Reaction block for parallel synthetic chemistry and vessel therefor
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01L-003/00
B01L-099/00
B01J-019/00
출원번호
UP-0491447
(2006-07-21)
등록번호
US-7794668
(2010-10-04)
우선권정보
EP-01810859(2001-09-07)
발명자
/ 주소
Bar, Roman
Mueller, Claus
Voegelin, Dieter
출원인 / 주소
Hoffmann-La Roche Inc.
대리인 / 주소
Johnston, George W.
인용정보
피인용 횟수 :
1인용 특허 :
7
초록▼
A reaction vessel for use in an apparatus for parallel synthetic chemistry with a reaction chamber space for containing contents of a chemical reaction and a discharge channel for selectively removing liquid contents of the reaction chamber. The invention includes an apparatus for receiving a plural
A reaction vessel for use in an apparatus for parallel synthetic chemistry with a reaction chamber space for containing contents of a chemical reaction and a discharge channel for selectively removing liquid contents of the reaction chamber. The invention includes an apparatus for receiving a plurality of the reaction vessels, a method for using the apparatus and a method for forming the vessels.
대표청구항▼
What is claimed is: 1. A reaction vessel for performing chemical reactions, comprising: (a) a single-piece body made of a polymeric material, the body defining a reaction chamber, a connection channel, and a discharge channel, each having an interior space; said body having an outer shape that corr
What is claimed is: 1. A reaction vessel for performing chemical reactions, comprising: (a) a single-piece body made of a polymeric material, the body defining a reaction chamber, a connection channel, and a discharge channel, each having an interior space; said body having an outer shape that corresponds to the inner shape of a corresponding cavity of a reaction block, said body being thereby adapted to be inserted into said cavity; (b) the reaction chamber and the discharge channel each having an upper end with an opening therein; (c) the reaction chamber and the discharge channel each having a bottom portion with an orifice therein; (d) the reaction chamber and the discharge channel each tapering from the open upper end toward the bottom portion with decreasing cross-sectional area; and (e) the connection channel extending from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel and thereby fluidically connecting the interior space of the discharge channel with the interior space of the reaction chamber, said connection channel having a circular cross-section which decreases in diameter from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel, wherein the opening at the upper end of the reaction chamber and the opening at the upper end of the discharge channel are interconnected by a channel, hole or groove which fluidically connects the interior of the reaction chamber with the interior of the discharge channel. 2. A reaction vessel according to claim 1, wherein the reaction chamber space has a mean cross-sectional area between about 10 to about 1000 square millimeters. 3. A reaction vessel according to claim 2, wherein the reaction chamber has a mean cross-sectional area in a range between about 75 to about 120 square millimeters. 4. A reaction vessel according to claim 3, wherein the discharge channel has a cross-sectional area between about 0.8 to about 25 square millimeters. 5. A reaction vessel according to claim 2, wherein the vessel has a length between about 20 to about 200 millimeters. 6. A reaction vessel according to claim 1 further comprising filtering means near the bottom portion of the reaction chamber, so that a reaction medium contained within the reaction chamber can be withdrawn from the reaction chamber into the discharge channel through the filtering means. 7. A reaction vessel according to claim 6, wherein said filtering means is a filtration material. 8. A reaction vessel according to claim 6, wherein the filtering means is placed in a seat provided in the wall of the reaction vessel, said seat being located at the level of said orifice of the bottom portion of the reaction chamber. 9. A reaction vessel according to claim 1, wherein the reaction chamber has a longitudinal axis and the discharge channel extends substantially parallel to the longitudinal axis of the reaction chamber. 10. A reaction vessel according to claim 1, wherein said reaction chamber space is defined by a lateral wall having an outside surface and the discharge channel extends either substantially within said lateral wall or along the outside surface of the wall. 11. A reaction vessel according to claim 1, wherein said body is formed from a material selected from the group consisting of polypropylene and a fluorinated polymer. 