Tissue repair compositions and methods for their manufacture and use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-035/32
A61K-038/18
출원번호
UP-0459972
(2006-07-26)
등록번호
US-7811608
(2010-11-01)
발명자
/ 주소
Kay, John F.
Borden, Mark
Coulson, Richard
King, Edward
출원인 / 주소
Isotis Orthobiologics, Inc.
인용정보
피인용 횟수 :
17인용 특허 :
34
초록▼
An osteogenic composition is prepared by a process including the steps of subjecting demineralized bone to an extraction medium to produce an insoluble extraction product and a soluble extraction product, separating the insoluble extraction product and the soluble extraction product, drying the solu
An osteogenic composition is prepared by a process including the steps of subjecting demineralized bone to an extraction medium to produce an insoluble extraction product and a soluble extraction product, separating the insoluble extraction product and the soluble extraction product, drying the soluble extraction product to remove all or substantially all of the moisture in the soluble extracting product, and combining the dried soluble extraction product with demineralized bone particles. Preferably, the process does not involve heating.
대표청구항▼
What is claimed is: 1. An osteogenic composition comprising: demineralized bone particles enriched with dried, acid-soluble, demineralized bone extraction product derived from demineralized bone contacted with an acidic extraction medium at a pH of between 0.5 and 5.5 and at an extraction temperatu
What is claimed is: 1. An osteogenic composition comprising: demineralized bone particles enriched with dried, acid-soluble, demineralized bone extraction product derived from demineralized bone contacted with an acidic extraction medium at a pH of between 0.5 and 5.5 and at an extraction temperature between about 15° C. and 25° C.; and a thickening material selected from the group consisting of collagen, insoluble extraction product, calcium phosphate, hydroxyapatite, tricalcium phosphate, biphasic calcium phosphate, calcium sulfate, biological glass, natural polymer, synthetic polymer, poloxamer, and reverse phase medium. 2. The osteogenic composition of claim 1, further comprising a bone morphogenetic protein. 3. The osteogenic composition of claim 1, further comprising an active ingredient selected from the group consisting of bone morphogenetic protein, cartilage derived morphogenetic protein, cortical bone, cancellous bone, bone mineral, osteogenic chemical, osteogenic peptide, osteogenic growth factor, recombinant bone morphogenetic protein, fibronectin, blood, bone marrow and blood-derived protein. 4. The composition of claim 1, wherein said dried, acid-soluble, demineralized bone extraction product is a white, fluffy substance. 5. The composition of claim 1, wherein said dried, acid-soluble, demineralized bone extraction product is further combined with ethanol or water, and an active ingredient selected from the group consisting of bone morphogenetic protein, cartilage derived morphogenetic protein, cortical bone, cancellous bone, bone mineral, osteogenic chemical, osteogenic peptide, osteogenic growth factor, recombinant bone morphogenetic protein, fibronectin, blood, bone marrow and blood-derived protein. 6. The composition of claim 5, wherein the product is further dried after combining with said ethanol or water and said active ingredient. 7. The composition of claim 6, wherein said product is dried by lyophilization. 8. The composition of claim 1, wherein the form of said composition is selected from the group consisting of gel, paste, putty and sponge. 9. An osteogenic composition comprising a dried, acid-soluble extraction product derived from demineralized bone contacted with extraction medium at a pH of between 0.5 and 5.5 and at an extraction temperature between about 15° C. and 25° C. and further including a reverse phase medium. 10. An osteogenic composition comprising a dried, acid-soluble extraction product derived from demineralized bone contacted with extraction medium at a pH of between 0.5 and 5.5 and at an extraction temperature between about 15° C. and 25° C. 11. An osteogenic composition comprising a dried, acid-soluble extraction product derived from demineralized bone contacted with extraction medium at a pH of between 0.5 and 5.5 and at an extraction temperature between about 15° C. and 25° C. and further including demineralized bone particles. 12. The osteogenic composition of claim 9 further including demineralized bone. 13. The osteogenic composition of claim 9 further including cancellous bone. 14. The osteogenic composition of claim 9 further including bone marrow. 15. The osteogenic composition of claim 10 further including cancellous bone. 16. The osteogenic composition of claim 10 further including bone marrow. 17. An osteogenic composition comprising: demineralized bone particles enriched with dried, acid-soluble, demineralized bone extraction product derived from demineralized bone contacted with extraction medium at a pH of between 0.5 and 5.5 and at an extraction temperature between about 15° C. and 25° C.; and collagen. 18. An osteogenic composition comprising: demineralized bone particles enriched with dried, acid-soluble, demineralized bone extraction product derived from demineralized bone contacted with extraction medium at a pH of between 0.5 and 5.5 and at an extraction temperature between about 15° C. and 25° C.; collagen and tricalcium phosphate. 19. An osteogenic composition comprising: demineralized bone particles enriched with dried, acid-soluble, demineralized bone extraction product derived from demineralized bone contacted with extraction medium at a pH of between 0.5 and 5.5 and at an extraction temperature between about 15° C. and 25° C.; collagen, tricalcium phosphate and reverse phase medium.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (34)
Jefferies Steven R. (5802 Leith Walk Baltimore MD 21239), Bone graft material for osseous defects and method of making same.
Poser James W. (12180 W. 18th Dr. Lakewood CO 80215) Benedict James J. (13206 W. 33rd Pl. Golden CO 80401), Osteoinductive protein mixtures and purification processes.
Bogdansky Simon (Marlboro NJ) O\Leary Robert K. (Spring Lake NJ), Swollen demineralized bone particles, flowable osteogenic composition containing same and use of the composition in the.
Bhat, Archana; Kunjachan, Vipin; Geisler, Chris; Adams, Allison; Grimes, Christine, Biomaterial compositions, implants, and methods of making the same.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.