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A thermally-reactive polymer that forms a polymer-coupled reactive species upon heating is described and useful for forming coated surfaces. The polymer-coated surface has improved lubricity and passivity. A thermally-reactive quaternary amine-containing polymer was produced that provides passivity

A thermally-reactive polymer that forms a polymer-coupled reactive species upon heating is described and useful for forming coated surfaces. The polymer-coated surface has improved lubricity and passivity. A thermally-reactive quaternary amine-containing polymer was produced that provides passivity and anti-microbial activity.

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What is claimed is: 1. A method for forming a coating comprising steps of: a) providing a polymer comprising i) a backbone comprising thermally-stable linkages and ii) a thermally-reactive group pendent from the backbone; b) disposing the polymer on all or a portion of a surface of an article; and

What is claimed is: 1. A method for forming a coating comprising steps of: a) providing a polymer comprising i) a backbone comprising thermally-stable linkages and ii) a thermally-reactive group pendent from the backbone; b) disposing the polymer on all or a portion of a surface of an article; and c) heating the polymer, wherein thermally-reactive group homolytically cleaves upon heating resulting in the generation of radical species comprising a second radical species and a polymer-coupled radical species, wherein the second radical species is more reactive than the polymer-coupled radical species, and wherein the polymer-coupled radical species that forms covalent bonds with a target moiety and becomes associated with the surface of the article, thereby forming the coating. 2. The method of claim 1 wherein the thermally-reactive group comprises a peroxide group. 3. The method of claim 2 wherein the thermally-reactive group comprises a peroxyester group. 4. The method of claim 1 wherein the polymer coupled radical species comprises an (alkyldioxyl) radical species, wherein X1 is a portion of the polymeric backbone of the polymer, and X2 is selected from the group consisting of alkyl, benzyl, diphenylacetyl, phenylacetyl, benzoyl, phenylbenzyl, hydrocinnamoyl, mandelyl, phenacyl, phenethyl, thiophenacyl, triphenylmethyl, biphenylacetyl, biphenylethyl, biphenylmethyl, allyl, and substituted allyl. 5. The method of claim 1 wherein the thermally-reactive group has a decomposition temperature of 110° C. or less. 6. The method of claim 1 which provides the formation of a hydrophilic coating. 7. The method of claim 1 wherein the backbone is selected from the group consisting of polyester, polycarbonate, polyamide, polyether, polysulfone, polyurethane, and polyimide backbones. 8. The method of claim 1 wherein the backbone is formed from monomeric units having ethylenically unsaturated groups. 9. The method of claim 1 wherein the backbone comprises (meth)acrylamide, acrylamide, or vinylpyrrolidone monomeric units. 10. The method of claim 9 wherein the backbone comprises acrylamide. 11. The method of claim 1 wherein the polymer has a molecular weight of 1000 Da or greater. 12. The method of claim 11 wherein the polymer has a molecular weight of 5000 Da or greater. 13. The method of claim 1 wherein the polymer comprises 10 molar percent or more thermally-reactive groups. 14. The method of claim 1 wherein the polymer further comprises pendent quaternary amine groups. 15. The method of claim 14 wherein the polymer comprises 10 molar percent or more pendent quaternary amine groups. 16. The method of claim 1, wherein the polymer does not include an ethylenically unsaturated group. 17. The method of claim 1 wherein (c) the polymer becomes covalently bonded to the surface. 18. The method of claim 1 wherein step (b) the polymer is disposed on an article comprising one or more additional coated layer(s). 19. The method of claim 18 wherein step (c) the polymer becomes covalently bonded to a second polymer present in the one or more additional coated layer(s). 20. The method of claim 19 wherein the second polymer comprises poly(vinyl)pyrrolidone. 21. The method of claim 1 wherein the article comprises a complex geometry. 22. The method of claim 1 wherein step (b), step (c), or both steps (b) and (c), further includes drying the polymer on the surface of the substrate. 23. The method of claim 1 wherein heating is performed at a temperature of not more than 200° C. 24. The method of claim 23 wherein heating is performed at a temperature in the range of 40° C. to 80° C. 25. The method of claim 1 wherein the polymer is disposed on the article at a concentration of 0.5 mg/ml or greater. 