycloalkyl), —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl)(C3-C8 cycloalkyl), —NHC(O)N(C1-C6 alkyl)(C3-C8 cycloalkyl), —(C1-C6 alkoxy)-(C1-C6 thioalkoxy); —CO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with phenyl; —C(O)-furan; and imidazolyl; wherein R31 and R32 at each occurrence are independently selected from the group consisting of hydrogen, C1-C8 alkyl, C2-C8 alkenyl, hydroxy C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy C1-C6 alkyl, —(CH2)0-4—SO2—(C1-C6 alkyl) wherein the alkyl is optionally substituted with 1, 2, 3 or 4 independently selected halogen atoms; —(CH2)0-4—SO2-imidazolyl, —(C1-C6 alkyl)-C(O)NH2, —(C1-C6 alkyl)-C(O)NH(C1-C6 alkyl), —(C1-C6 alkyl)-C(O)N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)-NH2, —(C1-C6 alkyl)-NH(C1-C6 alkyl), —(C1-C6 alkyl)-N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)phenyl, —(C1-C6 alkyl)pyridyl, —C(O)furanyl, (C1-C6 alkyl)-tetrahydrofuran, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —CO2—(C1-C6 alkyl), —(C1-C6 alkyl)-furanyl, —(CH2)0-4—SO2-thienyl, -pyrrolidinyl-benzyl, —(C1-C6 thioalkoxy)-(C1-C6 alkyl), —C(O)—(C1-C6 alkyl), (C1-C6 alkoxy), —(C2-C6 alkenyloxy), —(C1-C6 alkyl)-CO2—(C1-C6 alkyl), and —C(O)-piperidinyl optionally substituted with C1-C6 alkyl; wherein the phenyl and pyridyl groups are unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, hydroxy, C1-C4 alkoxy, halogen, or R31, R32 and the nitrogen to which they are attached form a 5, 6, or 7 membered heterocycloalkyl or a 6 membered heteroaryl ring, each of which is optionally fused to a benzene, pyridine or pyrimidine ring and each of which is optionally substituted with C1-C6 alkoxy, hydroxy, hydroxy C1-C6 alkyl, C1-C4 alkoxy C1-C6 alkyl, —C(O)NH2, —C(O)NH—(C1-C6 alkyl)-phenyl; R33 at each occurrence is independently, H, NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl) (C1-C6 alkyl), N(C1-C6 alkyl)(phenyl), N(C1-C6 alkyl)(benzyl); R35 is phenyl, C3-C8 cycloalkyl, —S-phenyl, benzodioxole, thienyl, C1-C6 alkyl, furanyl, imidazolyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-(C5-C6 cycloalkyl), or (CH2)0-4CN; R40 is phenyl, -phenyl-pyridyl, biphenyl, -phenyl-benzothienyl, -phenyl-thienyl, -phenyl-furanyl, -phenyl-pyrimidinyl, -phenyl-isoxazolyl, —C(O)-pyridyl, —(C1-C4 alkyl)-O—C(O)NH-phenyl wherein the phenyl is optionally substituted with 1, 2, or 3 halogen atoms; —(C1-C4 alkyl)-O—C(O)N(C1-C6 alkyl)-phenyl, —(C1-C6 alkyl)-phenyl, —(C1-C4 alkyl)-SO2NH2, —(C1-C4 alkyl)-SO2NH(C1-C6 alkyl), —(C1-C4 alkyl)-SO2N(C1-C6 alkyl)(C1-C6 alkyl), —SO2NH2, —SO2NH(C1-C6 alkyl), —SO2N(C1-C6 alkyl)(C1-C6 alkyl), CN, —(CH2)0-4-(C3-C8 cycloalkyl), —(C1-C4 alkyl)-C(O)O—(C1-C4 alkyl), —(C1-C4 alkyl)-R33, C1-C10 alkyl, C2-C8 alkenyl, —(C1-C4 alkyl)-NHC(O)—(C1-C4 alkyl), —(CH2)0-4—C(O)NH2, —(CH2)0-4—C(0)NH(C1-C6 alkyl), —(CH2)0-4—C(O)N(C1-C6 alkyl)(C1-C6 alkyl), naphthyl, tetrahydronaphthyl, dihydronaphthyl, —(CH2)0-4-imidazolyl, —(CH2)0-4-pyrrolidinyl, oxazolidinone 3,4-dihydro-benzo[e][1,2]oxathiine 2,2-dioxide, R42 is H, C1-C6 alkyl optionally substituted with OH; benzyl; —NHC(O)—(C1-C6 alkyl); —NHC(O)-phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups; —CO2—(C1-C6 alkyl); —CO2-(benzyl); or —C(O)—(C1-C6 alkyl). 2. A compound according to claim 1 wherein R35 is phenyl, cyclohexyl, —S-phenyl, benzodioxole, thienyl, C3-C6 alkyl, furanyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-(C5-C6 cycloalkyl); R40 is phenyl, -phenyl-pyridine, biphenyl, -phenyl-benzothienyl, -phenyl-thienyl, -phenyl-furanyl, -phenyl-pyrimidinyl, -phenyl-isooxazolyl, —C(O)-pyridyl, —(C1-C4 alkyl)-O—C(O)NH-phenyl, —(C1-C4 alkyl)-O—C(O)N(C1-C6 alkyl)-phenyl, —(C1-C4 alkyl)-phenyl, —(C1-C4 alkyl)-SO2NH2, —(C1-C4 alkyl)-SO2NH(C1-C6 alkyl), —(C1-C4 alkyl)-SO2N(C1-C6 alkyl)(C1-C6 alkyl), CN, —(CH2)0-4—(C3-C8 cycloalkyl), —(C1-C4 alkyl)-C(O)O—(C1-C4 alkyl), —(C1-C4 alkyl)-R33, C1-C8 alkyl, —(C1-C4 alkyl)-NHC(O)—(C1-C4 alkyl), —(CH2)0-4—C(O)NH2, —(CH2)0-4—C(O)NH(C1-C6 alkyl), —(CH2)0-4—C(O)N(C1-C6 alkyl)(C1-C6 alkyl), tetrahydronapthyl, dihydronaphthyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C1-C4 alkyl, C1-C4 alkoxy, halo(C1-C4 alkyl), —O—(C1-C4 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —CHO, C1-C4 thioalkoxy, —NHSO2—(C1-C4 alkyl), —N(C1-C4 alkyl)SO2—(C1-C4 alkyl) wherein the alkyl groups are optionally substituted with 1, 2, or 3 halogens; OH, SO2R33, R33; R41 is H, cyclohexyl, phenyl, or C1-C6 alkyl optionally substituted with 1 or 2 groups that are phenyl, hydroxy, or C1-C4 thioalkoxy; and R42 is hydrogen or —CH2CN. 3. A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein R30 is selected from the group consisting of pyrazolopyrimidinyl, isoxazolyl, triazolopyridinyl, pyridyl, furyl, naphthothienyl, thiadiazolyl, thienopyrimidinonyl, oxazolidinyl, purinyl, oxaxolyl, thiazolyl, pyridazinonyl, thiazolyl, benzoindazole, imidazopyrazolyl, pyridyl, pyrazolopyridinyl, thienopyrazolyl, oxazolyl, indazolyl, pyrrolidinyl, thienopyridinyl, dioxodihydrobenzoisothiazolonyl, triazolopyrimidinyl, thienyl, and benzooxadiazolyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of C1-C10 alkyl optionally substituted with phenyl, hydroxy, hydroxy C1-C10 alkyl optionally substituted with phenyl or (C1-C4 alkyl)phenyl, C1-C6 alkoxy optionally substituted with 1 or 2 hydroxy groups, —C(O)NR31R32, —NR31—SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 R33 groups, —SO2—NH(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 R33 groups, —SO2—N(C1-C6 alkyl)(C1-C6 alkyl) wherein each alkyl group is optionally substituted with 1 or 2 R33 groups, —SO2—NH(C1-C6 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 groups that are independently C1-C4 alkoxy or halogen, —O—(C1-C6 alkyl)-phenyl, —(C1-C6 alkyl)-O-phenyl, —(C1-C6 alkyl)-O—(C1-C6 alkyl)-phenyl, triazolidine-3,5-dione, halogen, —NHC(O)NH2, —N(C1-C6 alkyl)C(O)NH2, —N(C1-C6 alkyl)C(O)NH(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl) (C1-C6 alkyl), —(C1-C6 alkyl)thienyl, —(C1-C6 alkyl)furanyl, —S—(C1-C6 alkyl) phenyl, —SO2NR31R32, —C(O)—NR31R32, —NR31R32, dithiane, —NHC(S)NH2, —NHC(S)NH(C1-C6 alkyl), —NHC(S)N(C1-C6 alkyl)(C1-C6 alkyl), —CO2(C1-C6 alkyl), tetrahydropyran, phenyl optionally substituted with 1 or 2 groups that are independently F, Cl or Br, pyridine, —C2-C4 alkynyl-phenyl, —O—C3-C6 cycloalkyl, —O—(C1-C6 alkyl)-R33, benzo[1,2,5]oxadiazole, —C(O)—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with NH2, N(C1-C6 alkyl), or N(C1-C6 alkyl)(C1-C6 alkyl); —C(O)NH-phenyl, —C(O)N(C1-C6 alkyl)-phenyl, 4,4-Dimethyl-4,5-dihydro-oxazole, —(C1-C6 alkyl)-S-pyridine, —(C1-C6 alkyl) —SO2-pyridine, —(C1-C6 thioalkoxy)-pyridine, wherein R31 and R32 at each occurrence are independently selected from the group consisting of hydrogen, C1-C6 alkyl, hydroxy C1-C6 alkyl, C1-C6 haloalkyl, —(C1-C6 alkyl)-C(O)NH2, —(C1-C6 alkyl)-C(O)NH(C1-C6 alkyl), —(C1-C6 alkyl) —C(O)N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)-NH2, —(C1-C6 alkyl)-NH(C1-C6 alkyl), —(C1-C6 alkyl)-N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)phenyl, —(C1-C6 alkyl)pyridyl, —C(O)furanyl, (C1-C6 alkyl)-tetrahydrofuran, wherein the phenyl and pyridyl groups are unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, hydroxy, C1-C4 alkoxy, halogen, or R31, R32 and the nitrogen to which they are attached form a 5, 6, or 7 membered heterocycloalkyl or a 6 membered heteroaryl ring, each of which is optionally fused to a benzene, pyridine or pyrimidine ring and each of which is optionally substituted with C1-C6 alkoxy, hydroxy, hydroxy C1-C6 alkyl, C1-C4 alkoxy C1-C6 alkyl, —C(O)NH2, —C(O)NH—(C1-C6 alkyl)-phenyl; R33 at each occurrence is independently, H, NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl) (C1-C6 alkyl), N(C1-C6 alkyl)(phenyl); R35 is phenyl, C3-C8 cycloalkyl, —S-phenyl, benzodioxole, thienyl, C1-C6 alkyl, furanyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-(C5-C6 cycloalkyl); R42 is H, C1-C6 alkyl, benzyl, —NHC(O)—(C1-C6 alkyl), or —NHC(O)-phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups, R55 is cyclohexyl; cyclopentyl; azepanone; phenyl; piperidinyl; —SO2-phenyl; pyrrolidinyl; or 4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine; wherein each is optionally substituted with —C(O)NH2; —C(O)NH(C1-C6 alkyl); —C(O)N(C1-C6 alkyl)(C1-C6 alkyl); C1-C6 alkoxycarbonyl; —O—(C1-C6 alkyl)-C(O)NR31R32; —(C1-C6 alkyl)-phenyl; 4,5-dihydro-2H-pyridazin-3-one; C5-C6 