초록 ▼

A biologically-active article includes a substrate having a substrate surface and a silver releasing chromonic material disposed adjacent to the substrate surface. The silver releasing chromonic material includes a chromonic compound and a silver ion source. Methods of forming the same are also disc

A biologically-active article includes a substrate having a substrate surface and a silver releasing chromonic material disposed adjacent to the substrate surface. The silver releasing chromonic material includes a chromonic compound and a silver ion source. Methods of forming the same are also disclosed.

대표청구항 ▼

What is claimed is: 1. A wound dressing comprising a biologically-active article, the biologically-active article comprising a substrate having a substrate surface, and a silver ion releasing chromonic material disposed adjacent to the substrate surface, wherein the silver ion releasing chromonic m

What is claimed is: 1. A wound dressing comprising a biologically-active article, the biologically-active article comprising a substrate having a substrate surface, and a silver ion releasing chromonic material disposed adjacent to the substrate surface, wherein the silver ion releasing chromonic material comprising a chromonic compound and a silver ion source, wherein the silver ion source is an antimicrobial agent, wherein the release of silver ions from the silver ion source is moisture activated, and wherein the silver ion releasing chromonic materials is represented at least one of the following general structures: wherein for structure I, each R2 is independently selected from the group consisting of electron donating groups, electron withdrawing groups, and electron neutral groups; R3 is selected from the group consisting of substituted and unsubstituted heteroaromatic rings and substituted and unsubstituted heterocyclic rings, these rings being linked to the triazine group through a nitrogen atom within the ring of R3, and M+ is a silver metal cation; wherein for structure II, each R2 is independently selected from the group consisting of electron donating groups, electron withdrawing groups, and electron neutral groups; R3 is selected from the group consisting of substituted and unsubstituted heteroaromatic rings and substituted and unsubstituted heterocyclic rings, these rings being linked to the triazine group through a nitrogen atom within the ring of R3; and M+ is a silver metal cation; wherein for structure III, M+ is a silver metal cation; and X− is a counterion; and wherein for structure IV, M+ is a silver metal cation. 2. The wound dressing according to claim 1, wherein in structure (III), X− is selected from the group consisting of HSO4−, Cl−, CH3COO−, and CF3COO−. 3. The wound dressing according to claim 1 wherein the silver ion releasing chromonic material forms indicia. 4. The wound dressing according to claim 1 wherein the silver ion releasing chromonic material is in the form of a pattern. 5. The wound dressing according to claim 4 wherein the pattern of silver ion releasing chromonic material is a printed pattern on the surface of the article. 6. The wound dressing according to claim 1 wherein the silver ion source has a mean diameter in a range from 1 to 500 nanometers. 7. The wound dressing according to claim 1 wherein the chromonic compound has a chromonic structure that encapsulates the silver ion source and provides controlled release of silver ions from the chromonic structure. 8. The wound dressing according to claim 1 wherein the chromonic compound has a chromonic structure that forms cavities, and the silver ion source is disposed in the cavities. 9. The wound dressing according to claim 1 wherein the chromonic compound exhibits a self-assembling stacking structure of chromonic molecules that form cavities, and the silver ion source is intercalated into the cavities. 10. The wound dressing according to claim 1 wherein the release of silver ions from the silver ion source is a time dependent controlled release of silver ions. 11. A wound dressing according to claim 1 wherein the release of silver ions from the silver ion source is sustainable over time so as to provide antimicrobial activity suitable for the treatment of chronic wounds. 12. The wound dressing according to claim 1 wherein the silver ion releasing chromonic material exhibits a visible coloration that fades as silver ions are released from the silver ion source. 13. The wound dressing according to claim 12 wherein the visible coloration of the silver ion releasing chromonic material fades such that a user is able to determine when the silver ions are no longer being released.