Repair of ruptured membrane by injection of naturally occurring protein in amniotic fluid sac
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-017/08
A61K-035/54
출원번호
UP-0144472
(2002-05-13)
등록번호
US-7744625
(2010-07-19)
발명자
/ 주소
Berry, David
대리인 / 주소
Fulbright & Jaworski L.L.P.
인용정보
피인용 횟수 :
0인용 특허 :
6
초록▼
The present invention provides compositions and methods for use in treatment of premature rupture of membrane. The compositions of the invention include a therapeutic amount of an avian thick egg white composition. Preferably, the compositions include the purified thick egg white protein, ovomucin.
The present invention provides compositions and methods for use in treatment of premature rupture of membrane. The compositions of the invention include a therapeutic amount of an avian thick egg white composition. Preferably, the compositions include the purified thick egg white protein, ovomucin. The methods of the invention involve injecting an effective amount of the compositions into the prematurely ruptured amniotic sac of a patient in order to seal the rupture.
대표청구항▼
What is claimed is: 1. A method of sealing a ruptured amniotic membrane comprising introducing an effective amount of a composition composed of one or more egg white proteins into an amniotic fluid sac of a mammal, wherein the one or more egg white proteins is selected from the group consisting of
What is claimed is: 1. A method of sealing a ruptured amniotic membrane comprising introducing an effective amount of a composition composed of one or more egg white proteins into an amniotic fluid sac of a mammal, wherein the one or more egg white proteins is selected from the group consisting of ovomucin, ovalbumin, avidin, ovoflavoprotein, ovomacroglobulin, ovotransferrin, ovomucoid, ovoinhibitor, and lysozyme. 2. The method of claim 1, wherein the egg white protein is ovomucin. 3. The method of claim 2, wherein the ovomucin is substantially purified. 4. The method of claim 2, wherein the composition comprises ovomucin in the range of 1 to 90 percent by weight. 5. The method of claim 1, wherein the egg white protein is from chicken thick egg white. 6. The method of claim 1, wherein the composition further comprises a pharmaceutically acceptable carrier. 7. The method of claim 6, wherein the pharmaceutically acceptable carrier is selected from the group consisting of water, ethanol, and polyol. 8. The method of claim 7, wherein the polyol is selected from the group consisting of glycerol, propylene glycol, and liquid polyethylene glycol. 9. The method of claim 1, wherein the composition is sterile. 10. The method of claim 1, wherein the composition is injected into the amniotic fluid sac. 11. The method of claim 10, wherein the composition is amnioinfused into the amniotic fluid sac. 12. The method of claim 1, wherein the composition further comprises one or more antibiotics, or bacterial inhibiting substances. 13. A method of enhancing the integrity of a ruptured amniotic membrane comprising introducing a composition comprising ovomucin into an amniotic fluid sac of a mammal. 14. The method of claim 13, wherein the ovomucin is substantially purified. 15. The method of claim 13, wherein the composition further comprises a pharmaceutically acceptable carrier. 16. The method of claim 15, wherein the pharmaceutically acceptable carrier is selected from the group consisting of water, ethanol, and polyol. 17. The method of claim 16, wherein the polyol is selected from the group consisting of glycerol, propylene glycol, and liquid polyethylene glycol. 18. The method of claim 13, wherein the composition comprises ovomucin in the range of 1 to 90 percent by weight. 19. The method of claim 13, wherein the composition is sterile. 20. The method of claim 13, wherein the composition is injected into the amniotic fluid sac. 21. The method of claim 20, wherein the composition is amnioinfused into the amniotic fluid sac. 22. The method of claim 13, wherein the composition further comprises one or more antibiotics, or bacterial inhibiting substances.
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이 특허에 인용된 특허 (6)
Oborn Robert Edward (Cincinnati OH), Egg white composition.
Yahiaoui Ali ; Lindon Jack Nelson ; Garavaglia Arthur Edward ; Leach Crystal Sutphin ; Hetzler Connie Lynn ; Woltman Garry Roland ; Potts David Charles, Treatment of materials to improve handling of viscoelastic fluids.
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