12. A reaction vessel according to claim 1, wherein the reaction chamber has an upper open end defining an upper rim and the discharge channel has an upper open end located at the upper rim of the reaction vessel, said upper open end of said reaction chamber and said upper open end of said discharge channel being located at said upper rim. 13. An apparatus for conducting at least two chemical reactions in reaction vessels, wherein the apparatus has at least two reaction vessels each of which comprises: (a) a single-piece body made of a polymeric material, the body defining a reaction chamber, a connection channel, and a discharge channel, each having an interior space; said body having an outer shape that corresponds to the inner shape of a corresponding cavity of a reaction block, said body being thereby adapted to be inserted into said cavity; (b) the reaction chamber and the discharge channel each having an upper end with an opening therein; (c) the reaction chamber and the discharge channel each having a bottom portion with an orifice therein; (d) the reaction chamber and the discharge channel each tapering from the open upper end toward the bottom portion with decreasing cross-sectional area; and (e) the connection channel extending from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel and thereby fluidically connecting the interior space of the discharge channel with the interior space of the reaction chamber, said connection channel having a circular cross-section which decreases in diameter from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel, wherein the opening at the upper end of the reaction chamber and the opening at the upper end of the discharge channel are interconnected by a channel, hole or groove which fluidically connects the interior of the reaction chamber with the interior of the discharge channel. 14. The apparatus of claim 13, wherein said apparatus comprises a number of reaction vessels which is an integer multiple of 24. 15. A reactor block for performing a multiplicity of chemical reactions simultaneously, comprising: I. a vessel holder having at least two rows of at least two locations configured and dimensioned to receive a reaction vessel, wherein the reaction vessel comprises: (a) a single-piece body made of a polymeric material, the body defining a reaction chamber a connection channel, and a discharge channel; each having an interior space, said body having an outer shape that corresponds to the inner shape of a corresponding location of said vessel holder, said body being thereby adapted to be inserted into said cavity, (b) the reaction chamber and the discharge channel each having an upper end with an opening therein; (c) the reaction chamber and the discharge channel each having a bottom portion with an orifice therein; (d) the reaction chamber and the discharge channel each tapering from the open upper end toward the bottom portion with decreasing cross-section; and (e) the connection channel extending from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel and thereby fluidically connecting the interior space of the discharge channel with the interior space of the reaction chamber; said connection channel having a circular cross-section which decreases in diameter from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel, wherein the opening at the upper end of the reaction chamber and the opening at the upper end of the discharge channel are interconnected by a channel, hole or groove, which fluidically connects the interior of the reaction chamber with the interior of the discharge channel and II. first closure means having openings, wherein, (a) the first closure means is movable in a sliding manner along a rectilinear path over the openings of the upper ends of the reaction chamber and discharge channel of the reaction vessels when the reaction vessels are received in the locations, and (b) the first closure means is slidable from a first position to a second position so that in the first position when the reaction vessels are received in the locations, the openings in the first closure means allow access to the openings of the upper ends of the reaction chamber and discharge channel of each vessel, and in the second position, the openings of the upper ends of the reaction chamber and discharge channel are closed by the first closure means resting on the open upper ends of the reaction chamber and discharge channel. 16. A reactor block according to claim 15, which further comprises guide means and_wherein the first closure means are each guided in said guide means and the guide means are operably engaged with the first closure means so that the first closure means are sealingly pressed against the openings of the upper ends of the reaction chamber and discharge channel of the reaction vessels, when the first closure means are moved to the second position. 17. A reactor block according to claim 16, wherein the first closure means comprises a slider having pins perpendicular to the sliding direction and openings there through to permit access to the reaction vessels when the first closure means are in the first position, and the guide means comprise at least one pair of gates per reaction vessel location, the gates being arranged substantially adjacent to opposing sides of the respective first closure means so that a pin of the first closure means extends into each gate, so that a first surface part of the gates guide the pins in a plane substantially parallel to the openings of the upper ends of the reaction chamber and discharge channel of the reaction vessels while the first closure means is near to its first position, and a second surface part of the gates guide the pins in a direction inclined to said plane while the first closure means is near to its second position, so that when the first closure means is moved towards its second position, the first closure means is moved towards the openings of the upper ends of the reaction chamber and discharge channel of the reaction vessels for closing them. 18. A reaction vessel