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Charge-dynamic polymers and delivery of anionic compounds 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/00
출원번호 US-0886161 (2004-07-07)
등록번호 US7883720 (2011-01-26)
발명자 / 주소
  • Lynn, David M.
  • Miller, Adam D.
출원인 / 주소
  • Wisconsin Alumni Research Foundation
대리인 / 주소
    Greenlee Sullivan PC
인용정보 피인용 횟수 : 6  인용 특허 : 40

초록 ▼

The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present in

대표청구항 ▼

What is claimed is: 1. An interpolyelectrolyte complex comprising:a. a dynamic charge state cationic polymer having a polymeric backbone formed from monomeric units, and one or more removable functional groups attached to the polymeric backbone through one or more labile linkages, wherein the one or

이 특허에 인용된 특허 (40)

  1. Fazio Robert C. (Yorba Linda CA) Taylor Lloyd D. (Lexington MA), 2-(4-alkenylphenyl)-5-oxazolones and polymers thereof.
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  2. Muller Egbert,DEX ; Badel Kerstin,DEX ; Muller Andreas,DEX ; Herbert Stephan,DEX ; Seiler Anna,DEX, Affinity supports containing ligands bound to oxirane groups.
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  3. Moren Dean M. (North St. Paul MN) Heilmann Steven M. (Afton MN) Krepski Larry R. (White Bear Lake MN) Rasmussen Jerald K. (Stillwater MN), Azlactone Michael adducts.
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  4. Greenwald Richard B. (Somerset NJ), Azlactone activated polyalkylene oxides conjugated to biologically active nucleophiles.
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  5. Fazio Robert C. (Arlington MA) Taylor Lloyd D. (Lexington MA), Azlactone copolymers.
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  6. Coleman Patrick L. (Minneapolis MN) Kotnour Thomas A. (Faribault MN) Rolando Richard J. (Oakdale MN), Azlactone graft copolymers.
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  7. Coleman Patrick L. (St. Paul MN) Rolando Richard J. (St. Paul MN), Azlactone graft copolymers.
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  8. Rasmussen Jerald K. (Stillwater MN) Heilmann Steven M. (North St. Paul MN) Palensky Frederick J. (St. Paul MN), Azlactone-functional compounds.
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  9. Coleman Patrick L. (Minneapolis MN) Heilmann Steven M. (Afton MN) Kangas Steven L. (Woodbury MN) Rasmussen Jerald K. (May Township ; Washington County MN) Rolando Richard J. (Oakdale MN) Stahl Julie , Azlactone-functional polymer blends, articles produced therefrom and methods for preparing both.
    상세보기
  10. Ahn, Cheol Hee; Kim, Sung Wan, Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents.
    상세보기
  11. Langer,Robert S.; Lynn,David M.; Putnam,David; Amiji,Mansoor M.; Anderson,Daniel G., Biodegradable poly(β-amino esters) and uses thereof.
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  12. Burgess Stephen W. ; Shaw Walter A., Cationic polymers for nucleic acid transfection and bioactive agent delivery.
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  13. Sagara, Kazuyoshi, Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier.
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  14. Heilmann Steven M. ; Babu Gaddam N. ; Krepski Larry R. ; Smith ; II Howell K. ; Mickus Daniel E., Chromophoric photocrosslinking compound.
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  15. Curiel David T. ; Birnstiel Max L.,ATX ; Cotten Matthew,ATX ; Wagner Ernst,ATX ; Zatloukal Kurt,ATX ; Plank Christian,ATX ; Oberhauser Berndt,ATX ; Schmidt Walter G. M.,ATX, Composition for introducing nucleic acid complexes into higher eucaryotic cells.
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  16. Wolff, Jon A.; Hagstrom, James E.; Monahan, Sean D.; Budker, Vladimir; Rozema, David B.; Slattum, Paul M., Compositions and methods for drug delivery using amphiphile binding molecules.
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  17. Rice, Kevin G.; Adami, Roger C.; McKenzie, Donald L.; Collard, Wendy T.; Kwok, Kai Y.; Park, Youmie; Yang, Yongsheng, Crosslinked DNA condesate compositions and gene delivery methods.
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  18. Rasmussen Jerald K. (Stillwater MN) Heilmann Steven M. (North St. Paul MN) Palensky Frederick J. (St. Paul MN), Curable compositions containing azlactone-functional compounds.
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  19. Schacht Etienne H,BEX ; Seymour Leonard C W,GBX ; Ulbrich Karel,CZX, Delivery of nucleic acid materials.