cycloalkyl which is optionally substituted with one CN group, phenyloxy wherein the phenyl group is optionally substituted with —NHC(O)C1-C6 alkyl, —N(C1-C6 alkyl)-C(O)C1-C6 alkyl, wherein R31, R32 and the nitrogen to which they are attached form a pyrrolidine, piperidine, piperazine, morpholine, or thiamorpholine ring, wherein each ring is pyrimidinyl, 3,4-dihydro-2H-benzo[e][1,2]thiazine 1,1-dioxide, pyridyl, or pyrimidyl, alkoxyalkyl, -phenyl-benzothienyl, -phenyl-cyclohexyl, -phenyl-cyclopentyl, -phenyl-(C1-C6 alkyl)-cyclopentyl, -phenyl-(C1-C6 alkyl)-cyclohexyl, -phenyl-oxazolyl, furanyl, tetrahydrofuranyl, 7-oxa-bicyclo[2.2.1]heptyl; -dihydro-1-H-pyrazolidinone-phenyl; -phenyl-bicyclo[2.2.1]heptyl; imidazo[2,1-b][1,3]thiazolyl; azepanonyl; piperidinyl, —(C1-C6 alkyl)-piperidinyl; bicyclo[2.2.1]heptyl; chromanonyl, —(C1-C6 alkyl)-morpholinyl; -phenyl-C(O)-piperidinyl; tetrahydrothiazolopyridinyl, -pyrrolo-C(O)-pyrrolidinyl; -phenyl-C(O)-phenyl; -phenyl-O-phenyl; -phenyl-O-benzyl; -phenyl-tetrahydropyridazinonyl; and -phenyl-dihydropyridazinonyl; wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C1-C8 alkyl optionally substituted with 1 or two groups that are independently CN or OH; C1-C6 alkoxy, halo(C1-C8 alkyl), halo(C1-C4 alkoxy), —O—(C1-C4 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, CN, —CHO, C1-C4 thioalkoxy, —NHSO2—(C1-C6 alkyl), —N(C1-C4 alkyl)SO2—(C1-C4 alkyl) wherein the alkyl groups are optionally substituted with 1, 2, or 3 halogens; OH; —SO2R33; R33; C2-C8 alkynyl; C2-C8 alkenyl; thioalkoxyalkyl; —SO2—(C1-C10 alkyl); —NR31R32; —C(O)—NR31R32; —OC(O)R33; C1-C8 alkanoyl; and —(C1-C6 alkyl)-C(O)—(C1-C6 alkoxy), —C(O)—(C1-C6 alkoxy); —O—(C1-C6 alkyl)-C(O)NR31R32; —CO2—(C1-C6 alkyl); R41a and R41 are independently H, cyclohexyl, phenyl, or C1-C6 alkyl optionally substituted with 1 or 2 groups that are phenyl, hydroxy, C1-C4 thioalkoxy, C1-C4 thioalkoxy C1-C6 alkyl; or —C1-C6 alkyl-SO2—C1-C6 alkyl; or R40, R41, and the atom to which they are attached form a C3-C8 cycloalkyl ring which is optionally substituted with C1-C4 alkyl, C1-C4 alkoxy, halogen, —CO2NH2, —CO2NH(C1-C6 alkyl), or —CO2N(C1-C6 alkyl)(C1-C6 alkyl); a thiazolyl ring which is optionally substituted with C1-C6 alkyl; isoxazolyl ring which is optionally substituted with C1-C6 alkyl; phenyl which is optionally substituted with 1, 2, or 3 groups that are independently halogen or C1-C6 alkyl; -pyrrolidinyl-benzyl; piperidinyl optionally substituted with 1 or 2 groups that are independently —CO2—(C1-C6 alkyl) or —C(O)—(C1-C6 alkyl); and unsubstituted or substituted with 1, 2, or 3 groups that are independently OH, C1-C6 alkyl, C1-C6 alkoxy, —(C1-C6 alkyl)-imidazole wherein the imidazole is optionally substituted with 1 or 2 C1-C4 alkyl groups, or hydroxy (C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 phenyl ring, or R42, R55 and the nitrogen to which they are attached form a tetrahydroisoquinolinyl, dihydroisoquinolinyl, or isoquinolinyl group which is optionally substituted by 1, 2, 3, or 4 groups that are independently halogen, C1-C4 alkyl, C1-C4 alkoxy, CN, OH, and phenyl, wherein the phenyl is optionally substituted with halogen, hydroxyl, C1-C4 alkoxy, and C1-C4 alkyl. 4. A compound according to claim 3 wherein R30 is selected from the group consisting of pyridyl, furyl, and thienyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of C1-C10 alkyl, hydroxy, hydroxy C1-C10 alkyl C1-C6 alkoxy, —NR31—SO2—(C1-C6 alkyl), —SO2—NH(C1-C6 alkyl), —SO2—N(C1-C6 alkyl)(C1-C6 alkyl), halogen, —NHC(O)NH2, —N(C1-C6 alkyl)C(O)NH2, —N(C1-C6 alkyl)C(O)NH(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl)(C1-C6 alkyl), —SO2NR31R32, —C(O)—NR31R32, —NR31R32, —C2-C4 alkynyl-phenyl, —O—C3-C6 cycloalkyl, —O—(C1-C6 alkyl)-R33, benzo[1,2,5]oxadiazole, —C(O)—(C1-C6 alkyl; wherein R31 and R32 at each occurrence are independently selected from the group consisting of hydrogen, C1-C6 alkyl, hydroxy C1-C6 alkyl, C1-C6 haloalkyl, —(C1-C6 alkyl)-C(O)NH2, —(C1-C6 alkyl)-C(O)NH(C1-C6 alkyl), —(C1-C6 alkyl)-C(O)N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)-NH2, —(C1-C6 alkyl)-NH(C1-C6 alkyl), —(C1-C6 alkyl)-N(C1-C6 alkyl)(C1-C6 alkyl), benzyl, and —C(O)furanyl, wherein the phenyl and pyridyl groups are unsubstituted or substituted with 1, 2, or 3, groups that are independently C1-C4 alkyl, hydroxy, C1-C4 alkoxy, or halogen, or R31, R32 and the nitrogen to which they are attached form a 5, 6, or 7 membered heterocycloalkyl or a 6 membered heteroaryl ring, each of which is optionally substituted with C1-C6 alkoxy, hydroxy, hydroxy C1-C6 alkyl, C1-C4 alkoxy C1-C6 alkyl, or —C(O)NH2; R35 is phenyl, C3-C6 cycloalkyl, or —S-phenyl, each of which is unsubstituted or substituted with 1, 2, or 3 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, CF3, OCF3, halogen, —Obenzyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-(C5-C6 cycloalkyl); R42 is H, C1-C6 alkyl, benzyl, —NHC(O)—(C1-C6 alkyl), or —NHC(O)-phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups, R55 is cyclohexyl; azepanone; phenyl; piperidinyl; —SO2-phenyl; pyrrolidinyl; or 4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine; wherein each is optionally substituted with —C(O)NH2; C1-C6 alkoxycarbonyl; —O—(C1-C6 alkyl)-C(O)NR31R32; —(C1-C6 alkyl)-phenyl; 4,5-dihydro-2H-pyridazin-3-one; cyclopentyl which is optionally substituted with one CN group, phenyloxy wherein the phenyl group is optionally substituted with —NHC(O)C1-C6 alkyl, wherein R31, R32 and the nitrogen to which they are attached form a pyrrolidine, piperidine, piperazine, or morpholine ring, wherein each ring is unsubstituted or substituted with 1, 2, or 3 groups that are independently OH, —(C1-C6 alkyl)-imidazole wherein the imidazole is optionally substituted with 1 or 2 C1-C4 alkyl groups, or hydroxy (C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 phenyl ring, or R42, R55 and the nitrogen to which they are attached form a tetrahydroisoquinolinyl, group which is optionally substituted by 1, 2, 3, or 4 groups that are independently halogen, C1-C4 alkyl, C1-C4 alkoxy, CN, OH, and phenyl, wherein the phenyl is optionally substituted with halogen, hydroxyl, C1-C4 alkoxy, and C1-C4 alkyl. 5. A compound according to claim 3 wherein R35 is phenyl; halophenyl, dihalophenyl; trihalophenyl; tetrahalophenyl; pentahalophenyl; phenyl substituted with one halogen and one benzyloxygroup; phenyl substituted with one halogen and one alkyl group; benzyloxyphenyl; cyclohexyl; (C1-C4 alkoxy)carbonylphenyl; (C1-C4 alkoxy)phenyl; —S-phenyl, or benzodioxole; R40 is phenyl, or —(C1-C4 alkyl)-SO2NH2, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, methyl, ethyl, methoxy, ethoxy, or —Obenzyl wherein the phenyl is optionally substituted with 1 or 2 halogens, R42 is H. 6. A compound according to claim 1 wherein R30 is pyridyl or pyrimidyl wherein each is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of C1-C10 alkyl optionally substituted with 1 phenyl or 1 CN; OH, hydroxy C1-C10 alkyl optionally substituted with phenyl or (C1-C4 alkyl)phenyl, C1-C6 alkoxy optionally substituted with 1 or 2 groups that are independently hydroxy or phenyl; haloalkyl, haloalkoxy, (CH2)0-4C(O)NR31R32, —NR31—SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 groups that are independently halogen or R33, —SO2—NH(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, alkoxy, or R33; —(C1-C6 alkyl)-SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, C1-C4 alkoxy, or R33; —SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently OH or C1-C4 alkoxy, —SO2—N(C1-C6 alkyl)(C1-C6 alkyl) wherein each alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH or R33; —SO2—NH(C1-C6 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 groups that are independently C1-C4 alkoxy or halogen, —(C1-C6 alkyl)-O-phenyl, —(C1-C6 alkyl)-O—(C1-C6 alkyl)-phenyl, triazolidine-3,5-dione, halogen, —NHC(O)NH2, —NHC(O)NH(C1-C6 alkyl), —NHC(O)N(C1-C6 alkyl)(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)NH2, —N(C1-C6 alkyl)C(O)NH(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)thienyl, —(C1-C6 alkyl)furanyl, —S—(C1-C6 alkyl)phenyl, —SO2NR31R32, —C(O)—NR31R32, —NR31R32, dithiane, —NHC(S)NH2, —NHC(S)NH(C1-C6 alkyl), —NHC(S)N(C1-C6 alkyl)(C1-C6 alkyl), —CO2(C1-C6 alkyl), tetrahydropyran, phenyl optionally substituted with 1 or 2 groups that are independently F, Cl or Br; pyridine, —C2-C4 alkynyl-phenyl, —O—C3-C8 