IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
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| 국제특허분류(IPC7판) |
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| 출원번호 |
UP-0562304
(2006-11-21)
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| 등록번호 |
US-7819842
(2010-11-15)
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발명자
/ 주소 |
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| 출원인 / 주소 |
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| 대리인 / 주소 |
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| 인용정보 |
피인용 횟수 :
3 인용 특허 :
58 |
초록
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A therapy delivery system for the intermittent delivery of biologics, chemicals, or pharmaceuticals into tissues involves a chronically implantable guide tube having a guide cannula with a proximal and a distal end, an access port mounted on the proximal end of the guide cannula and adapted for chro
A therapy delivery system for the intermittent delivery of biologics, chemicals, or pharmaceuticals into tissues involves a chronically implantable guide tube having a guide cannula with a proximal and a distal end, an access port mounted on the proximal end of the guide cannula and adapted for chronic implantation into a patient, a first stop mounted near the distal end of the guide cannula and a delivery cannula insertable into the lumen of the guide cannula through the access port. The delivery cannula mechanically interacts with the first stop and is designed to prevent the delivery cannula from extending beyond a predetermined distance from the distal end of the guide cannula. A tissue-piercing tip may be attached to the distal end of the delivery cannula. A stylet may be used to occupy the lumen of the guide cannula when the delivery cannula is not in use.
대표청구항
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What is claimed: 1. A therapy delivery system comprising: a chronically implantable guide tube comprising: a guide cannula having a proximal end and a distal end; an access port mounted on the proximal end of the guide cannula and adapted for chronic implantation into a patient; and a first stop mo
What is claimed: 1. A therapy delivery system comprising: a chronically implantable guide tube comprising: a guide cannula having a proximal end and a distal end; an access port mounted on the proximal end of the guide cannula and adapted for chronic implantation into a patient; and a first stop mounted near the distal end of the guide cannula, wherein the first stop is closer to the distal end than the proximal end; and a delivery cannula insertable into the guide cannula through the access port, the delivery cannula comprising a second stop adapted to mechanically interact with the first stop; wherein the relative positions of the first stop and the second stop prevent a distal end of the delivery cannula from distally extending beyond a predetermined distance from the distal end of the guide cannula. 2. The therapy delivery system of claim 1, wherein the distal end of the delivery cannula comprises a tissue-piercing tip. 3. The therapy delivery system of claim 1, wherein the first stop comprises a flange. 4. The therapy delivery system of claim 3, wherein the flange is disposed at the distal end of the guide cannula. 5. The therapy delivery system of claim 1 further comprising a stylet insertable into the guide cannula, the stylet adapted to plug at least a distal region of the guide cannula. 6. The therapy delivery system of claim 5, wherein the stylet comprises a chemical having antibiotic, antibacterial, or antimicrobial properties. 7. The therapy delivery system of claim 6, wherein the chemical comprises a pharmaceutical agent comprising an antibiotic, or an anti-inflammatory. 8. The therapy delivery system of claim 6, wherein the chemical comprises an antibacterial or an antimicrobial agent comprising copper silicate, silver silica, colloidal silver, platinum black, tobramycin and bone cement, or alkylated polyethyleneimine or any combinations thereof. 9. The therapy delivery system of claim 5, wherein the stylet consists of tissue-compatible materials, and wherein a distal end and a proximate end of the stylet are formed of different tissue-compatible materials. 10. The therapy delivery system of claim 9, wherein the distal end of the stylet is formed of a tissue-compatible material and the proximate end with a tissue-compatible material having antibacterial properties. 11. The therapy delivery system of claim 1, wherein the guide cannula comprises a first radiopaque marker. 12. The therapy delivery system of claim 11, wherein the first radiopaque marker is disposed on the distal end of the guide cannula. 13. The therapy delivery system of claim 11, further comprising a plurality of the first radiopaque marker disposed along the length of the guide cannula for fluoroscopic or X-ray confirmation of the guide cannula trajectory. 14. The therapy delivery system of claim 1, wherein the delivery cannula is formed from a flexible material to prevent advancement beyond the first stop mounted on the distal end of the guide cannula. 15. The therapy delivery system of claim 1, wherein the delivery cannula comprises a second radiopaque marker. 16. The therapy delivery system of claim 15, wherein the second radiopaque marker is disposed on the distal end of the delivery cannula. 17. The therapy delivery system of claim 15, further comprising a plurality of the second radiopaque markers disposed along the length of the delivery cannula for fluoroscopic or X-ray confirmation of the delivery cannula trajectory. 18. A therapy delivery method comprising: implanting a guide tube within a patient, a distal section of the guide tube comprising a first stop, a proximal end of the guide tube comprising an access port, wherein the first stop is closer to a distal end of the guide tube than to the proximal end; inserting into the proximal end of the guide tube a first delivery cannula, the first delivery cannula having a second stop; feeding the first delivery cannula into the guide tube until the first stop contacts the second stop; delivering a pharmaceutical into the first delivery cannula; and extracting the first delivery cannula. 19. The therapy delivery method of claim 18 further comprising inserting into the guide tube a stylet after extracting the first delivery cannula, the stylet adapted to plug a distal end of the guide tube. 20. The therapy delivery method of claim 19 further comprising: extracting the stylet from the guide tube; inserting into the proximal end of the guide tube a second delivery cannula, the second delivery cannula having a third stop; feeding the second delivery cannula into the guide tube until the first stop contacts the third stop; delivering a second pharmaceutical into the second delivery cannula; and extracting the second delivery cannula. 21. The therapy delivery method of claim 18, wherein the guide tube is implanted within a brain of the patient. 22. The therapy delivery method of claim 21, further comprising locating a pre-determined location within the brain using a mapping means. 23. The therapy delivery method of claim 18 wherein said pharmaceutical is selected from the group consisting of bioactive drugs, viral vectors, and proteins.
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