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  20. Jerald K. Rasmussen ; Patrick L. Coleman, Method for cell selection utilizing azlactone-functional supports.
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  21. Huebner Holger (Baldhaur DEX), Method for manufacturing a three-dimensional circuit apparatus.
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  22. Heilmann, Steven M.; Rasmussen, Jerald K.; Palensky, Frederick J., Method of hydrophilizing or hydrophobizing polymers.
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  23. Chang Kenneth (Hopewell Junction NY) Czornyj George (Poughkeepsie NY) Farooq Mukta S. (Hopewell Junction NY) Kumar Ananda H. (Hopewell Junction NY) Pitler Marvin S. (late of Poughkeepsie NY by Peter , Method of making a multilayer thin film structure.
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  24. Lynn,David M.; Vazquez,Eduardo; Langer,Robert; Hammond,Paula T., Methods of making decomposable thin films of polyelectrolytes and uses thereof.
    상세보기
  25. Robert J. Levy ; Vinod Labhasetwar ; Hagit Cohen IL, Microspheres containing condensed polyanionic bioactive agents and methods for their production.
    상세보기
  26. Hubbell, Jeffrey A.; Elbert, Donald L.; Herbert, Curtis B., Multifunctional polymeric tissue coatings.
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  27. Jacobine Anthony F. ; Nakos Steven T., Norbornenyl azlactones.
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  28. Heilmann Steven M. (St. Paul MN) Moren Dean M. (St. Paul MN) Rasmussen Jerald K. (St. Paul MN) Krepski Larry R. (St. Paul MN) Pathre Sadanand V. (St. Paul MN), Oligo (2-alkenyl azlactones).
    상세보기
  29. Heilmann Steven M. (Afton MN) Moren Dean M. (North St. Paul MN) Rasmussen Jerald K. (Stillwater MN) Krepski Larry R. (White Bear Lake MN) Pathre Sadanand V. (Maplewood MN), Oligo(2-alkenyl azlactones).
    상세보기
  30. Jon A. Wolff ; James E. Hagstrom ; Vladimir G. Budker ; Vladimir S. Trubetskoy, Polyampholytes for delivering polyions to a cell.
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  31. Park Jong Sang,KRX ; Choi Young Hun,KRX ; Kim Sung Wan, Polyester analogue of poly-L-lysine as a soluble, biodegradable gene delivery carrier.
    상세보기
  32. Heilmann Steven M. (Afton MN) Rasmussen Jerald K. (Stillwater MN) Krepski Larry R. (White Bear Lake MN) Milbrath Dean S. (Stillwater MN) Coleman Patrick L. (Minneapolis MN), Polymeric supports.
    상세보기
  33. Alexander Victorovich Kabanov ; Valery Yulievich Alakov CA; Sergey V. Vingogradov, Polynucleotide compositions.
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  34. Heilmann Steven M. (North St. Paul MN) Palensky Frederick J. (St. Paul MN) Rasmussen Jerald K. (Stillwater MN), Radiation-curable polymers containing pendant unsaturated peptide groups derived from azlactone polymers.
    상세보기
  35. Holmes Gary L. ; Smith Terrance P. ; Ali Mahfuza B. ; Macomber David W., Reactive polymeric dyes.
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  36. Sabatini, David M., Reverse transfection method.
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  37. Fansler,Duane D.; Lewandowski,Kevin M.; Gaddam,Babu N., Ring-opened azlactone telechelic polymer.
    상세보기
  38. Edwards,Brooks; Geiser,Timothy G.; Menchen,Steven M.; Sparks,Alison L.; Voyta,John C., Solid phases optimized for chemiluminescent detection.
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  39. Abraham J. Domb IL; Zeev Zehavi IL, Stereocomplex polymeric carriers for drug delivery.
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  40. Heilmann Steven M. (Afton MN) Rasmussen Jerald K. (Stillwater MN) Krepski Larry R. (White Bear Lake MN) Milbrath Dean S. (Stillwater MN) Coleman Patrick L. (Minneapolis MN), Variably crosslinked polymeric supports.
    상세보기

이 특허를 인용한 특허 (6)

  1. Lynn, David M.; Miller, Adam D., Charge-dynamic polymers and delivery of anionic compounds.
    상세보기
  2. Dake, Michael D.; Waugh, Jacob M., Compositions and methods for topical application and transdermal delivery of botulinum toxins.
    상세보기
  3. Dake, Michael D.; Waugh, Jacob M., Compositions and methods for topical application and transdermal delivery of botulinum toxins.
    상세보기
  4. Dake, Michael D.; Waugh, Jacob M., Compositions and methods for topical diagnostic and therapeutic transport.
    상세보기
  5. Dake, Michael D; Waugh, Jacob M, Methods for treating pain by topical application and transdermal delivery of botulinum toxin.
    상세보기
  6. Lynn, David M.; Zhang, Jingtao; Liu, Xianghui, Ultrathin multilayered films for controlled release of anionic reagents.
    상세보기

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