IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0179385
(2005-07-12)
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등록번호 |
US-7740795
(2010-07-12)
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발명자
/ 주소 |
- Wang, Kathy K.
- Dong, Nicholas Nai Guang
- Meehan, Michael
|
출원인 / 주소 |
- Howmedica Osteonics Corp.
|
대리인 / 주소 |
Lerner, David, Littenberg, Krumholz & Mentlik, LLP
|
인용정보 |
피인용 횟수 :
17 인용 특허 :
48 |
초록
▼
The invention relates to implantable medical devices, particularly, to porous structures for such devices. In one aspect, the invention provides a porous metal scaffold comprising a porous metal network having pores defined by metal webs, the metal webs covered with at least one layer of metal parti
The invention relates to implantable medical devices, particularly, to porous structures for such devices. In one aspect, the invention provides a porous metal scaffold comprising a porous metal network having pores defined by metal webs, the metal webs covered with at least one layer of metal particles bonded to the metal webs. In other aspects, the invention provides methods of forming porous scaffolds. In one such aspect, the method includes providing a polymer foam; forming a skin of biocompatible metal on the polymer foam by low temperature arc vapor deposition; and heating the polymer foam and the metal skin above the decomposition temperature of the polymer foam in an inert gas atmosphere; thereby the polymer foam decomposes producing a green metal foam. In yet other aspects, the invention provides methods of improving stability of porous scaffolds.
대표청구항
▼
The invention claimed is: 1. A method of forming a porous scaffold for use in an implantable medical device, said method comprising: a) providing a polymer foam having a pre-determined thickness and webs defining a pore size ranging from about 500 μm to about 2000 μm; b) forming a skin
The invention claimed is: 1. A method of forming a porous scaffold for use in an implantable medical device, said method comprising: a) providing a polymer foam having a pre-determined thickness and webs defining a pore size ranging from about 500 μm to about 2000 μm; b) forming a skin of biocompatible metal on the webs of said polymer foam by low temperature arc vapor deposition LTAVD); c) heating said polymer foam and said metal skin above the decomposition temperature of said polymer foam in an inert gas atmosphere to decompose the polymer foam to form a porous metal network; and thickening webs of the porous metal network by applying a solution of a binder onto said webs, applying a biocompatible metal powder having a particle size of between 40 and 80 μm to the webs of the porous metal network, and sintering said metal powder covered metal network to form a porous coating on the webs to produce a porous scaffold wherein the webs define a pore size of 100 to 1000 μm. 2. The method of claim 1, wherein said thickening of said porous metal network is accomplished by applying the metal powder in a plurality of steps until said metal network has said pore size defined by the coated webs of 100 to 1000 μm. 3. The method of claim 1, wherein said pre-determined thickness of said polymer foam is between about 0.5 mm and about 10 mm. 4. The method of claim 3, wherein said pre-determined thickness of said polymer foam is between about 1 mm and about 5 mm. 5. The method of claim 3, wherein said pre-determined thickness is between about 1 mm and about 2 mm. 6. The method of claim 1, wherein said polymer foam is a polyurethane foam. 7. The method of claim 1, wherein said polymer foam has a pore size ranging from about 500 μm to about 2000 μm. 8. The method of claim 1, wherein said metal skin has thickness between about 1 μm and about 50 μm. 9. The method as set forth in claim 8 wherein, after the LTAVD step, the polymer foam webs have a first side and a second side with both sides having a metal skin. 10. The method of claim 9, wherein the thickness of said metal skin is about 35 μm on said first side and about 10 μm on said second side. 11. The method of claim 1, wherein said binder solution is an aqueous solution of methyl cellulose. 12. The method of claim 9, wherein after said heating of said metal webs the metal skin surrounds an empty core. 13. The method of claim 2, wherein said pre-determined pore size of said porous metal network is between about 300 μm and about 500 μm. 14. The method of claim 1, wherein said metal is selected from the group consisting of titanium, titanium alloy, cobalt chrome alloy, niobium and tantalum. 15. The method of claim 2, wherein the particle covered webs of the metal network include portions having a diameter of 20 to 100 microns. 16. A method of forming a porous scaffold for use in an implantable medical device, said method comprising: a) providing a polymer foam having a pre-determined thickness and webs defining a first pore size; b) forming a metal skin of biocompatible metal on said webs by low temperature arc vapor deposition of the metal; c) decomposing said polymer foam in an inert gas atmosphere thereby forming a porous metal network of metal webs; d) pre-sintering said porous metal network; e) contacting said pre-sintered metal webs with biocompatible metal particles in the presence of a binder, the particles having a size between 40 and 80 μm to form a porous coating on the webs; f) bonding said metallic particles to said pre-sintered metal webs to obtain a porous scaffold having pores defined by the particle coated webs defining a second pore size of between 100 and 1000 μm. 17. The method of claim 16, wherein said pre-determined thickness of said polymer foam is from about 0.5 mm to about 2 mm. 18. The method of claim 16, wherein said first pore size is from about 500 μm to about 2000 μm. 19. The method of claim 16, wherein said inert atmosphere is argon atmosphere. 20. The method of claim 16, wherein said second pore size is from about 100 μm to about 1000 μm. 21. The method of claim 16, wherein said metal particles and said pre-sintered porous metal network are bonded by sintering. 22. The method of claim 16, wherein the metal of said porous metal scaffold is selected from the group consisting of titanium, titanium alloy, cobalt chrome alloy, niobium and tantalum. 23. The method of claim 16, wherein the metal of said metal particles is selected from the group consisting of titanium, titanium alloy, cobalt chrome alloy, niobium and tantalum. 24. The method as set forth in claim 16 further comprising applying a biocompatible coating to the porous scaffold. 25. The method as set forth in claim 16 wherein the particle covered webs of the metal scaffold include portions having a diameter of 40 to 80 microns. 26. The method as set forth in claim 16 wherein after the decomposing of the polymer foam the metal skin network surrounds an empty core.
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