cycloalkyl, —O—(C1-C6 alkyl)-R33; pyrrole optionally substituted with one or two methyl groups; 2,3-dihydro-benzofuran; benzo[1,2,5]oxadiazole, —C(O)—(C1-C10 alkyl) wherein the alkyl group is optionally substituted with NH2, N(C1-C6 alkyl), or N(C1-C6 alkyl)( C1-C6 alkyl); —C(O)NH-phenyl, —C(O)N(C1-C6 alkyl)-phenyl, 4,4-dimethyl-4,5 -dihydro-oxazole, —(C1-C6 alkyl)-S-pyridine, —(C1-C6 alkyl)-SO2-pyridine, —(C1-C6 thioalkoxy)-pyridine, thiazole optionally substituted with 1 or 2 methyl groups, pyrazole, —S—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently CN or OH; indole, (C1-C6 thioalkoxy)-(C1-C6 alkyl), C2-C8 alkynyl, -(CH2)04—SO2—(C1-C10 alkyl) wherein the alkyl group is optionally substituted with OH; —NHC(O)NH(C3-C8 cycloalkyl), —N(C1-C6 alkyl)C(O)NH(C3-C8 cycloalkyl), —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl)(C3-C8 cycloalkyl), —NHC(O)N(C1-C6 alkyl)(C3-C8 cycloalkyl), —(C1-C6 alkoxy)-(C1-C6 thioalkoxy); —CO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with phenyl; —C(O)-furan; and imidazolyl; wherein R31 and R32 at each occurrence are independently selected from the group consisting of hydrogen, C1-C8 alkyl, C2-C8 alkenyl, hydroxy C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy C1-C6 alkyl, —(CH2)0-4—SO2—(C1-C6 alkyl) wherein the alkyl is optionally substituted with 1, 2, 3 or 4 independently selected halogen atoms; —(CH2)0-4—SO2-imidazolyl, —(C1-C6 alkyl)-C(O)NH2, —(C1-C6 alkyl)-C(O)NH(C1-C6 alkyl), —(C1-C6 alkyl)-C(O)N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)-NH2, —(C1 -C6 alkyl)-NH(C1-C6 alkyl), —(C1 -C6 alkyl)-N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)phenyl, —(C1-C6 alkyl)pyridyl, —C(O)furanyl, (C1-C6 alkyl)-tetrahydrofuran, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —CO2—(C1-C6 alkyl), —(C1-C6 alkyl)-furanyl, —(CH2)0-4—SO2-thienyl, -pyrrolidinyl-benzyl, —(C1-C6 thioalkoxy)-(C1-C6 alkyl), —C(O)—(C 1-C6 alkyl), (C1-C6 alkoxy), —(C2-C6 alkenyloxy), —(C1-C6 alkyl)-CO2—(C1-C6 alkyl), and —C(O)-piperidinyl optionally substituted with C1-C6 alkyl; wherein the phenyl and pyridyl groups are unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, hydroxy, C1-C4 alkoxy, halogen, or R31, R32 and the nitrogen to which they are attached form a 5, 6, or 7 membered heterocycloalkyl or a 6 membered heteroaryl ring, each of which is optionally fused to a benzene, pyridine or pyrimidine ring and each of which is optionally substituted with C1-C6 alkoxy, hydroxy, hydroxy C1-C6 alkyl, C1-C4 alkoxy C1-C6 alkyl, —C(O)NH2, —C(O)NH—(C1-C6 alkyl)-phenyl; R33 at each occurrence is independently, H, NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl) (C1-C6 alkyl), N(C1-C6 alkyl)(phenyl), N(C1-C6 alkyl)(benzyl); R35 is phenyl; halophenyl, dihalophenyl; trihalophenyl; tetrahalophenyl; pentahalophenyl; phenyl substituted with one halogen and one benzyloxy group; phenyl substituted with one halogen and one alkyl group; benzyloxyphenyl; cyclohexyl; (C1-C4 alkoxy)carbonylphenyl; (C1-C4 alkoxy)phenyl; —S-phenyl, or benzodioxole; and R40 is phenyl, -phenyl-pyridine, biphenyl, -phenyl-benzothienyl, -phenyl-thienyl, -phenyl-furanyl, -phenyl-pyrimidinyl, -phenyl-isoxazolyl, —(C1-C4 alkyl)-O—C(O)NH-phenyl, —(C1-C4 alkyl)-O—C(O)N(C1-C6 alkyl)-phenyl, —(C1-C4 alkyl)-SO2NH2, CN, —(C1-C4 alkyl)-(C3-C6 cycloalkyl), —(C1-C4 alkyl)-C(O)O—(C1-C4 alkyl), —(C1-C4 alkyl)-R33, C1-C8 alkyl, pyridyl, or pyrimidyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently halogen, C1-C4 alkyl, C1-C4 alkoxy, CF3, —O—(C1-C4 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —CHO, or —NHSO2—(C1-C4 alkyl). 7. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein R30 is selected from the group consisting of pyrazolopyrimidinyl, isoxazolyl, triazolopyridinyl, pyridyl, furyl, naphthothienyl, thiadiazolyl, thienopyrimidinonyl, oxazolidinyl, pyrazinyl mono N-oxide, benzofuranyl, pyrazolyl, -isoxazolyl-phenyl, benzimidazolyl, indolyl, isoquinolinyl, -thienyl-thienyl, benzothienyl, quinolinyl, thieno[2,3-b)]thiophene, benzoxazole; benzo[b]thiophene 1,1-dioxide; isoindolyl, purinyl, oxaxolyl, thiazolyl, pyridazinonyl, thiazolyl, benzoindazole, imidazopyrazolyl, pyridyl N-oxide, pyrazolopyridinyl, thienopyrazolyl, oxazolyl, indazolyl, thienopyridinyl, triazolopyrimidinyl, thienyl, and benzooxadiazolyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of C1-C10 alkyl optionally substituted with 1 phenyl or 1 CN; OH, hydroxy C1-C10 alkyl optionally substituted with phenyl or (C1-C4 alkyl)phenyl, C1-C6 alkoxy optionally substituted with 1 or 2 groups that are independently hydroxy or phenyl; haloalkyl, haloalkoxy, (CH2)0-4C(O)NR31R32, —NR31—SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 groups that are independently halogen or R33, —SO2—NH(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, alkoxy, or R33; —(C1-C6 alkyl)-SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, C1-C4 alkoxy, or R33; —SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently OH or C1-C4 alkoxy, —SO2—N(C1-C6 alkyl)(C1-C6 alkyl) wherein each alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH or R33; —SO2—NH(C1-C6 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 groups that are independently C1-C4 alkoxy or halogen, —O—(C1-C6 alkyl)-phenyl, —(C1-C6 alkyl)-O-phenyl, —(C1-C6 alkyl)-O—(C1-C6 alkyl)-phenyl, triazolidine-3,5-dione, halogen, —NHC(O)NH2, —NHC(O)NH(C1-C6 alkyl), —NHC(O)N(C1-C6 alkyl)(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)NH2, —N(C1-C6 alkyl)C(O)NH(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)thienyl, —(C1-C6 alkyl)furanyl, —S—(C1-C6 alkyl)phenyl, —SO2NR31R32, —C(O)—NR31R32, —NR31R32, dithiane, —NHC(S)NH2, —NHC(S)NH(C1-C6 alkyl), —NHC(S)N(C1-C6 alkyl)(C1-C6 alkyl), —CO2(C1-C6 alkyl), tetrahydropyran, phenyl optionally substituted with 1 or 2 groups that are independently F, Cl or Br; pyridine, —C2-C4 alkynyl-phenyl, —O—C3-C8cycloalkyl, —O—(C1-C6 alkyl)-R33; pyrrole optionally substituted with one or two methyl groups; 2,3-dihydro-benzofuran; benzo[1,2,5]oxadiazole, —C(O)—(C1-C10 alkyl) wherein the alkyl group is optionally substituted with NH2, N(C1-C6 alkyl), or N(C1-C6 alkyl)(C1-C6 alkyl); —C(O)NH-phenyl, —C(O)N(C1-C6 alkyl)-phenyl, 4,4-dimethyl-4,5-dihydro-oxazole, —(C1-C6 alkyl)-S-pyridine, —(C1-C6 alkyl)-SO2-pyridine, —(C1-C6 thioalkoxy)-pyridine, thiazole optionally substituted with 1 or 2 methyl groups, pyrazole, S—(C1-C6 alkyl), indole, (C1-C6 thioalkoxy)-(C1-C6 alkyl), C2-C8 alkynyl, —CO2—(C1-C6 alkyl), C1-C10 alkanoyl; —(CH2)0-4—SO2—(C1-C10 alkyl) wherein the alkyl group is optionally substituted with OH; wherein R31 and R32 at each occurrence are independently selected from the group consisting of hydrogen, C1-C8 alkyl, C2-C8 alkenyl, hydroxy C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy C1-C6 alkyl, —(CH2)0-4—SO2—(C1-C6 alkyl) wherein the alkyl is optionally substituted with 1, 2, 3 or 4 independently selected halogen atoms; —(CH2)0-4—SO2-imidazolyl, —(C1-C6 alkyl)-C(O)NH2, —(C1-C6 alkyl)-C(O)NH(C1-C6 alkyl), —(C1-C6 alkyl)-C(O)N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)-NH2, —(C1-C6 alkyl)-NH(C1-C6 alkyl), —(C1-C6 alkyl)-N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)phenyl, —(C1-C6 alkyl)pyridyl, —C(O)furanyl, (C1-C6 alkyl)-tetrahydrofuran, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —CO2—(C1-C6 alkyl), —(C1-C6 alkyl)-furanyl, —(CH2)0-4—SO2-thienyl , wherein the phenyl and pyridyl groups are unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, hydroxy, C1-C4 alkoxy, halogen, or R31, R32 and the nitrogen to which they are attached form a 5, 6, or 7 membered heterocycloalkyl or a 6 membered heteroaryl ring, each of which is optionally fused to a benzene, pyridine or pyrimidine ring and each ofwhich is optionally substituted with C1-C6 alkoxy, hydroxy, hydroxy C1-C6 alkyl, C1-C4 alkoxy C1-C6 alkyl, —C(O)NH2, —C(O)NH—(C1-C6 alkyl)-phenyl; R33 at each occurrence is independently, H, NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl) (C1-C6 alkyl), N(C1-C6 alkyl)(phenyl), N(C1-C6 alkyl)(benzyl); R35 is phenyl, C3-C8 cycloalkyl, —S-phenyl, benzodioxole, thienyl, C1-C6 alkyl, furanyl, imidazolyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-( C5-C6 cycloalkyl), or (CH2)0-4CN; R42 is H, C1-C6 alkyl optionally substituted with OH; benzyl; —NHC(O)—(C1-C6 alkyl); —NHC(O)-phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups; and R48 is —C(O)R49, wherein R49 is phenyl, or C1-C8 alkyl, each of which is optionally substituted with halogen, C1-C4 alkoxy, C1-C4 alkyl, or R33 . 8. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is C1-C4 alkyl, C2-C4 alkynyl, or CF3; R2 and R3 are both hydrogen; or R2 and R3 and the carbon to which they are attached form a cyclopropyl ring; R4 is oxazolyl optionally substituted with methyl, thiazolyl, C2-C4 alkynyl, or C1-C4 alkyl; R5 is C1-C4 alkyl; R6 is C1-C4 alkyl; X and Y are independently halogen; Z is N. 9. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein X is nitrogen; R1 is C2-C3 alkyl, amino, mono(C1-C3)alkylamino, di(C1-C3)alkylamino, amino(C1-C3)alkyl, mono(C1-C3)alkylamino(C1-C2)alkyl, or di(C1-C3)alkylamino(C1-C2)alkyl; R2 and R3 are both hydrogen; or Rf and Rg are both hydrogen or independently halogen; R5 and R6 are independently methyl or C2-C3-C4 alkyl, where at least one of R5 and R6 is not methyl. 10. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein one of X or X1 is nitrogen or N+—O− while the other is CH; R1 is C2-C4 alkynyl, cyano, or C1-C3 alkyl; R2 and R3 are both hydrogen; or R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached; Rf and Rg are independently halogen; Rp is hydrogen, C1-C2 alkyl, or oxazolyl; and R5 and R6 are independently C3-C4 alkyl. 11. A compound according to claim 10, wherein X is nitrogen; R1 is C2-C3 alkynyl; R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached; and Rp is C1-C2 alkyl. 12. A compound according to claim 10, wherein X is nitrogen; R1 is C1-C2 alkyl; R2 and R3 are hydrogen; and Rp is hydrogen, C1-C2 alkyl, cyano or oxazol-2-yl. 13. A compound according to claim 10, wherein X is nitrogen; R1 is C2-C3 alkyl; R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached; and Rp is C1-C2 alkyl. 14. A compound according to claim 11, wherein Rf and Rg are both chloro or fluoro; and R5 and R6 are independently propyl or butyl. 15. A compound according to claim 1 of the formula or a pharmaceutically acceptable salt thereof, wherein Z is CH and the dashed line represents a double bond; R1 is C2-C3 alkyl; R2 and R3 are both hydrogen; Rf and Rg are independently halogen; Rp is hydrogen, cyano, C1-C3 alkyl, amino, —(CH2)0-4—N(—H or RN-5)—SO2—RN-2, 2-oxazolyl, or 1-pyrrolyl optionally substituted in the 2 and 5 positions with C1-C2 alkyl; Rj is C1-C5 alkyl RN-2 is —C1-C8 alkyl optionally substituted with —NR′R″; RN-5 is hydrogen or (C1-C3)alkyl; and R′ and R″ at each occurrence are the same or different and are —H, C1-C4 alkyl. 16. A compound of according to claim 1 the formula or a pharmaceutically acceptable salt thereof, wherein Z is R1 is C1-C3 alkyl or halogen; R2 and R3 are both hydrogen; R5 is C1-C3 alkylsulfonyl, C1-C3 alkylsulfonyl(C1-C3)alkyl, —NHSO2(C1-C2 alkyl), or —N(C1-C2 alkyl)SO2(C1-C2 alkyl); and Rf and Rg are independently halogen. 17. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein X is nitrogen or N+—O−; R1 is C2-C4 alkynyl or C1-C3 alkyl; R2 and R3 are both hydrogen; or R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached; Rf and Rg are independently halogen; Rp is hydrogen or C1-C2 alkyl; and R5 and R6 are independently C3-C4 alkyl. 18. A compound according to claim 17, wherein X is nitrogen; Rp is C1-C2 alkyl; and R1 is ethyl. 19. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is C2-C3 alkynyl or C1-C3 alkyl; Rf and Rg are independently halogen; R5 and R6 are independently C1-C4 alkyl. 20. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein one of X and X′ is CH and the other is N; R1 is C2-C4 alkynyl; amino(C1-C3)alkyl, mono(C1-C3)alkylamino(C1-C2)alkyl, or di(C1-C3) alkylamino(C1-C2)alkyl; R2 and R3 are both hydrogen; or R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached; Rf and Rg are independently halogen; R5 and R6 are independently C1-C3-C4 alkyl. 21. A compound according to claim 1 of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is C2-C3 alkyl; R2 and R3 are both hydrogen; Rf and Rg are independently halogen; Rp is hydrogen, cyano, C1-C3 alkyl, amino, N—(C1-C3 alkylsulfonyl)-N—((C1-C3)alkyl)amino, 2-oxazolyl, or 1-pyrrolyl optionally substituted in the 2 and 5 positions with C1-C2 alkyl; Ra is C1-C3 alkyl; and Rj is C1-C5 alkyl. 22. A compound according to claim 1 of the formula or a pharmaceutically acceptable salt thereof, wherein X is nitrogen or N+—O−; R1 is C2-C4 alkynyl, cyano, C1-C3 alkyl, or CF3; R2 and R3 are both hydrogen; or R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached; Rf and Rg are independently halogen; Rp is hydrogen, or C1-C2 alkyl; and R5 and R6 are independently C1-C4 alkyl. 23. A compound according to claim 22, wherein X is N. 24. A compound according to claim 1 which is N4-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide; 2-(2,5-Dimethyl-pyrrol-1-yl)-thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 4-Phenyl-[1,2,3]thiadiazole-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Methanesulfonylamino-oxazole-4-carboxylic acid {1-benzyl-3-[N-ethyl-N′-(3-ethyl-benzoyl)-hydrazino]-2-hydroxy-propyl}-amide; 2-Methanesulfonylamino-oxazole-4-carboxylic acid {1-benzyl-3-[N-ethyl-N′-(4-methyl-pentanoyl)-hydrazino]-2-hydroxy-propyl}-amide; 4-Acetylamino-1-methyl-1H-pyrrole-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Ethyl-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Methanesulfonylamino-oxazole-4-carboxylic acid [3-(N′-acetyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-amide; 2-Methanesulfonylamino-oxazole-4-carboxylic acid [3-(N′-benzoyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-amide; 6-Methyl-4-oxo-1-phenyl-1,4-dihydro-pyridazine-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Methanesulfonylamino-thiazole-4-carboxylic acid {1-benzyl-3-[N-ethyl-N′-(3-ethyl-benzoyl)-hydrazino]-2-hydroxy-propyl}-amide; 4-Methyl-2-phenyl-oxazole-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Methanesulfonylamino-thiazole-4-carboxylic acid [3-(N′-acetyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-amide; 2-p-Tolyl-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Phenoxymethyl-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; [1,2,5]Thiadiazole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-m-Tolyl-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-(2-Chloro-phenyl)-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Acetylamino-5-chloro-thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl -benzylamino)-2-hydroxy-propyl]-amide; 4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 1-(4-Fluoro-phenyl)-5-methyl-1H-[1,2,4]triazole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 6-Chloro-4-trifluoromethyl-pyridine-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 4-Methoxy-thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2,5-Dimethyl-1-pyridin-4-ylmethyl-1H-pyrrole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Methyl-5-thiophen-2-yl-furan-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 3-Chloro-5-phenyl-isothiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-5-phenylethynyl-nicotinamide; 4,7-Dimethoxy-benzofuran-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; [1,6]Naphthyridine-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 8-Cyano-4-hydroxy-quinoline-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Pyridin-3-yl-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 5-Chloro-benzofuran-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-nicotinamide; 4-Chloro-6-methyl-quinoline-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Methyl-pyrimidine-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 4-Methyl-oxazole-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 1H-Indole-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 6-Chloro-1H-indole-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; Thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Methyl-oxazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 6-Hydroxy-2-methylsulfanyl-pyrimidine-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2,5-Dimethyl-furan-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-nicotinamide; Furan-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 1H-Indole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; [2,3′]Bithiophenyl-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 5-Methoxy-thiophene-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 