[특허]Medical devices for delivering a therapeutic agent and method of preparation

[미국특허] Medical devices for delivering a therapeutic agent and method of preparation 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-002/06
출원번호	UP-0929785 (2007-10-30)
등록번호	US-7811317 (2010-11-01)
발명자 / 주소	Berg, Eric P. Tuch, Ronald J. Dror, Michael Wolff, Rodney G.
출원인 / 주소	Medtronic, Inc.
인용정보	피인용 횟수 : 0 인용 특허 : 119

초록 ▼

A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.

대표청구항 ▼

What is claimed is: 1. A method for delivery of a therapeutic substance to the interior of a body lumen using a radially expandable intravascular stent, the stent being made by applying to the stent a mixture of a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent, evaporating the solvent to provide a coat of therapeutic substance and polymer on the stent, and repeating the applying and evaporating until a plurality of coats of therapeutic substance and polymer are on the stent, said method for delivery comprising the steps of: introducing the stent and the plurality of coats of therapeutic substance and polymer transluminally into a selected portion of the body lumen; and radially expanding the stent and the plurality of coats of therapeutic substance and polymer into contact with the body lumen such that the plurality of coats of therapeutic substance and polymer are retained on the stent, wherein the ratio of therapeutic substance to polymer in the mixture is in the range of about 10:1 to 1:100. 2. The method according to claim 1, wherein the stent has a metal surface. 3. The method according to claim 1, wherein the mixture is applied to the stent by spraying. 4. A method for delivery of a therapeutic substance to the interior of a body lumen, comprising the steps of: introducing a stent having a plurality of coats of therapeutic substance and polymer on a surface thereof transluminally into a selected portion of the body lumen; and radially expanding the stent and the plurality of coats of therapeutic substance and polymer into contact with the body lumen such that the plurality of coats of therapeutic substance and polymer are retained on the surface, wherein the stent is made by the process of: (a) providing a generally cylindrical, balloon expandable metal stent body having a surface; (b) spraying onto the stent body a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent; (c) evaporating the solvent to provide a coat of therapeutic substance and polymer on the surface; and (d) repeating steps (b) and (c) until a plurality of coats of therapeutic substance and polymer are on the surface, wherein the ratio of therapeutic substance to polymer in the mixture is in the range of about 10:1 to 1:100.

이 특허에 인용된 특허 (119) 인용/피인용 타임라인 분석

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저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
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안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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[미국특허] Medical devices for delivering a therapeutic agent and method of preparation 원문보기

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