초록 ▼

Methods of using pomegranate extracts of the present invention for treating patients with atherosclerosis, or increased intima-media thickness of an artery, are provided. The methods comprise the step of administering to the patient a composition comprising a therapeutically effective amount of an e

Methods of using pomegranate extracts of the present invention for treating patients with atherosclerosis, or increased intima-media thickness of an artery, are provided. The methods comprise the step of administering to the patient a composition comprising a therapeutically effective amount of an extract from pomegranate. The methods of the present invention may also be used to decrease the incidence of stroke or heart attack in a patient.

대표청구항 ▼

What is claimed is: 1. A process for producing a therapeutically effective amount of an extract from pomegranate, wherein said extract is prepared by a process comprising: crushing and squeezing whole fruits of pomegranate including inner and outer peels and seeds to yield a juice component and an

What is claimed is: 1. A process for producing a therapeutically effective amount of an extract from pomegranate, wherein said extract is prepared by a process comprising: crushing and squeezing whole fruits of pomegranate including inner and outer peels and seeds to yield a juice component and an insoluble by-product component; separating said juice component from said insoluble by-product component; resuspending said insoluble by-product component in an aqueous medium; crushing, squeezing and mixing said insoluble by-product component in said aqueous medium to yield a soluble portion and an insoluble portion; and separating said soluble portion to produce an extract comprising said soluble portion. 2. A pharmaceutical composition comprising the extract of claim 1 and a pharmaceutically acceptable carrier. 3. The pharmaceutical composition of claim 2, wherein said pharmaceutical composition is a supplement. 4. A pharmaceutical composition comprising the extract of claim 1 and a pharmaceutical carrier, wherein said composition comprises at least 30 to 3000 micromols per dosage unit of polyphenols. 5. The pharmaceutical composition of claim 4, wherein said pharmaceutical composition is a supplement. 6. The process of claim 1, further comprising: measuring a dosage unit of said extract using polyphenols as a measurement marker. 7. The process of claim 6, wherein said dosage unit comprises at least 30 micromols of said polyphenols. 8. The process of claim 6, wherein said dosage unit comprises at least 3000 micromols of said polyphenols. 9. The process of claim 6, further comprising adding said dosage unit to a beverage. 10. The process of claim 1, further comprising: adding said extract to a beverage. 11. The process of claim 10, wherein said extract contains at least 30 micromols of natural pomegranate polyphenols. 12. The process of claim 10, wherein said extract contains at least 3000 micromols of natural pomegranate polyphenols. 13. A process for producing a therapeutically effective amount of an extract from pomegranate, wherein said extract is prepared by a process comprising: crushing whole fruits of pomegranate including inner and outer peels and seeds to yield a juice component and an insoluble by-product component; separating said juice component from said insoluble by-product component; resuspending said insoluble by-product component with an aqueous medium; mixing said resuspended insoluble by-product component and said aqueous medium; and separating an aqueous extract from said insoluble by-product component, wherein said aqueous extract comprises a therapeutically effective amount of polyphenols resulting from said insoluble by-product component. 14. The process of claim 13, wherein said therapeutically effective amount of polyphenols is between 30 to 3000 micromols per dosage unit. 15. A pharmaceutical composition comprising the extract of claim 14 and a pharmaceutically acceptable carrier. 16. The pharmaceutical composition of claim 15, wherein said pharmaceutical composition is a supplement. 17. A method for producing a beverage comprising a pomegranate juice component and a pomegranate extract component, wherein said beverage is prepared by a process comprising: crushing and squeezing whole fruits of pomegranate including inner and outer peels and seeds to yield a juice component and an insoluble by-product component; separating said juice component from said insoluble by-product component; resuspending said insoluble by-product component in an aqueous medium; mixing said resuspended insoluble by-product component and said aqueous medium; separating an aqueous extract from said insoluble by-product component, wherein said aqueous extract comprises a therapeutically effective amount of polyphenols resulting from said insoluble by-product component; and combining said aqueous extract and said juice component. 18. The method of claim 17, wherein said combining step further comprises measuring a dosage unit of said extract to combine with a serving of said juice component using polyphenols as a measurement marker for said dosage unit. 19. The method of claim 17, wherein said dosage unit comprises at least 30 micromols of said polyphenols. 20. The method of claim 17, wherein said dosage unit comprises at least 3000 micromols of said polyphenols.