4-Phenyl-thiophene-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Oxo-2,3-dihydro-benzooxazole-6-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; Thieno[3,2-c]pyridine-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 1-Methyl-1H-indole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; Benzo[b]thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 4-Oxy-3-propyl-pyrazine-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 1,1,3-Trioxo-2,3-dihydro-1H-116-benzo[d]isothiazole-6-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; 2-Hydroxy-6-methyl-quinoline-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyisoxazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,8-dimethylquinoline-3-carboxamide; 3-(benzyloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoxazole-5-carboxamide; 4-[(butylthio)methyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3,4,5-tetrahydrothiopyrano[4,3-b ]indole-8-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dimethyl-2-(1H-pyrrol-1-yl)thiophene-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-6-(1-hydroxy-2,2-dimethylpropyl)pyridine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2′-bithiophene-5-carboxamide; 3-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(methylsulfonyl)thiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino])-2-hydroxypropyl}-5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dimethoxy-1-benzothoniophene-2-carboxamide; 5-(benzylthio)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}nicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-pyrazole-5-carboxamide; 6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-benzimidazole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxy-4, 7-dimethoxy-1-benzofuran-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,3-dihydro-1-benzofuran-5-yl)-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-hex-1-ynylnicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methoxyisoxazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dimethyl-1H-indole-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)}-5-methyl-3-phenylisoxazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-fluorobenzoyl)-1H-pyrrole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(ethylthio)nicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[2,3-b]quinoline-2-carboxamide; N-{2-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]phenyl}-N-methyl-2-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-hydroxy-1H-indole-2-carboxamide; 6-benzyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide 4-oxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-fluoro-2-hydroxyquinoline-4-carboxamide; 6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxyquinoline-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoxazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,6-diethoxypyridine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dithian-2-yl)-3-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylthiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-indole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7-fluoro-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzofuran-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-4-oxo-4H-chromene-6-carboxamide; N-[6-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-6-oxohexyl]-2-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}indolizine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}nicotinamide 1-oxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-1H-pyrazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-pyridin-2-ylthiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-isobutyl-1,3-dioxoisoindoline-5-carboxamide; 5-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoquinoline-4-carboxamide; 7-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzofuran-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1H-indol-3-yl)-1H-pyrazole-5-carboxamide; 6-cholo-N—{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2hydroxypropyl}nicotinamide; 3-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-fluoro-1H -indole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dihydronaphtho[2,1-d]isoxazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-benzo[g]indazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxy-1H-pyrrole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-9-oxo-1,2,3,9-tetrahydrocyclopenta[b]chromene-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxy-1-benzofuran-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-imidazo[1,2-b]pyrazole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-benzimidazole-5-carboxamide; 7-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methylquinoline-5-carboxamide; N-{(1S 2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-5-phenyl-1H-pyrazole-3-carboxamide; 6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide 4-oxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxypyrazine-2-carboxamide 4-oxide; 5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1-benzofuran-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-1-pyridin-4-yl-1H-1,2,3-triazole-4-carboxamide; 2-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-3,4-dihydroquinazoline-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide 4-oxide; 7-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-2-carboxamide; 5-(4-chlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-furamide; 4-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1H-pyrrol-1-yl)thiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,5-bis(methylthio)isothiazole-4-carboxamide; 4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide; N-{2-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]phenyl}-5-methyl-2-furamide; 1-(cyanomethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-pyrrole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,5-dimethyl-1-phenyl-1H-pyrrole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(piperidin-1-ylmethyl)-2-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2,3-dihydro-1-benzothiophene-2-carboxamide 1,1-dioxide; 2-(2,1,3-benzoxadiazol-5-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dihydrofuro[2,3-g][2,1]benzisoxazole-8-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-3-carboxamide; 4,5-dichloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isothiazole-3-carboxamide; 8-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxycinnoline-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,6-dioxohexahydropyrimidine-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylimidazo[1,2-a]pyridine-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1, 3-dimethyl-1H-thieno[2,3-c]pyrazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-1,3-oxazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-7-methoxy-1-benzofuran-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-7-methoxy-1-benzothiophene-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-6-neopentylpyridine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(4-fluorophenyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-3-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-phenyl-1,3-oxazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyquinoxaline-2-carboxamide; 2-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dimethylthiophene-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-ethyl-1H-indole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzofuran-2-carboxamide; 1-benzyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,5-dimethyl-1H-pyrazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,8-dihydroxyquinoline-2-carboxamide; methyl 5-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-1H-benzimidazol-2-ylcarbamate; N-{1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[ethyl(methyl)amino]-4-hydroxypyrimidine-5-carboxamide; 2-(diethylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxypyrimidine-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxy-4-methylpyridine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxyoropyl}-2-phenylimidazo [1,2-a]pyridine-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methoxy-1H-indole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisoxazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methylisoxazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxynicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxyquinoline-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[3,2-b]pyridine-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[2,3-c]pyridine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)thiophene-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(trifluoromethoxy)-1H-indole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(pyridin-2-ylthio)methyl]-2-furamide; 