[특허]Cell assay kit and method

[미국특허] Cell assay kit and method 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/00
출원번호	US-0329380 (2008-12-05)
등록번호	US7998696 (2011-08-03)
발명자 / 주소	Zaugg, Frank Tobias, Renee McManus-Munoz, Silvia Kernen, Peter Ruiz-Taylor, Laurence Wagner, Peter
출원인 / 주소	Zyomyx, Inc.
대리인 / 주소	King & Spalding LLP
인용정보	피인용 횟수 : 8 인용 특허 : 28

초록 ▼

A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

대표청구항 ▼

It is claimed: 1. A method for assaying a cell sample to determine a concentration of cells of a given type in the sample, comprising:(a) adding to a cell sample containing cells of the given cell type, a given quantity of particles which specifically react and bind to the given type of cells, and being effective, when bound to the cells, to allow particle-bound cells and free particles to be separated from non-particle bound cells in the sample based on their greater density or magnetic susceptibility, which allows them to migrate selectively through a selected medium under the influence of force acting on the particles,(b) causing the particle-bound cells and particles in the cell sample to migrate through a microchannel column containing the selected medium, by subjecting the sample to such force for a period of time sufficient to cause the particle-bound cells and particles, but not non-particle-bound cells, to migrate to the bottom of the column, where the added particles make an appreciable contribution to the volume of the particle-bound cells and particles that migrate to the bottom of the column, and account for a known volume in the column, and(c) determining the volume of cells of the given type in the sample by measuring the column height of particle-bound cells and particles that migrated to the bottom of the column in step (b), where the measured column height is adjusted by the known volume of particles in the column, and where the volume determined from the adjusted column height equates to the concentration of cells of the given type in the sample.

이 특허에 인용된 특허 (28) 인용/피인용 타임라인 분석

Wardlaw Stephen C. (Branford CT), Apparatus and method for measuring white blood cell and platelet concentrations in blood.
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Terstappen, Leon W. M. M.; Rao, Galla C., Apparatus and methods for capture and analysis of particulate entities.
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Kristen L. Manion (2600 San Leandro Blvd. ; Apt. 1508 San Leandro CA 94578) Wardlaw Stephen C. (191 N. Cove Rd. Old Saybrook CT 06475) Levine Robert A. (31 Pilgrim La. Guilford CT 06437), Apparatus for measuring blood constituent counts.
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Levine Robert A. ; Wardlaw Stephen C. ; Terstappen Leon W. M. M. ; Manion Kristen L. ; Rodriguez Rodolfo R. ; Malick Adrien P. ; Dhanesar Subhash ; Lovell Stephen J. ; Ozinskas Alvydas J., Assay of blood or other biologic samples for target analytes.
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Levine Robert A. ; Wardlaw Stephen C., Assembly for detecting blood-borne parasites and measuring blood sample parameters in a centrifuged sample of blood.
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Wardlaw Stephen C. (128 Sunset Hill Dr. Branford CT 06405), Blood count reader.
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Wang,Evelyn; Casagrande,Rocco; Kendale,Amar; Kim,Enoch; Ostuni,Emanuele; Schueller,Olivier, Cell isolation and screening device and method of using same.
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Siegel, Donald L., Compositions and methods for detection of antibody binding to cells.
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Bouboulis, Denis A., Erythrocyte sedimentation rate (ESR) test measurement instrument of unitary design and method of using the same.
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Liberti Paul A. ; Wang Yuzhou, Magnetic immobilization and manipulation of biological entities.
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Terstappen, Leon W. M. M.; Dolan, Gerald, Magnetic separation apparatus and methods.
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Wardlaw Stephen Clark (16 Pine Orchard Road Branford CT 06405) Levine Robert Aaron (31 Pilgrim Lane Guilford CT 06437) Massey ; III James Vincent (80 Driftwood Lane Trumbull CT 06610), Material layer volume determination.
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Wardlaw, Stephen C., Method and apparatus for measuring blood constituent counts.
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Levine Robert A. ; Wardlaw Stephen C., Method for analyzing blood samples.
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Rimm, David L.; Wardlaw, Stephen C.; Levine, Robert A.; Fiedler, Paul, Method for assaying whole blood for the presence or absence of circulating cancer or other target cell fragments.
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Fodstad, Øystein; Kvalheim, Gunnar, Method for detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations.
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Mahant, Vijay; Doneen, Byron, Methods and apparatus for separation of biological fluids.
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Van Vlasselaer Peter (Sunnyvale CA), Methods for enriching fetal cells from maternal body fluids.
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Liberti Paul A. ; Wang Yuzhou, Methods for magnetic immobilization and manipulation of cells.
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Wardlaw Stephen C. (128 Sunset Hill Dr. Branford CT 06405) Levine Robert A. (31 Pilgram La. Guilford CT 06437), Optical viewing instrument including capillary tube and holder.
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Paterlini-Brechot, Patrizia, Prenatal diagnosis method on isolated foetal cell of maternal blood.
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Bisconte Sconte De Saint Julien Jean-Claude,FRX, Process and installations for separation of magnetic particles in a fluid for biological analysis, and application of said process.
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Levine Robert A. (31 Pilgrim La. Guilford CT 06437) Massey ; III James V. (80 Driftwood La. Trumbull CT 06610) Wardlaw Stephen C. (128 Sunset Hill Dr. Branford CT 06405), Process for detection of blood-borne parasites.
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Anderson, Norman G., Rapid particle detection.
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Fong,Whalley K., Sensitive immunochromatographic assay.
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Vlasselaer Peter Van (Sunnyvale CA), Separation apparatus and method.
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Goodrich Raymond P. ; Green Todd Curtis, System for using ligands in particle separation.
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Saunders Alexander (San Carlos CA) Zarowitz Michael Allan (San Carlos CA), Two-phase optical assay.
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이 특허를 인용한 특허 (8) 인용/피인용 타임라인 분석

Park, Jongmyeon, Apparatus for and method of separating target matter.
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Zaugg, Frank; Tobias, Renee; McManus-Munoz, Silvia; Kernen, Peter; Ruiz-Taylor, Laurence; Wagner, Peter, Cell assay kit and method.
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Graham, Henry A.; Gorman, John G.; Rowell, James P., Detection of specific antigens in a population of antigens.
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Graham, Henry A.; Gorman, John G.; Rowell, James P., Detection of specific antigens in a population of antigens.
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Yu, Liping; Warner, Brian David; Trotter, Joseph T., Devices and methods for manipulating components in a fluid sample.
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Yu, Liping; Warner, Brian David; Trotter, Joseph T., Devices and methods for manipulating components in a fluid sample.
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Yu, Liping; Warner, Brian David; Trotter, Joseph T., Devices and methods for manipulating components in a fluid sample.
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Yu, Liping, Devices and methods for separating magnetically labeled moieties in a sample.
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A	생활필수품
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A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Cell assay kit and method 원문보기