A medical device (40) including a collagenous biomaterial (10) for causing embolus and treating an aneurysm. The collagenous biomaterial (10) includes a small intestine submucosa (12) that is configured into various components (16) for causing a vascular occlusion or a packing aneurysm lumen.
대표청구항▼
What is claimed is: 1. A method for achieving full occlusion of a vascular vessel of a patient, comprising delivering to the vessel an embolization device comprising a harvested remodelable submucosal tissue, the embolization device, upon delivery to the vessel, maintaining remodelable submucosal t
What is claimed is: 1. A method for achieving full occlusion of a vascular vessel of a patient, comprising delivering to the vessel an embolization device comprising a harvested remodelable submucosal tissue, the embolization device, upon delivery to the vessel, maintaining remodelable submucosal tissue in the vessel for a period of time sufficient for said remodelable submucosal tissue to promote cellular invasion and ingrowth into the embolization device and to become remodeled with tissue of the patient so that an all-natural, remodeled tissue blockage is generated in the vessel and remains in the vessel fully occluding the vessel. 2. The method of claim 1, wherein the embolization devices comprises a coil formed with said remodelable submucosal tissue. 3. The method of claim 1, wherein the submucosa is porcine submucosa. 4. The method of claim 1, wherein the embolization device comprises at least one sheet of submucosa. 5. The method of claim 1, wherein the device comprises a particulate material comprising submucosa. 6. A method for achieving full occlusion of a vascular vessel of a patient, comprising delivering to the vessel an embolization device comprising a harvested remodelable collagenous extracellular matrix biomaterial, the embolization device, upon delivery to the vessel, maintaining remodelable collagenous extracellular matrix biomaterial in the vessel for a period of time sufficient for the harvested remodelable collagenous extracellular matrix biomaterial to promote a healing response in an area of the vascular vessel occluded with the harvested remodelable collagenous extracellular matrix biomaterial and to become remodeled with tissue of the patient so that an all-natural, remodeled tissue blockage is generated in the vessel and remains in the vessel fully occluding the vessel. 7. The method of claim 6, wherein the biomaterial comprises submucosa. 8. The method of claim 6, wherein the device comprises a coil formed with said remodelable collagenous extracellular matrix biomaterial. 9. The method of claim 6, wherein the biomaterial comprises porcine submucosa. 10. The method of claim 6, wherein the device comprises at least one sheet of the remodelable collagenous extracellular matrix biomaterial. 11. The method of claim 6, wherein a pharmacologic agent is disposed on the biomaterial. 12. The method of claim 6, wherein the biomaterial comprises a material selected from submucosa, pericardium, basement membrane, and amniotic membrane. 13. The method of claim 6, wherein the biomaterial also comprises a radiopaque marker. 14. The method of claim 6, wherein the biomaterial is injectable. 15. The method of claim 6, wherein the biomaterial is in comminuted form. 16. The method of claim 7, wherein the biomaterial is in comminuted form. 17. A method for occluding a blood vessel in a patient, comprising: providing an embolization device free from any metallic component, the embolization device comprising a thrombogenic collagenous biomaterial harvested from animal tissue and containing at least one biotropic agent selected from a proteoglycan, a growth factor, a glycoprotein, and a glycosaminoglycan; delivering the embolization device to a blood vessel of the patient in such a manner as to fill the blood vessel, to cause formation of an embolus in the blood vessel, and to cause a full occlusion of the blood vessel; and wherein the thrombogenic collagenous biomaterial is biodegradable and remains in the blood vessel for a sufficient period of time following delivery to promote a healing response in the patient so as to result in the generation of an all natural blockage fully occluding the blood vessel in the patient. 18. The method of claim 17, wherein the thrombogenic collagenous biomaterial comprises submucosa, pericardium, basement membrane, or amniotic membrane. 19. The method of claim 18, wherein the thrombogenic collagenous biomaterial comprises amniotic membrane. 20. The method of claim 18, wherein the thrombogenic collagenous biomaterial comprises submucosa. 