5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-morpholin-4-ylpyrimidine-4-carboxamide; 5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-1-phenyl-1H-pyrazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,1,3-benzoxadiazole-5-carboxamide; 2-(acetylamino)-N-{(1R,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-1,3-oxazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1,3-dihydro-2,1-benzisothiazole-5-carboxamide 2,2-dioxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)}-2,2-dimethylchromane-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(2-methoxyethyl)(methylsulfonyl)amino]nicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(3-hydroxypropyl)(methylsulfonyl)amino]nicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(2-hydroxyethyl)(methylsulfonyl)amino]nicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(2-methoxyethyl)(methylsulfonyl)amino]nicotinamide; N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-N3 N3-dipropylbenzene-1,3,5-tricarboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-methoxyethyl)(methylsulfonyl)amino]isonicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(2-methoxyethyl)(methylsulfonyl)amino]nicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(3-hydroxypropyl)(methylsulfonyl)amino]isonicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-hydroxyethyl)(methylsulfonyl)amino]isonicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(3-hydroxypropyl)(methylsulfonyl)amino]nicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(3-hydroxypropyl)(methylsulfonyl)amino]nicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(3-methoxypropyl)(methylsulfonyl)amino]isonicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(3-methoxypropyl)(methylsulfonyl)amino]nicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)-1H-indole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)indoline-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)indoline-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)indoline-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)-1H-indole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1-benzothiophene-5-carboxamide 1,1-dioxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-5-carboxamide1,1-dioxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1-benzothiophene-3-carboxamide 1,1-dioxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-6-carboxamide1,1-dioxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2,3-dihydro-1,2-benzisothiazole-5-carboxamide 1,1-dioxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-dihydro-2,1-benzisothiazole-6-carboxamide 2,2-dioxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dioxoisoindoline-5-carboxamide; 1-benzyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-imidazole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)thiophene-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-isobutyl-1,3-dioxoisoindoline-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[2,3-c]pyridine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[3,2-b]pyridine-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,3-dihydro-1H-indol-1-yl)-4-oxobutanamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dithian-2-yl)-3-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl})-2-methyl-5,6,7,8-tetrahydro-4H-pyrazolo [1,5-a]azepine-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(4-fluorophenyl)-1,4,5,6-tetrahydrocyclopenta[a]pyrazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)}-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5,6,7-tetrahydro-2H-indazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7-fluoro-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxo-2,3-dihydro-1H-indazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dimethyl-1H-thieno[2,3-c]pyrazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,6-dioxohexahydropyrimidine-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,7-dimethoxy-1-oxoindane-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-3-carboxamide; 2-[(cyanomethyl)thio]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}nicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dihydrofuro[2,3-g][2,1]benzisoxazole-8-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3,4,5-tetrahydrothiopyrano[4,3-b]indole-8-carboxamide; 4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-8H-thieno[2,3-b]indole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,5-benzodioxepine-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4H-chromeno[3,4-d]isoxazole-4-carboxamide; 4-(3,4-dichlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxoisoindoline-1-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4H-chromeno [3,4-d]isoxazole-8-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-4-oxo-4H-chromene-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-ethyl-3-oxoisoindoline-1-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-imidazo[1,2]pyrazole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-9-oxo-1,2,3,9-tetrahydrocyclopenta[b]chromene-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)}-1-methyl-1H-benzo[g]indazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dihydronaphtho[2,1-d]isoxazole-3-carboxamide; N-[(1S,2R)-3-(2-acetyl-1-ethylhydrazino)-1-benzyl-2-hydroxypropyl]-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-2-[((methylsulfonyl)amino]-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,8-dimethylquinoline-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyisoxazole-5-carboxamide; N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxammide; N4-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxammide; N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxammide; N4-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxammide; N4-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxammide; 2-[allyl(methylsulfonyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-5-carboxammide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-6-(1-hydroxy-2,2-dimethylpropyl)pyridine-2-carboxammide; 1-(cyanomethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-pyrrole-2-carboxammide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(dipropylamino)isoquinoline-7-carboxammide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxammide; N2-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dimethyl-N5,N5-dipropylthieno[2,3-b]thiophene-2,5-dicarboxammide; N3-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-ylamino)propyl]-N5,N5-diisopropylpyridine-3,5-dicarboxammide; or 2-[ally(methylsulfonyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-oxazole-4-carboxammide; or a pharmaceutically acceptable salt thereof. 25. A compound according to claim 1 of the formula: wherein Ra and Rd are independently C1-C6 alkyl; X is O or S; Rb and Rc are independently hydrogen or halogen; Re is C1-C6 alkyl or an optionally substituted phenyl. 