초록 ▼

The present invention provides curable materials, medical devices incorporating such materials, wherein the curable materials are capable of releasing hydrolyzable leaving agents upon hydrolysis that can form agents (e.g., pharmaceutically active agents), and methods of making and using such materia

The present invention provides curable materials, medical devices incorporating such materials, wherein the curable materials are capable of releasing hydrolyzable leaving agents upon hydrolysis that can form agents (e.g., pharmaceutically active agents), and methods of making and using such materials and devices.

대표청구항 ▼

What is claimed is: 1. An implantable medical device comprising a coating, the coating comprising a curable material comprising a prepolymer comprising at least one silicon atom and at least one hydrolyzable leaving group bonded to at least one silicon atom, the hydrolyzable leaving group being fre

What is claimed is: 1. An implantable medical device comprising a coating, the coating comprising a curable material comprising a prepolymer comprising at least one silicon atom and at least one hydrolyzable leaving group bonded to at least one silicon atom, the hydrolyzable leaving group being free of acidic hydrogen atoms, wherein upon hydrolysis of the prepolymer, the prepolymer forms a curable intermediate and the hydrolyzable leaving group is released, and wherein the released hydrolyzable leaving group is a salicylic moiety, wherein the implantable medical device is designed to remain in a subject for more than 28 days. 2. The device of claim 1 wherein the prepolymer comprises a monomer, an oligomer, a polymer, or mixtures thereof. 3. The device of claim 1 wherein the curable intermediate forms a biocompatible polymer upon condensation in the body of a subject. 4. The device of claim 1, wherein the curable intermediate comprises at least two silanol groups. 5. The device of claim 1 wherein the prepolymer is a polymer and further comprises a poly(alkylene oxide) segment, a polysiloxane segment, a polyester segment, a poly(vinyl pyrrolidone) segment, a polyacrylate segment, a polymethacrylate segment, a polycarbonate segment, a hydrocarbon segment, a polycarbosilane segment, a fluoropolymeric segment, a polyoxazoline segment, or mixtures or copolymers thereof. 6. The device of claim 1 wherein the prepolymer comprises one or more silicon atoms per one hydrolyzable group. 7. The device of claim 6 wherein the hydrolyzable group is a terminal group bonded to the silicon atom. 8. The device of claim 1 wherein the prepolymer comprises one silicon atom per one or two hydrolyzable groups. 9. The device of claim 1 wherein the prepolymer comprises one silicon atom per one to three hydrolyzable groups. 10. The device of claim 1 wherein the prepolymer comprises two silicon atoms per one hydrolyzable group. 11. The device of claim 10 wherein the hydrolyzable group is bonded to the two silicon atoms to forma linear polymer. 12. The device of claim 10 wherein the hydrolyzable group is attached to the two silicon atoms to form a ring. 13. The device of claim 1 wherein the prepolymer comprises one or more silicon-bonded hydrolyzable leaving groups pendant from a polymeric chain. 14. The device of claim 1 wherein the curable material further comprises particulate material. 15. The device of claim 1, wherein the curable material is injectable. 16. The device of claim 14, wherein the particulate material is selected from the group consisting of a moisture curing ceramic material, an inorganic material, a polymer microsphere material, a solid polymer particulate material, an imaging particulate material, a woven fiber and a non-woven fiber. 17. An implantable medical device comprising a curable material comprising a prepolymer made from a polymerizable monomer selected from the group consisting of: a compound of the formula: a compound of the formula combinations thereof; wherein upon hydrolysis of the prepolymer, the prepolymer forms a curable intermediate and the hydrolyzable leaving group is released, and wherein the released hydrolyzable leaving group is a salicylic moiety, wherein the implantable medical device is designed to remain in a subject for more than 28 days. 18. An implantable medical device comprising a curable material comprising a prepolymer selected from the group consisting of: a material of the formula a material of the formula a material of the formula combinations thereof; wherein upon hydrolysis of the prepolymer, the prepolymer forms a curable intermediate and a hydrolyzable leaving group is released, and wherein the released hydrolyzable leaving group is a salicylic moiety, wherein the implantable medical device is designed to remain in a subject for more than 28 days.