A drug transfer system is adapted to transfer a powdered drug into a patient via inhalation. The drug transfer system includes a drug container or packet that removably inserts into an inhaler device. As the patient inhales from the inhaler device, the drug flows from the container, through the inha
A drug transfer system is adapted to transfer a powdered drug into a patient via inhalation. The drug transfer system includes a drug container or packet that removably inserts into an inhaler device. As the patient inhales from the inhaler device, the drug flows from the container, through the inhaler device, and into the patient's respiratory system. The system is adapted for ease of use without requiring the user to perform any cumbersome manipulations of the drug packet during insertion into the inhaler or during inhalation of the drug.
대표청구항▼
What is claimed is: 1. A drug dispenser package, comprising: a blister containing a powder formed of a plurality of particles, the blister including: (a) a vertex; (b) a first limb extending outwardly from the vertex, wherein an air entry port is positioned at an end of the first limb opposite the
What is claimed is: 1. A drug dispenser package, comprising: a blister containing a powder formed of a plurality of particles, the blister including: (a) a vertex; (b) a first limb extending outwardly from the vertex, wherein an air entry port is positioned at an end of the first limb opposite the vertex, the air entry port providing an entryway for air to flow into the blister; (c) a second limb extending outwardly from the vertex, wherein an air exit port is positioned at an end of the second limb opposite the vertex, the air exit port providing an exitway for air to flow out of the blister with at least a portion of the powdered drug; an aspiration hole separate from the air entry port and air exit port, the aspiration hole having a size that is less than the minimum size of all the particles of the powder such that the aspiration hole is sufficiently large to permit airflow into the blister but too small to permit a particle of the powder to pass through the aspiration hole; and wherein the blister comprises side walls that extend outwardly from a base at an angle of 90 degrees relative to the base an inhaler that removably docks with the blister, the inhaler adapted to transfer drug from the blister into a patient upon inhalation of the patient from the inhaler, the inhaler including a mouthpiece that inserts into the patient's mouth, a cap removably attached to the mouthpiece and sized and shaped to provide a storage space for the blister, and a blister interface that is removably attached to the mouthpiece and the cap and adapted to receive the blister in a manner that positions the blister in the inhaler in a proper orientation for use, wherein the blister interface includes an airflow hole that aligns with the air exit port of the second limb when the blister is positioned in the blister interface. 2. A package as in claim 1, wherein the vertex has a radius of curvature. 3. A package as in claim 2, wherein the radius of curvature is approximately 0.200 inch. 4. A package as in claim 1, wherein at least one of the air entry port or air exit port is a single hole. 5. A package as in claim 4, wherein the single hole has a diameter in the range of 0.040 inch to 0.080 inch. 6. A package as in claim 1, wherein at least one of the air entry port or air exit port is a plurality of holes, each hole having a diameter of no more than about 0.050 inch. 7. A package as in claim 1, wherein at least one of the air entry port or air exit port is at least one hole having a diameter in the range of about 0.010 inch to about 0.080 inch. 8. A package as in claim 1, wherein at least one of the air entry port or air exit port is a plurality of small holes each having a diameter of about 0.020 inch. 9. A package as in claim 1, further comprising a guide member that interacts with an inhaler to assist in properly guiding the package into a proper docked position during insertion of the package into the inhaler, and wherein the guide member comprises a semicircular cut-out that extends into an edge of the blister. 10. A package as in claim 1, wherein the package generally includes a blister lid attached to the blister and a removable lid attached to the blister lid, the removable lid covering the air entry port and air exit port. 11. A package as in claim 1, wherein the blister is at least partially transparent. 12. A package as in claim 1, wherein the blister has a top wall and a base, the top wall spaced a distance of about 0.020 inch to about 0.400 inch from the base. 13. A package as in claim 12, wherein the distance between the top wall and the base varies at different locations of the blister. 