26. A compound which is: N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(dipropylamino)isoquinoline-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxamide; N2-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dimethyl-N5,N5-dipropylthieno[2,3-b]thiophene-2,5-dicarboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyl-1,3-benzoxazole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-benzoxazole-6-carboxamide; N4-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide; N4-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-isopropyl-1,3-benzoxazole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isonicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyl-1,3-benzoxazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-isopropyl-1,3-benzoxazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-benzoxazole-7-carboxamide; N-4-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-benzoxazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyl-1,3-benzoxazole-4-carboxamide; 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-propyl-1H-indole-6-carboxamide; 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-5-carboxamide; 1-butyl-N -{(1S,2 R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}indoline-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl }-2,3-dihydro-1,4-benzodioxine-6-carboxamide; 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indazole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-thien-2-yl-1,3-thiazole-4-carboxamide; 5-(aminosulfonyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-pyrrole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-{[(2-furylmethyl)sulfonyl]methyl}-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-{[(4-fluorobenzyl)sulfonyl]methyl}-1,3-thiazole-4-carboxamide; 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[methyl(methylsulfonyl)amino]-1H-indole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoquinoline-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(propylamino)isoquinoline-7-carboxamide or N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(propylamino)isoquinoline-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(3-hydroxypropyl)-1H-indole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-6-(pyrrolidin-1-ylcarbonyl)isonicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)isonicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)isonicotinamide; N-{(1S ,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-[methyl(propyl)amino]isoquinoline-7-carboxamide or N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-[methyl(propyl)amino]isoquinoline-7-carboxamide; N5-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropyl-1H-pyrazole-3,5-dicarboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-methoxyethyl)-1H-indole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,8-diethoxyquinoline-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-6-methylpyrimidine-4-carboxamide; 1-[butyl(methyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoquinoline-7-carboxamide or 1-[butyl(methyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoquinoline-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dihydro-2-benzothiophene-5-carboxamide 2,2-dioxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-isobutyl-1H-indole-6-carboxamide; 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-indole-6-carboxamide; 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-1H-indole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxo-2-propyl-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide; 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,3-oxazol-2-yl)-1H-indole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-6-methylisonicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(methylsulfonyl)methyl]-1,3-thiazole-4-carboxamide; 4-amino-1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-ethyl-3-oxo-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide; 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide; methyl 2-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-6-methylisonicotinate; N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide 1-oxide; 1-butyl-4-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide; 1-butyl-4-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1,3-dihydro-2,1-benzisothiazole-5-carboxamide 2,2-dioxide; 2-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methylisonicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-isopentyl-1H-indole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyl-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-ethyl-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide; 6-bromo-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-8-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(methylsulfonyl)methyl]thiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-6-methylisonicotinamide; 6-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-8-carboxamide; 3-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-indole-5-carboxamide; 3-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-5-carboxamide; 1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-1H-benzimidazole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(methylsulfonyl)methyl]nicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-6-(1,3-oxazol-2-yl)isonicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-6-(1,3-oxazol-2-yl)isonicotinamide; 1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-1H-benzimidazole-5-carboxamide; N-{(1S,2R)-3-[(3-ethylbenzyl)amino]-1-[3-(hexyloxy)benzyl]-2-hydroxypropyl}-2-1(methylsulfonyl)amino-1,3-oxazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(methylsulfonyl)methyl]nicotinamide; 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-1H-pyrrole-2-carboxamide; N2-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methyl-N4,N4-dipropylpyridine-2,4-dicarboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,1-dipropyl-3,4-dihydro-1H-isochromene-7-carboxamide; 2-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroisoquinoline-7-carboxamide; 1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(2-methoxyethyl)-1H-benzimidazole-6-carboxamide; N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(dipropylamino)-6-(1,3-oxazol-2-yl)isonicotinamide; 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)-1,2,3,4-tetrahydroquinoxaline-6-carboxamide; 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoquinoline-7-carboxamide; 5-{[butyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-6-(1,3-thiazol-2-yl)isonicotinamide; N-{(1S,2R)-1-(3-butoxybenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxamide; 3-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}imidazo[1,2-a]pyridine-6-carboxamide; 2-[butyl(methyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-(1,3-oxazol-2-yl)isonicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-benzodioxole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[methyl(propyl)amino]-6-(1,3-oxazol-2-yl)isonicotinamide; 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzothiazine-6-carboxamide; 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroiuinoxaline-6-carboxamide; N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(dipropylamino)isonicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-4-methyl-1,3-thiazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-3-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide; 1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-1H-indole-6-carboxamide; 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxyproypyl}-1,2,3,4-tetrahydroisoquinoline-7-carboxamide; 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzothiazine-6-carboxamide 1-oxide; 2-[butyl(methyl)amino]-6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isonicotinamide; 2-[butyl(methyl)amino]-6-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isonicotinamide; 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-8-(1,3-oxazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide or 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-8-(1,3-oxazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide; 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroquinoline-7-carboxamide or 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroquinoline-7-carboxamide; N-{(1S 2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-propyl-1,2-benzisoxazole-5-carboxamide; 2-[allyl(methyl)amino]-N-{(1S,2R)-1-[3-(allyloxy)-5-fluorobenzyl]-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isonicotinamide; 3-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2-benzisoxazole-5-carboxamide; N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-pyrrolidin-1-ylpyrazine-2-carboxamide; 4-butoxy-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethybenzyl)amino]-2-hydroxypropyl}qouinoline-2-carboxamide; 2-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[methyl(propyl)amino]isonicotinamide; 3-acetyl-1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-isobutyl-1,2-benzisoxazole-5-carboxamide; 4,5-dibromo-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-2-carboxamide; N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2,6-bis(dimethylamino)pyrimidine-4-carboxamide; 4-butyl-8-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide; 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(trifluoroacetyl)-1H-indole-6-carboxamide; N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(dipropylamino)-1-methyl-1H-pyrrole-2-carboxamide; 2,6-dichloro-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)pyrimidine-4-carboxamide; N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-morpholin-4-yl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide; 2-chloro-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-morpholin-4-ylpyrimidine-4-carboxamide; N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(dipropylamino)-6-morpholin-4-ylpyrimidine-4-carboxamide; N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2,6-bis(dipropylamino)pyrimidine-4-carboxamide; or pharmaceutically acceptable salts thereof. 