초록

Provided herein are methods for enhancing bone mineralization for bone repair or regeneration and compositions and grafts therefor. Methods for screening agents that enhance or modulate NELL-1 gene expression or NELL-1 protein production in a cell are also provided.

대표청구항 ▼

I claim: 1. A method of increasing bone mineralization, the method comprising increasing the concentration of a NELL-1 gene product in an osteogenic cell by administering a NELL-1 gene product in an effective amount to the osteogenic cell;wherein the NELL-1 gene product is a NELL-1 protein or an ost

I claim: 1. A method of increasing bone mineralization, the method comprising increasing the concentration of a NELL-1 gene product in an osteogenic cell by administering a NELL-1 gene product in an effective amount to the osteogenic cell;wherein the NELL-1 gene product is a NELL-1 protein or an osteogenic fragment thereof,wherein the NELL-1 protein comprises the amino acid sequence of SEQ ID NO: 1 or 8.