for performing chemical reactions, said vessel comprising: (a) a single-piece body made of a polymeric material, shaped by injection molding using a mold and at least one core with a movable attached extension, the body defining a reaction chamber, a connection channel and a discharge channel, each having an interior space said body having an outer shape that corresponds to the inner shape of a corresponding cavity of a reaction block, said body being thereby adapted to be inserted into said cavity; (b) the reaction chamber and the discharge channel each having an upper end with an opening therein; (c) the reaction chamber and the discharge channel each having a bottom portion, with each bottom portion having an orifice therein; (d) the reaction chamber and the discharge channel each tapering from the open upper end towards the bottom portion with decreasing cross-sectional area; (e) the connection channel being formed by the movable, attached extension of the core which is extracted from the connection channel through the reaction chamber or through the discharge channel after injection molding; and (f) the connection channel extending between the orifice of the bottom portion of the reaction chamber orifice and the orifice of the bottom portion of the discharge channel and thereby fluidically connecting the interior space of the discharge channel with the interior space of the reaction chamber, said connection channel having a circular cross-section which decreases in diameter from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel, wherein the opening at the upper end of the reaction chamber and the opening at the upper end of the discharge channel are interconnected by a channel, hole or groove which fluidically connects the interior of the reaction chamber with the interior of the discharge channel. 19. A reaction vessel according to claim 18, wherein the reaction chamber space has a mean cross-sectional area between about 10 to about 1000 square millimeters. 20. A reaction vessel according to claim 19, wherein the reaction chamber has a mean cross-sectional area in a range between about 75 to about 120 square millimeters. 21. A reaction vessel according to claim 20, wherein the discharge channel has a cross-sectional area between about 0.8 to about 25 square millimeters. 22. A reaction vessel according to claim 19, wherein the vessel has a length between about 20 to about 200 millimeters. 23. A reaction vessel according to claim 18, further comprising filtering means near the bottom portion of the reaction chamber, so that a reaction medium contained within the reaction chamber can be withdrawn from the reaction chamber into the discharge channel through the filtering means. 24. A reaction vessel according to claim 23, wherein said filtering means is a filtration material. 25. A reaction vessel according to claim 23, wherein the filtering means is placed in a seat provided in the wall of the reaction vessel, said seat being located at the level of said orifice of the bottom portion of the reaction chamber. 26. A reaction vessel according to claim 18, wherein the reaction chamber has a longitudinal axis and the discharge channel extends substantially parallel to the longitudinal axis of the reaction chamber. 27. A reaction vessel according to claim 18, wherein said reaction chamber space is defined by a lateral wall having an outside surface and the discharge channel extends either substantially within said lateral wall or along the outside surface of the wall. 28. A reaction vessel according to claim 18, wherein said body is formed from a material selected from the group consisting of polypropylene and a fluorinated polymer. 29. A reaction vessel according to claim 18, wherein the reaction chamber has an upper open end defining an upper rim and the discharge channel has an upper open end located at the upper rim of the reaction vessel, said upper open end of said reaction chamber and said upper open end of said discharge channel being located at said upper rim. 30. An apparatus for conducting at least two chemical reactions in reaction vessels, wherein the apparatus has at least two reaction vessels, each reaction vessel comprising: (a) a single-piece body made of a polymeric material, shaped by injection molding using a mold and at least one core with a movable attached extension, the body defining a reaction chamber, a connection channel and a discharge channel, each having an interior space said body having an outer shape that corresponds to the inner shape of a corresponding cavity of a reaction block, said body being thereby adapted to be inserted into said cavity; (b) the reaction chamber and the discharge channel each having an upper end with an opening therein; (c) the reaction chamber and the discharge channel each having a bottom portion, with each bottom portion having an orifice therein; (d) the reaction chamber and the discharge channel each tapering from the open upper end towards the bottom portion with decreasing cross-sectional area; (e) the connection channel being formed by the movable, attached extension of the core which is extracted from the connection channel through the reaction chamber or through the discharge channel after injection molding; and (f) the connection channel extending between the orifice of the bottom portion of the reaction chamber orifice and the orifice of the bottom portion of the discharge channel and thereby fluidically connecting the interior space of the discharge channel with the interior space of the reaction chamber, said connection channel having a circular cross-section which decreases in diameter from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel, wherein the opening at the upper end of the reaction chamber and the opening at the upper end of the discharge channel are interconnected by a channel, hole or groove which fluidically connects the interior of the reaction chamber with the interior of the discharge channel. 