A syringe for use in a pressurized injection of a fluid includes a syringe barrel including a polymeric material having undergone expansion via blow molding. An inner diameter of the syringe barrel can, for example, be sufficiently constant (over at least a portion of the axial length of the syringe
A syringe for use in a pressurized injection of a fluid includes a syringe barrel including a polymeric material having undergone expansion via blow molding. An inner diameter of the syringe barrel can, for example, be sufficiently constant (over at least a portion of the axial length of the syringe) that a plunger slidably positioned within the syringe barrel and in generally sealing contact with an inner wall of the syringe barrel can be used within the syringe barrel to generate a pressure of at least 1 psi within the syringe barrel. In several embodiment, the inner diameter of the syringe barrel is sufficiently constant to generate a pressure of at least 100 psi, at least 300 psi, or even at least 500 psi within the syringe barrel. A method of forming a syringe includes the steps of: injection molding at least one polymeric material to form a preform; placing the preform into an blow mold die; and expanding at least a portion of the preform while heating the preform within the die to form a barrel of the syringe. The syringes can be formed to withstand relatively high pressures as described above. The at least one polymeric material can, for example, be polyethyleneterephthalate, cyclic olefin polymer, polypropylene, polystyrene, polyvinylidene chloride, polyethylene napthalate and/or nylon.
대표청구항▼
What is claimed is: 1. A method of forming a syringe, comprising: injection molding at least one polymeric material to form a preform that is open at both ends, wherein injection molding the preform comprises: forming an open-ended syringe tip defining a syringe outlet at a distal end of the prefor
What is claimed is: 1. A method of forming a syringe, comprising: injection molding at least one polymeric material to form a preform that is open at both ends, wherein injection molding the preform comprises: forming an open-ended syringe tip defining a syringe outlet at a distal end of the preform, forming a barrel section in fluid connection with the syringe outlet via a passage between the barrel section and the syringe outlet, and forming an opening at a proximal end of the preform in connection with the barrel section; placing the preform into a blow mold die; and expanding at least a portion of the preform within the die, wherein expanding a portion of the preform comprises: extending a stretch rod through the opening in the proximal end of the preform and into a rearward portion of the syringe tip to seal the syringe outlet; forcing a gas within the preform; preventing the gas from entering the syringe tip; and further extending the stretch rod within the preform to form a barrel of the syringe. 2. The method of claim 1 further comprising heating the at least a portion of the preform to be expanded before placing the preform into the blow mold die. 3. The method of claim 1 further comprising heating the at least a portion of the preform during expansion within the die. 4. The method of claim 1 further comprising a heat setting process. 5. The method of claim 1 wherein injection molding the preform further comprises forming a retention mechanism on a proximal end of the syringe adapted to connect the syringe to a powered injector, the retention mechanism comprising at least one flange. 6. The method of claim 5 wherein the retention mechanism is not substantially altered during the expansion of the preform. 7. The method of claim 1 wherein injection molding the preform further comprises forming a connector adjacent the distal end of the preform. 8. The method of claim 7 wherein the connector is not substantially altered during expansion of the preform. 9. The method of claim 1 wherein the at least one polymeric material comprises polyethyleneterephthalate, cyclic olefin polymer, polypropylene, polystyrene, polyvinylidene chloride, polyethylene napthalate or nylon. 10. The method of claim 1 wherein injection molding the preform further comprises forming a removable closure on a distal end of the syringe outlet. 11. The method of claim 10 wherein the closure is removably connected to the syringe outlet via a wall section of reduced thickness. 12. The method of claim 1 wherein an inner diameter of a wall of the syringe barrel does not vary by greater than 0.007 in. over the axial length of the syringe. 13. The method of claim 1 wherein an inner diameter of a wall of the syringe barrel does not vary by greater than 0.01 in. over the axial length of the syringe. 14. The method of claim 1 wherein an inner diameter of a wall of the syringe barrel does not vary by greater than 0.004 in. over the axial length of the syringe. 15. A method of forming a syringe, comprising: injection molding at least one polymeric material to form a preform that is open at both ends, wherein injection molding the preform comprises: forming an open-ended syringe tip defining a syringe outlet having a precision molded connector at a distal end of the preform; forming a barrel section in fluid connection with the syringe outlet; and forming a second opening at a proximal end of the preform that is in fluid connection with the barrel section; placing the preform into a blow mold die; and stretch blow molding the preform within the die, wherein stretch blow molding the preform comprises: extending a stretch rod through the second opening in the proximal end of the preform and into engagement with a rearward portion of the syringe tip to seal the syringe outlet; forcing a gas within the preform; preventing the gas from entering the syringe tip, thereby maintaining the syringe outlet and the precision molded connector in an unaltered state; and further extending the stretch rod within the preform to extend the preform axially and form the barrel of the syringe. 16. The method of claim 15, further comprising: heating the preform before placing the preform into the blow mold die. 17. The method of claim 15, further comprising: heating the preform during stretch blow molding of the preform. 18. The method of claim 15 wherein injection molding the preform further comprises forming a retention flange on a proximal end of the syringe. 19. The method of claim 18 wherein the retention flange is not substantially altered during stretch blow molding of the preform. 20. The method of claim 15 wherein the at least one polymeric material comprises polyethyleneterephthalate, cyclic olefin polymer, polypropylene, polystyrene, polyvinylidene chloride, polyethylene napthalate or nylon. 21. The method of claim 15 wherein an inner diameter of a wall of the barrel section does not vary by greater than 0.01 in. over the axial length of the syringe. 22. The method of claim 15 wherein the precision molded connector is formed with a male luer taper and luer threading. 23. The method of claim 15, further comprising: heat setting the stretch blow molded syringe.
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이 특허에 인용된 특허 (14)
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