21. A method for occluding a blood vessel in a patient, comprising: advancing a delivery catheter into the blood vessel of the patient; delivering an embolization device from the delivery catheter and into the blood vessel, the embolization device comprising a thrombogenic collagenous biomaterial sheet harvested from animal tissue or a thrombogenic component prepared the thrombogenic collagenous biomaterial sheet, wherein the thrombogenic collagenous biomaterial sheet contains at least one biotropic agent selected from a proteoglycan, a growth factor, a glycoprotein, and a glycosaminoglycan, and further wherein said delivering is conducted so as to fill the blood vessel, to promote the formation of thrombus in the blood vessel, and to cause a full occlusion of the blood vessel; and wherein the thrombogenic collagenous biomaterial sheet or the thrombogenic component prepared therefrom is biodegradable and remains in the blood vessel for a sufficient period of time following delivery to promote a healing response in the patient so as to result in tissue ingrowth into an area of the blood vessel into which the embolization device is delivered with the generation of an all natural blockage in the blood vessel fully occluding the vessel. 22. The method of claim 21, wherein the embolization device comprises a thrombogenic component prepared from the thrombogenic collagenous biomaterial sheet, wherein the component is a comminuted component, a branched component, a helical component, a spherical component, a cubic component, or a cylindrical component. 23. A method for fully occluding a blood vessel or filling an aneurysm in a patient, comprising: advancing a delivery catheter into the blood vessel or the aneurysm; delivering an embolization device from the delivery catheter and into the blood vessel or the aneurysm, the embolization device comprising a thrombogenic collagenous biomaterial harvested from animal tissue and containing at least one biotropic agent selected from a proteoglycan, a growth factor, a glycoprotein, and a glycosaminoglycan, and further wherein said delivering is conducted so as to cause formation of an embolus and to fill and fully occlude flow in the blood vessel or to fill the aneurysm; and wherein the thrombogenic collagenous biomaterial is biodegradable and remains in the blood vessel or the aneurysm for a sufficient period of time following delivery to promote a healing response in the patient so as to result in tissue ingrowth into the blood vessel or the aneurysm so that an all-natural blockage is generated in the blood vessel or the aneurysm and remains in the blood vessel or the aneurysm. 24. The method of claim 23, which is for filling an aneurysm. 25. The method of claim 23, which is for fully occluding a blood vessel. 26. A method for filling an aneurysm in a patient, comprising: advancing a delivery catheter into the aneurysm of the patient; delivering an embolization device from the delivery catheter and into the aneurysm, the embolization device comprising a thrombogenic collagenous biomaterial harvested from animal tissue and containing at least one biotropic agent selected from a proteoglycan, a growth factor, a glycoprotein, and a glycosaminoglycan, and further wherein said delivering is conducted so as to fill the aneurysm; and wherein the thrombogenic collagenous biomaterial is biodegradable and remains in the aneurysm for a sufficient period of time following delivery to promote a healing response in the patient so as to result in tissue growth into the aneurysm so that an all-natural blockage is generated in the aneurysm and remains in the aneurysm. 27. The method of claim 26, wherein the embolization device comprises a thrombogenic component prepared from a sheet of the thrombogenic collagenous biomaterial, wherein the component is a comminuted component, a branched component, a helical component, a spherical component, a cubic component, or a cylindrical component. 28. The method of claim 27, wherein the component is a comminuted component or a helical component. 29. The method of claim 28, wherein the thrombogenic collagenous biomaterial also comprises a radiopaque substance.
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Light Nicholas D. (Doune GBX) MacGregor James (Glasgow GBX) Harvey Wilson (Gargunnock GBX) Watt Paul W. (Broomridge GBX), Absorbable structures for ligament and tendon repair.
Silver Frederick H. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Doillon Charles J. (Edison NJ) Weadock Kevin (Piscataway NJ) Whyne Conrad (Edgewood MD), Biodegradable matrix and methods for producing same.
Brendel Klaus (Tucson AZ) Duhamel Raymond C. (Tucson AZ), Body implants of extracellular matrix and means and methods of making and using such implants.
Levy Robert J. (Ann Arbor MI) Sintov Amnon (Jerusalem ILX), Calcification-resistant materials and methods of making same through use of multivalent cations.
Levy Robert J. (Ann Arbor MI) Sintov Amnon (Ann Arbor MI), Calcification-resistant materials and methods of making same through use of trivalent aluminum.
Kemp Paul D. (Cambridge MA) Falco Lisa (Medford MA) Regan Kathleen (Boston MA) Bell Eugene (Boston MA), Collagen compositions and methods for preparation thereof.
