초록 ▼

Bone implantable devices and methodologies permit careful application of biologically active substances and management of bone growth processes. The device includes a body defining a carrier receiving area for locating adjacent bone. Carrier material is located in the carrier receiving area. Substan

Bone implantable devices and methodologies permit careful application of biologically active substances and management of bone growth processes. The device includes a body defining a carrier receiving area for locating adjacent bone. Carrier material is located in the carrier receiving area. Substance is delivered onto carrier material through a port. A pathway delivers substance from the carrier receiving area to the bone surface. The body may be in the form of a spinal fusion cage, facet fusion screw, artificial joint, bone fixation plate, interbody graft, IM nail, hip stem, or other bone-to-bone appliances or bone-to-device appliances. In use, carrier is installed in the carrier receiving area of the device. The device is then implanted adjacent a bone. The substance is applied to the carrier for subsequent delivery to the bone. By doping carrier material after device implantation, inadvertent contact of the substance with non-target bone is more easily eliminated.

대표청구항 ▼

What is claimed is: 1. An interbody spine fusion cage for fusing adjacent vertebrae, said spinal fusion cage comprising: a cage body defining an outside surface; a carrier receiving area defined by said cage body; an un-doped carrier material loaded in said carrier receiving area; a port that commu

What is claimed is: 1. An interbody spine fusion cage for fusing adjacent vertebrae, said spinal fusion cage comprising: a cage body defining an outside surface; a carrier receiving area defined by said cage body; an un-doped carrier material loaded in said carrier receiving area; a port that communicates said outside surface with said carrier receiving area for facilitating delivery of a biologically active substance onto said un-doped carrier material; a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to a target bone structure; an end cap on an end of said cage body for enclosing said carrier receiving area; wherein said port is located in said end cap; and further comprising: a plug in said port adapted to be penetrated by a delivery device. 2. An interbody spine fusion cage according to claim 1 wherein: said delivery device is a syringe. 3. An implantable device for locating within a body, said implantable device comprising: a body defining an outside surface; a carrier receiving area defined by said body; an un-doped carrier material loaded in said carrier receiving area; a port that communicates said outside surface with said carrier receiving area for facilitating delivery of a biologically active substance onto said un-doped carrier material; a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to a target bone structure; a plug in said port adapted to be penetrated by a syringe; and the interbody spine fusion cage further comprising: a substantially solid end cap on an end of said cage body wherein said end cap encloses said carrier receiving area; and wherein said port is located in said end cap. 4. An interbody spine fusion cage for fusing adjacent vertebrae, said spinal fusion cage comprising: a cage body defining an outside surface; a carrier receiving area defined by said cage body; an un-doped collagen carrier material loaded in said carrier receiving area; a port that communicates said outside surface with said carrier receiving area for facilitating delivery of a biologically active substance onto said un-doped carrier material; a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to a target bone structure; a plug in said port adapted to be penetrated by a syringe; a substantially solid end cap on an end of said cage body wherein said end cap encloses said carrier receiving area; and wherein said port is located in said end cap. 5. An implantable device for locating within a body, said implantable device comprising: a body defining an outside surface; a carrier receiving area defined by said body; an un-doped collagen carrier material loaded in said carrier receiving area; a port that communicates said outside surface with said carrier receiving area for facilitating delivery of a biologically active substance onto said un-doped carrier material; a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to a target bone structure; a plug in said port adapted to be penetrated by a syringe; a substantially solid end cap on an end of said cage body wherein said end cap encloses said carrier receiving area; and wherein said port is located in said end cap. 6. A bone implantable device for locating adjacent a target bone structure, said bone implantable device comprising: a body defining an outside surface; a carrier receiving area defined by said body; a pre-loaded collagen carrier material in said carrier receiving area, said pre-loaded collagen carrier material comprising a biologically active substance; a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to the target bone structure; the interbody spine fusion cage further comprising: a substantially solid end cap on an end of said cage body wherein said end cap encloses said carrier receiving area; and wherein a port is located in said end cap; a plug in said port, said plug adapted to be penetrated by a syringe. 7. A bone implantable device for locating adjacent a target bone structure, said bone implantable device comprising: a body defining an outside surface; a carrier receiving area defined by said body; a pre-loaded sponge material in said carrier receiving area, said pre-loaded sponge material comprising a biologically active substance; a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to the target bone structure; the interbody spine fusion cage further comprising: a substantially solid end cap on an end of said cage body wherein said end cap encloses said carrier receiving area; and wherein a port is located in said end cap; a plug in said port, said plug adapted to be penetrated by a syringe.