IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0928927
(2007-10-30)
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등록번호 |
US-7799888
(2010-10-11)
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발명자
/ 주소 |
- Arkles, Barry C.
- Kimble, Edward
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출원인 / 주소 |
|
대리인 / 주소 |
Panitch Schwarze Belisario & Nadel LLP
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인용정보 |
피인용 횟수 :
2 인용 특허 :
17 |
초록
▼
Low molecular weight siloxane materials having one functional group are provided which have reduced tendency to form phase separated domains after polymerization. Two classes of siloxane materials are included: (1) symmetric siloxane macromonomers containing at least two monomer termini and one poly
Low molecular weight siloxane materials having one functional group are provided which have reduced tendency to form phase separated domains after polymerization. Two classes of siloxane materials are included: (1) symmetric siloxane macromonomers containing at least two monomer termini and one polymerizable functional group which is equidistant from the termini, and (2) assymetric siloxane macromonomers having at least one polymerizable functional group terminus and at least one oxygen-containing polar hydrophilic terminus selected from the group consisting of hydroxyl, ether, and polyether. Symmetric siloxane macromonomers having hydroxyl termini are useful for forming biocompatible materials, such as for contact lenses, tissue regeneration scaffold polymers, and coatings to reduce non-specific binding of proteins.
대표청구항
▼
We claim: 1. A symmetric siloxane macromonomer comprising a low molecular weight siloxane polymer having two or three monomer termini and one polymerizable functional group, wherein the polymerizable functional group is located equidistant from each of the two or three monomer termini and wherein t
We claim: 1. A symmetric siloxane macromonomer comprising a low molecular weight siloxane polymer having two or three monomer termini and one polymerizable functional group, wherein the polymerizable functional group is located equidistant from each of the two or three monomer termini and wherein the two or three monomer termini are polar and hydrophilic. 2. The symmetric siloxane macromonomer according to claim 1, wherein the polymerizable functional group is selected from the group consisting of vinyl, methacryloxyalkyl, acryloxyalkyl, arylamidoalkyl, and styryl. 3. The symmetric siloxane macromonomer according to claim 1, wherein the polar and hydrophilic termini comprise groups selected from the group consisting of hydroxyl, ether, and polyether groups. 4. The symmetric silxoane macromonomer according to claim 1, wherein the siloxane polymer has a molecular weight of less than about 20,000 Daltons. 5. The symmetric siloxane macromonomer according to claim 1, wherein the siloxane polymer has a molecular weight of less than about 10,000 Daltons. 6. The symmetric siloxane macromonomer according to claim 1, wherein the siloxane polymer has a molecular weight of about 500 to about 5,000 Daltons. 7. The symmetric siloxane macromonomer according to claim 1, wherein the siloxane macromonomer comprises a substituted or unsubstituted polyalkylmethylsiloxane backbone. 8. The symmetric siloxane macromonomer according to claim 1, wherein the siloxane macromonomer comprises a polydimethylsiloxane backbone. 9. The symmetric siloxane macromonomer according to claim 1, wherein the siloxane macromonomer comprises a backbone selected from the group consisting of a fluorinated polyalkylmethylsiloxane backbone, a polydiphenylsiloxane backbone, and a polyphenylmethylsiloxane backbone. 10. The symmetric siloxane macromonomer according to claim 1, wherein the siloxane macromonomer comprises a backbone comprising at least two different blocks. 11. A biocompatible material comprising the macromonomer according to claim 1, wherein the two or three monomer termini comprise hydroxyl groups. 12. The material according to claim 11, wherein the macromonomer has structure (V) wherein n is the degree of polymerization. 13. The symmetric siloxane macromonomer according to claim 1, wherein the macromonomer comprises three monomer termini. 14. A symmetric siloxane macromonomer comprising a low molecular weight siloxane polymer having two or three monomer termini and one polymerizable functional group, wherein the polymerizable functional group is located equidistant from the two or three monomer termini, and wherein the two or three monomer termini are non-polar and hydrophobic and comprise functional groups selected from the group consisting of alkyl and aryl groups with the proviso that, where the functional groups are alkyl groups, at least one of them must be other than a methyl group. 15. The symmetric siloxane macromonomer according to claim 14, wherein the polymerizable functional group is selected from the group consisting of vinyl, methacryloxyalkyl, acryloxyalkyl, arylamidoalkyl, and styryl. 16. The symmetric silxoane macromonomer according to claim 14, wherein the siloxane polymer has a molecular weight of less than about 20,000 Daltons. 17. The symmetric siloxane macromonomer according to claim 14, wherein the siloxane polymer has a molecular weight of less than about 10,000 Daltons. 18. The symmetric siloxane macromonomer according to claim 14, wherein the siloxane polymer has a molecular weight of about 500 to about 5,000 Daltons. 19. The symmetric siloxane macromonomer according to claim 14, wherein the siloxane macromonomer comprises a substituted or unsubstituted polyalkylmethylsiloxane backbone. 20. The symmetric siloxane macromonomer according to claim 14, wherein the siloxane macromonomer comprises a polydimethylsiloxane backbone. 21. The symmetric siloxane macromonomer according to claim 14, wherein the siloxane macromonomer comprises a backbone selected from the group consisting of a fluorinated polyalkylmethylsiloxane backbone, a polydiphenylsiloxane backbone, and a polyphenylmethylsiloxane backbone. 22. The symmetric siloxane macromonomer according to claim 14, wherein the siloxane macromonomer comprises a backbone comprising at least two different blocks. 23. The symmetric siloxane macromonomer according to claim 14, wherein the siloxane polymer comprises three monomer termini. 24. The symmetric siloxane macromonomer according to claim 23, wherein the macromonomer has structure (II): wherein n is the degree of polymerization.
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