Kemp Paul D. (Winchester MA) Carr ; Jr. Robert M. (Boston MA) Maresh John G. (Somerville MA) Cavallaro John (Gloucester MA) Gross Jerome (Waban MA), Collagen threads.
Chu George H. (Sunnyvale CA) Ogawa Yasushi (Pacifica CA) McPherson John M. (Hopkinton MA) Ksander George (Redwood City CA) Pratt Bruce (Union City CA) Hendricks Diana (Brea CA) McMullin Hugh (San Bru, Collagen wound healing matrices and process for their production.
Chu George H. (Sunnyvale CA) Ogawa Yasushi (Pacifica CA) McPherson John M. (Hopkinton MA) Ksander George (Redwood City CA) Pratt Bruce (Union City CA) Hendricks Diana (Brea CA) McMullin Hugh (San Bru, Collagen wound healing matrices and process for their production.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Leshchiner Adolf (Fairview NJ) Larsen Nancy E. (Southfield NY) Balazs Endre A. (Ft. Lee NJ) Hilal Sadek K. (Englewood Cliffs NJ), Compositions for therapeutic percutaneous embolization and the use thereof.
Sawan Samuel P. (Tyngsboro MA) Dollinger Harli M. (Dracut MA) Horne ; Jr. Herbert W. (Framingham MA), Contraceptive intracervical device and novel nonsystemic agents for the prevention of conception and disease.
Zaneveld Lourens J. D. (900 N. Lake Shore Dr. Chicago IL 60611) Burns James W. P. (146 S. Elgin Ave. Forest Park IL 60130), Device and method for reversibly occluding a body duct.
Conston Stanley R. (San Carlos CA) Dapper Gregory S. (Newark CA) Murphy Aileen L. (Menlo Park CA) Raeder-Devens Jennifer (Oakland CA) Yamamoto Ronald (San Francisco CA), Embolization plugs for blood vessels.
Badylak Stephen F. (2610 Nottingham Pla. West Lafayette IN 47906) Demeter Robert J. (360 Cottonwood Dr. Mooresville IN 46158) Hiles Michael (3817 Cologne Ct. Indianapolis IN 46208) Voytik Sherry (271, Fluidized intestinal submucosa and its use as an injectable tissue graft.
Badylak Stephen F. (West Lafayette IN) Demeter Robert J. (Mooresville IN) Hiles Michael (Indianapolis IN) Voytik Sherry (West Lafayette IN) Knapp ; Jr. Peter M. (Carmel IN), Fluidized intestinal submucosa and its use as an injectable tissue graft.
Rhee Woonza M. (3845 LaDonna Ave. Palo Alto CA 94306) Berg Richard A. (660 S. Springer Rd. Los Altos CA 94024), Glycosaminoglycan-synthetic polymer conjugates.
Badylak Stephen F. (W. Lafayette IN) Geddes Leslie A. (W. Lafayette IN) Shelbourne K. Donald (Indianapolis IN) Lantz Gary C. (Lafayette IN) Coffey Arthur C. (Indianapolis IN), Graft for promoting autogenous tissue growth.
Badylak Stephen F. (W. Lafayette IN) Geddes Leslie A. (W. Lafayette IN) Shelbourne K. Donald (Indianapolis IN) Lantz Gary C. (Lafayette IN) Coffey Arthur C. (Indianapolis IN), Graft for promoting autogenous tissue growth.
Kensey Kenneth (Chester Springs PA) Nash John (Downingtown PA) Evans Douglas (King of Prussia PA), Hemostatic puncture closure system and method of use.
Kensey Kenneth (Chester Springs PA) Nash John (Dowington PA) Evans Douglas (Downington PA), Hemostatic puncture closure system including vessel location device and method of use.
Kelman Charles D. (269 Grand Central Pkwy. Floral Park NY 11005) DeVore Dale P. (3 Warwick Dr. Chelmsford MA 01824), Human collagen processing and autoimplant use.
Wahlig Helmut (Darmstadt DEX) Dingeldain Elvira (Dreieich DEX) Braun Dietrich (Darmstadt-Arheilgen DEX), Medicinally useful, shaped mass of collagen resorbable in the body.
