초록 ▼

A bioabsorbable implantable endoprosthesis having elongate elements including hollow, cavity or porous portions adapted to accumulate by-product from the degradation of the bioabsorbable material and shortening the diffusion distance for water absorption and thereby relatively increasing the degrada

A bioabsorbable implantable endoprosthesis having elongate elements including hollow, cavity or porous portions adapted to accumulate by-product from the degradation of the bioabsorbable material and shortening the diffusion distance for water absorption and thereby relatively increasing the degradation of the structure.

대표청구항 ▼

The invention claimed is: 1. A bioabsorbable endoprosthesis comprising: a plurality of elongate elements interbraided into a tubular, radially expandable structure, each of the elongate elements having an outer surface, the elements including a bioabsorbable polymer adapted to undergo degradation i

The invention claimed is: 1. A bioabsorbable endoprosthesis comprising: a plurality of elongate elements interbraided into a tubular, radially expandable structure, each of the elongate elements having an outer surface, the elements including a bioabsorbable polymer adapted to undergo degradation in vivo, the elements including an elongate, axially extending reservoir portion adapted to collect a by-product of the degradation of the bioabsorbable polymer; wherein the each of the elements occupies a total element volume including a reservoir volume occupied by the at least one reservoir portion, and the reservoir volume is at least about ten percent of the total element volume; the number of elements, N, is equal to about (D/(0.022D+0.17))±4 filaments, where D, in mm, is the free state diameter of the tubular structure; and the elongate elements have a thickness, t in mm, of about (D/(1.8D+15))±0.03 mm, where D, in mm, is the free state diameter of the tubular structure. 2. The endoprosthesis of claim 1 wherein: the reservoir portion comprises at least one axially extending internal cavity recessed from the outer surface. 3. The endoprosthesis of claim 2 wherein: the at least one cavity occupies a cavity volume ranging from about ten percent to about thirty percent of the total element volume. 4. The endoprosthesis of claim 2 wherein: an average cross-sectional area of the cavity ranges from about ten percent to about thirty percent of a cross-sectional area of the elongate element. 5. The endoprosthesis of claim 1 wherein: the volume of the reservoir portion ranges from twenty percent to about forty percent of the total element volume. 6. The endoprosthesis of claim 1 wherein: the plurality of elongate elements are interbraided at crossing angles ranging from about 120 degrees to about 150 degrees. 7. The endoprosthesis of claim 1 wherein: the bioabsorbable polymer consists essentially of a polymer from the group consisting of: PLLA, PDLA, and their combinations. 8. The endoprosthesis of claim 1 wherein: the bioabsorbable polymer consists essentially of a polymer selected from the group consisting of: polylactide, polyglycolide, and their combinations. 9. The endoprosthesis of claim 1 wherein: the bioabsorbable polymer consists of a polymer selected from the group consisting of: polyglycolide, polygluconate, polydioxanone, and their combinations. 10. The endoprosthesis of claim 1 wherein: the number of elements, N, is from about 10 to about 36 filaments. 11. The endoprosthesis of claim 1 wherein: the reservoir portion comprises at least one axially extending core open to opposite ends of the element.