27. A compound that is: N′-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-N,N-dipropylpyridine-3,5-dicarboxamide; N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,N-dipropylpyridine-3,5-dicarboxamide 1-oxide; N4-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide; N-{(1S 12R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-imidazole-2-carboxamide; tert-butyl 2-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-1-methyl-1H-imidazol-4-ylcarbamate; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,1,3-benzoxadiazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxyoropyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxyoropyl}-5-[(pyridin-2-ylthio)methyl]-2-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(trifluoromethoxy)-1H-indole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,8-dimethylquinoline-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-6-methylquinoline-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-propylpyrazine-2-carboxamide 4-oxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-indole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxy-1,3-benzothiazole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-phenylthiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methoxythiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3′-bithiophene-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}nicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxyquinoline-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxynicotinamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-2-carboxamide; 7-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxyquinoline-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methylisoxazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisoxazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methoxy-1H-indole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,5-dimethyl-3-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxy-2-(methylthio)pyrimidine-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-oxazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-1H-pyrazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-3-carboxamide; 6-chloro-N-{1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-1,3-oxazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methylpyrimidine-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylimidazo[1,2-a]pyridine-7-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxy-4-methylpyridine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[ethyl(methyl)amino]-4-hydroxypyrimidine-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,8-dihydroxyquinoline-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzofuran-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-ethyl-1H-indole-2-carboxamide; 2-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dimethylthiophene-3-carboxamide; N-{(1S,2R)-1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyquinoxaline-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-phenyl-1,3-oxazole-4-carboxamide; 4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methylquinoline-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-furamide; N-{(1S,2R)-1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-3-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-6-neopentylpyridine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-7-methoxy-1-benzothiophene-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-7-methoxy-1-benzofuran-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-1,3-oxazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-7-methoxyquinoline-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylimidazo[1,2-a]pyridine-6-carboxamide; N-{(1S,2R)-1-(3,5-difiuorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxyoropyl}-5-(piperidin-1-ylmethyl)-2-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,5-dimethyl-1-phenyl-1H-pyrrole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,5-bis(methylthio)isothiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(trifluoromethyl)isoxazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-1H-pyrrole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide 4-oxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-1-pyridin-4-yl-1H-1,2,3-triazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxypyrazine-2-carboxamide 4-oxide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-5-phenyl-1H-pyrazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-benzimidazole-5-carboxamide; 5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzofuran-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-pyridin-3-yl-1,3-thiazole-4-carboxamide; 8-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxyquinoline-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,6-naphthyridine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethyl-4-oxochromane-6-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,7-dimethoxy-1-benzofuran-5-carboxamide; 3-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-phenylisothiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxy-1-benzofuran-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxy-1H-pyrrole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-5-(2-thienyl)-3-furamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxythiophene-3-carboxamide; 6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(trifluoromethyl)pyridine-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(4-fluorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-methoxyphenyl)thiophene-2-carboxamide; 2-(acetylamino)-5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-3-carboxamide; 4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7,7-dimethyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine-2-carboxamide; 2-(2-chlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-methylphenyl)-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,5-thiadiazole-3-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(phenoxymethyl)-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-methylphenyl)-1,3-thiazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-pyridin-3-ylbenzamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-2-phenyl-1,3-oxazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-ethyl-3-(2-thienyl)-1H-pyrazole-5-carboxamide; 4-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-pyrrole-2-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-phenyl-1,2,3-thiadiazole-5-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,5-dimethyl-1H-pyrrol-1-yl)thiophene-3-carboxamide; N-{(1S,2R)-1-benzyl-3-[1-ethyl-2-(4-methylpentanoyl)hydrazino]-2-hydroxypropyl}-2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxamide; N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-imidazole-2-carboxamide; 6-(4-benzylpiperazin-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}nicotinamide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[2,3-b]quinoline-2-carboxamide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine-4-carboxamide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxo-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[3,2-c]pyridine-2-carboxamide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-oxo-2,3-dihydro-1,3-benzoxazole-6-carboxamide 6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-5-carboxamide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}indolizine-2-carboxamide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(phenylethynyl)nicotinamide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,5-dimethyl-1-(pyridin-4-ylmethyl)-1H-pyrrole-3-carboxamide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-5-carboxamide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,1,3-benzoxadiazole-5-carboxamide 1-oxide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4a,9a-dihydro-9H-carbazole-9-carboxamide N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methyl-4-oxo-1-phenyl-1,4-dihydropyridazine-3-carboxamide or a pharmaceutically acceptable salt thereof.