14. A package as in claim 1, wherein the limbs are symmetric relative to a midline that extends through the vertex. 15. A package as in claim 1, wherein the vertex is shaped to facilitate placement of the powdered drug in a single location in the blister. 16. A package as in claim 15, wherein the volume of the vertex of the blister is such that there is empty space above the powdered drug when all of the powdered drug is positioned in the vertex. 17. A package as in claim 1, wherein the cross-sectional area of the blister at the vertex is less than the cross-sectional area at the locations of the ports. 18. A package as in claim 1, wherein the blister tapers in size moving toward at least one of the air entry port and the air exit port. 19. A drug transfer system, comprising: (1) a blister containing a powder formed of a plurality of particles, the blister including: (a) a vertex; (b) a first limb extending outwardly from the vertex, wherein an air entry port is positioned at an end of the first limb opposite the vertex, the first air entry port providing an entryway for air to flow into the blister; (c) a second limb extending outwardly from the vertex, wherein an air exit port is positioned at an end of the second limb opposite the vertex, the air exit port providing an exitway for air to flow out of the blister with at least a portion of the powdered drug; (d) an aspiration hole separate from the air entry port and air exit port, the aspiration hole having a size that is less than the minimum size of all the particles of the powder such that the aspiration hole is sufficiently large to permit airflow into the blister but too small to permit a particle of the powder to pass through the aspiration hole, and wherein the blister comprises side walls that extend outwardly from a base at an angle of 90 degrees relative to the base; and (2) an inhaler that removably docks with the blister, the inhaler adapted to transfer drug from the blister into a patient upon inhalation of the patient from the inhaler, the inhaler adapted to transfer drug from the blister into a patient upon inhalation of the patient from the inhaler, the inhaler including a mouthpiece that inserts into the patient's mouth, a cap removably attached to the mouthpiece and sized and shaped to provide a storage space for the blister, and a blister interface that is removably attached to the mouthpiece and the cap and adapted to receive the blister in a manner that positions the blister in the inhaler in a proper orientation for use, wherein the blister interface includes an airflow hole that aligns with the air exit port of the second limb when the blister is positioned in the blister interface. 20. A drug transfer system as in claim 19, wherein the inhaler includes a spiral disaggregation chamber. 21. A drug transfer system as in claim 19, wherein the blister has blister guide member having a shape that mates with a correspondingly-shaped inhaler guide member in the inhaler when the blister is properly docked into the inhaler. 22. A drug transfer system as in claim 19, wherein the blister guide member is a cut-out and the inhaler guide member is a protrusion. 23. A drug transfer system as in claim 19, wherein gravity concentrates drug in the vertex of the blister when the blister is docked in the inhaler. 24. A drug transfer system as in claim 19, wherein the air entry port is positioned outside of the inhaler and the air exit port is positioned inside the inhaler when the blister is docked in the inhaler. 25. A drug transfer system as in claim 19, wherein the inhaler has a flow resistance in response to patient inhalation, the flow resistance being in the range of about approximately 0.020 to approximately 0.400 (centimeter H2O0.5)/Liter/minute. 26. A drug transfer system as in claim 1 or 19, wherein at least one of the first limb and second limb is oriented relative to the vertex at an angle that is sufficiently steep to induce powder within the limb to slide into the vertex by the force of gravity.
Burr John D. ; Smith Adrian E. ; Hall Randy K. ; Snyder Herman ; Schuler Carlos ; Axford George S. ; Ray Charles, Dry powder dispersing apparatus and methods for their use.
Eisele Robert F. (Laguna Niguel CA) Cameron Allan (Santa Monica CA) Titzler David (Newbury Park CA) Porche Leonard (Simi Valley CA), Dry powder inhaler delivery system.
Ambrosio Thomas J. ; Benson ; Jr. Warren A. ; Dao Kim C. ; Kenyon David J. ; Kreiseder Walter J. ; Schonebaum Theodore J. ; Vogel Allen J. ; Walker Louis B. ; Yang Tsong-Toh, Powdered medication inhaler.
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