초록 ▼

Novel biofunctionalized quantum dots include a mercaptoalkanoic acid linked to the surface of a nanocrystalline core and a bio-functional group linked to the surface. Biofunctionalized quantum dots are made by a novel synthesis method. Biofunctionalized quantum dots can be used in imaging or therapy

Novel biofunctionalized quantum dots include a mercaptoalkanoic acid linked to the surface of a nanocrystalline core and a bio-functional group linked to the surface. Biofunctionalized quantum dots are made by a novel synthesis method. Biofunctionalized quantum dots can be used in imaging or therapy applications.

대표청구항 ▼

What is claimed is: 1. A method for producing a biofunctionalized quantum dot, comprising: refluxing simultaneously a biofunctional group-thiol of Formula III and a mercaptoalkanoic acid, a cadmium salt, a hydrogen-alkali-selenide or hydrogen-alkali-telluride, and a suitable solvent to produce

What is claimed is: 1. A method for producing a biofunctionalized quantum dot, comprising: refluxing simultaneously a biofunctional group-thiol of Formula III and a mercaptoalkanoic acid, a cadmium salt, a hydrogen-alkali-selenide or hydrogen-alkali-telluride, and a suitable solvent to produce a quantum dot in a solution, wherein R1 comprises a hydrocarbon, and wherein the biofunctional group comprises a saccharide. 2. The method of claim 1, wherein the refluxing uses a solvent comprising water or N,N-dimethylformamide. 3. The method of claim 1, wherein the biofunctional group-thiol of Formula III is produced by the steps of: reacting a glycoside of Formula I with an alkylthio acid to produce a thioester of Formula II; debenzylidenating the thioester of Formula II; and hydrolyzing the thioester of Formula II to produce a biofunctional group-thiol of Formula III, wherein R1 comprises a carbon atom and R2 comprises a carbon atom. 4. A method according to claim 1, comprises: providing a biofunctional group-thiol of Formula VI by the steps of: reacting a glycoside of Formula IV with an alkylthio acid in the presence of 2,2′-azobisisobutyronitrile in 1,4-dioxane at about 75° C. to produce a thioester of Formula V; debenzylidinating the thioester of Formula V; hydrolyzing the debenzylidinated thioester of Formula V to produce a Thomsen-Friedenreich-thiol of Formula VI; and refluxing simultaneously the Thomsen-Friedenreich-thiol of Formula VI with cadmium perchlorate. mercaptoacetic acid, hydrogen sodium telluride, and a suitable solvent, selected from the group consisting of water and N,N-dimethylformamide, to produce a Thomsen-Friedenreich-functionalized quantum dot in a solution.