26. The method of claim 1 wherein the backbone is selected from polyvinyl polymers. 27. The method of claim 26 wherein the backbone is selected from the group consisting of poly(meth)acrylamides, polyacrylamides, and poly(vinylpyrrolidone). 28. The method of claim 1 wherein the article comprises an inner surface and in step (b) the polymer is disposed on the inner surface of the article. 29. The method of claim 28 wherein the article is selected from the group of consisting of stents and catheters. 30. A method for coating an article comprising steps of: a) providing a polymer comprising i) a backbone comprising thermally-stable linkages and ii) a thermally-reactive group pendent from the backbone comprising a pair of atoms with a heat sensitive labile bond selected from the group consisting of oxygen-oxygen, nitrogen-oxygen, and nitrogen-nitrogen; b) disposing the polymer on all or a portion of a surface of the article; and c) heating the polymer, wherein thermally-reactive grow homolytically cleaves upon heating resulting in the generation of radical species comprising a second radical species and a polymer-coupled radical species, wherein the second radical species is more reactive than the polymer-coupled radical species, and wherein the polymer-coupled radical species that forms covalent bonds with a target moiety and becomes associated with the surface of the article, thereby forming the coating. 31. A method for coating an article comprising steps of a) providing a polymer comprising i) a backbone comprising thermally-stable linkages and ii) a thermally-reactive peroxyester group pendent from the backbone; b) disposing the polymer on all or a portion of a surface of the article; and c) heating the polymer, wherein thermally-reactive group homolytically cleaves upon heating resulting in the generation of radical species comprising a second radical species and a polymer-coupled radical species, wherein the second radical species is more reactive than the polymer-coupled radical species, and wherein the polymer-coupled radical species that forms covalent bonds with a target moiety and becomes associated with the surface of the article, thereby forming the coating. 32. A method for coating an inner surface of a medical article comprising steps of: a) providing a polymer comprising i) a backbone comprising thermally-stable linkages and ii) a thermally-reactive group pendent from the backbone; b) disposing the polymer on all or a portion of the inner surface of the medical article; and c) heating the polymer, wherein thermally-reactive group homolytically cleaves upon heating resulting in the generation of radical species comprising a second radical species and a polymer-coupled radical species, wherein the second radical species is more reactive than the polymer-coupled radical species, and wherein the to form a polymer-coupled radical species forms covalent bonds with a target moiety and becomes associated with the inner surface of the article, thereby forming the coating. 33. The method of claim 1 wherein the polymer coupled radical species comprises an alkyl group pendent from the backbone of the polymer. 34. The method of claim 1 wherein the polymer coupled radical species comprises a chemical group selected from the group consisting of benzyl, diphenylacetyl, phenylacetyl, benzoyl, phenylbenzyl, hydrocinnamoyl, mandelyl, phenacyl, phenethyl, thiophenacyl, triphenylmethyl, biphenylacetal, biphenylethyl, biphenylmethyl, allyl, substituted allyl, and carboxyl, wherein the chemical group is pendent from the backbone of the polymer. 35. The method of claim 1, wherein step (b) the polymer is present in a coating composition at a concentration of 0.5 mg/mL or greater, and the coating composition is disposed on the on all or a portion of the surface of the article. 36. The method of claim 35, wherein the polymer is present in the coating composition at a concentration in the range of 0.5 mg/mL to 10 mg/mL. 37. The method of claim 1 wherein the second radical species comprises an .OR (alkoxy) radical species. 38. The method of claim 1, wherein the polymer is formed by a process comprising nucleophilic reaction of a pre-polymer comprising thermally stable linkages with a compound comprising a thermally-reactive group. 39. The method of claim 38 wherein the process comprising nucleophilic reaction, the compound comprising a thermally-reactive group further comprises a halogen atom. 40. The method of claim 38 wherein the process comprising nucleophilic reaction, the pre-polymer comprises thermally stable linkages and a pendent amine group. 41. The method of claim 38 wherein the nucleophilic reaction comprises iodo-amine coupling.