Livesey Stephen A. (Eltham TX AUX) del Campo Anthony A. (Houston TX) Nag Abhijit (Houston TX) Nichols Ken B. (The Woodlands TX) Coleman Christopher (Houston TX), Method for processing and preserving collagen-based tissues for transplantation.
Kensey Kenneth (Chester Springs PA) Clupper Harold (West Chester PA), Methods and instruments for performing medical procedures percutaneously without a trocar.
Whalen, II, Thomas J.; Tran, Chinh Ngoc; Hayman, Douglas Ray; Roth, Noah Michael; Moret, Jacques; Greff, Richard J., Methods for embolizing vascular sites with an embolizing composition.
Patel Umesh H. ; Hiles Michael C. ; Whitson Bryan A. ; Cheng Boyle ; Badylak Stephen F. ; Kokini Klod, Multilayered submucosal graft constructs and method for making the same.
Obligin Alan (Catonsville MD) Xia Du W. (Chengdu Sichuan MA CNX) Silberman-Hazony Ruth (Brookline MA) Rawls H. Ralph (Boston MA) Cabasso Israel (Syracuse NY) Smid Johannes (Lafayette NY), Novel radiopaque barium polymer complexes, compositions of matter and articles prepared therefrom.
Kensey Kenneth (Chester Springs PA) Nash John (Downingtown PA) Evans Douglas (King of Prussia PA), Plug device with pulley for sealing punctures in tissue and methods of use.
Eckmayer Zdenek (Weinheim DEX) Janzen Ernst (GR Laren NLX) Rttgers Gnter (Stolberg DEX), Process for the manufacture of collagen membranes used for hemostasis, the dressing of wounds and for implants.
Anhuser Dieter (Melsbach DEX) Roreger Michael (Neuwied DEX), Process for the production of collagen foams in the form of continuous tapes and their use in medicine, cosmetics and hy.
Zimmermann Eberhard (Mnster-Nienberge DEX) Stroetmann Michael (Mnster DEX), Resorptive sheet material for closing and healing wounds and method of making the same.
Dormandy ; Jr. Ray H. (South San Francisco CA) Bell Julie D. (South San Francisco CA), System for artificial vessel embolization and devices for use therewith.
Kensey Kenneth (Chester Springs PA) Nash John E. (Downington PA) Evans Douglas (Devon PA), System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating.
Kensey Kenneth (Chester Springs PA) Nash John E. (Downington PA) Evans Douglas (Devon PA), System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating.
Badylak Stephen F. (West Lafayette IN) Geddes Leslie A. (West Lafayette IN) Lantz Gary (Lafayette IN) Coffey Arthur C. (Indianapolis IN), Tissue graft composition.
Badylak Stephen F. (West Lafayette IN) Geddes Leslie A. (West Lafayette IN) Lantz Gary (Lafayette IN) Coffey Arthur C. (Indianapolis IN), Tissue graft composition.
Badylak Steven F. (2610 Nottingham Pl. West Lafayette IN 47906) Demeter Robert J. (360 Cottonwood Dr. Mooresville IN 46158) Hiles Michael (3817 Cologne Ct. Indianapolis IN 46208) Voytik Sherry (271 S, Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor.
Flaherty, J. Christopher; Lamson, Theodore C., Transluminally deliverable vascular blockers and methods for facilitating retrograde flow of arterial blood through veins.
Ritchart Mark (Santa Clara CA) Mariant Mike (Santa Clara CA) Sepetka Ivan (Santa Clara CA) Engelson Erik (Portola Valley CA), Vaso-occlusion coil and method.
Bachman, Anthony; Roue, Chad; Jensen, Marc; Walsh, Mike; Cameron, Scott; Gendreau, Michael; Abrams, Robert M., Devices, systems and methods for enclosing an anatomical opening.
Bachman, Anthony; Roue, Chad; Jensen, Marc; Walsh, Mike; Cameron, Scott; Gendreau, Michael; Abrams, Robert M., Devices, systems and methods for enclosing an anatomical opening.
Eskridge, Joseph; Clarke, Gilbert; Pease, Matthew; Mast, Gregory Martin; Muskivitch, John Conrad, Methods and systems for endovascularly clipping and repairing lumen and tissue defects.
Paul, Jr., Ram H.; Flagle, Jacob A.; Case, Brian C., Tubular devices having reversible components for deployment of endoluminal occluders and related methods and systems.
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