31. The apparatus of claim 30, wherein said apparatus comprises a number of reaction vessels which is an integer multiple of 24. 32. A reactor block for performing a multiplicity of chemical reactions simultaneously comprising: I. a vessel holder having at least two rows of at least two locations configured and dimensioned to receive a reaction vessel, wherein the reaction vessel is able to be placed into said location and comprises: (a) a single-piece body made of a polymeric material, shaped by injection molding using a mold and at least one core with a movable attached extension, the body defining a reaction chamber having an interior space, a connection channel and a discharge channel said body having an outer shape that corresponds to the inner shape of a corresponding cavity of a reaction block, said body being thereby adapted to be inserted into said cavity; (b) the reaction chamber and the discharge channel each having an upper end with an opening therein; (c) the reaction chamber and the discharge channel each having a bottom portion, with each bottom portion having an orifice therein; (d) the reaction chamber and the discharge channel each tapering from the open upper end towards the bottom portion with decreasing cross-section; (e) the connection channel being formed by the movable, attached extension of the core which is extracted from the connection channel through the reaction chamber or through the discharge channel after injection molding; and (f) the connection channel extending between the orifice of the bottom portion of the reaction chamber orifice and the orifice of the bottom portion of the discharge channel and thereby fluidically connecting the interior space of the discharge channel with the interior space of the reaction chamber; said connection channel having a circular cross-section which decreases in diameter from the orifice of the bottom portion of the reaction chamber to the orifice of the bottom portion of the discharge channel, wherein the opening at the upper end of the reaction chamber and the opening at the upper end of the discharge channel are interconnected by a channel, hole or groove which fluidically connects the interior of the reaction chamber with the interior of the discharge channel, and II. first closure means having openings, wherein, (a) the first closure means is movable in a sliding manner along a rectilinear path over the openings of the upper ends of the reaction chamber and discharge channel of the reaction vessels when the reaction vessels are received in the locations, and (b) the first closure means is slidable from a first position to a second position so that in the first position when the reaction vessels are received in the locations, the openings in the first closure means allow access to the openings of the upper ends of the reaction chamber and discharge channel of each vessel, and in the second position, the openings of the upper ends of the reaction chamber and discharge channel are closed by the first closure means resting on the open upper ends of the reaction chamber and discharge channel. 33. A reactor block according to claim 32, which further comprises guide means and_wherein the first closure means are each guided in said guide means and the guide means are operably engaged with the first closure means so that the first closure means are sealingly pressed against the openings of the upper ends of the reaction chamber and discharge channel of the reaction vessels, when the closure means are moved to the second position. 34. A reactor block according to claim 33, wherein the first closure means comprises a slider having pins perpendicular to the sliding direction and openings therethrough to permit access to the reaction vessels when the first closure means are in the first position, and the guide means comprise at least one pair of gates per reaction vessel location, the gates being arranged substantially adjacent to opposing sides of the respective first closure means so that a pin of the first closure means extends into each gate, so that a first surface part of the gates guide the pins in a plane substantially parallel to the openings of the upper ends of the reaction chamber and discharge channel of the reaction vessels while the first closure means is near to its first position, and a second surface part of the gates guide the pins in a direction inclined to said plane while the first closure means is near to its second position, so that when the first closure means is moved towards its second position, the first closure means is moved towards the openings of the upper ends of the reaction chamber and discharge channel of the reaction vessels for closing them.
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