IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0156085
(2008-05-29)
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등록번호 |
US8003705
(2011-08-08)
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발명자
/ 주소 |
- Sawhney, Amarpreet S.
- Bennett, Steven
- Edelman, Peter G.
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
1 인용 특허 :
165 |
초록
▼
Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for maki
Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable, or not, are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers. Embodiments that include hydrogels having isolated hydrolytically degradable esters are set forth. Embodiments including the use of low molecular weight amines to make degradable hydrogels are also set forth.
대표청구항
▼
The invention claimed is: 1. A method for making a medical device, the method comprising:providing at least a first biocompatible precursor having least two electrophilic functional groups, and providing at least a second biocompatible precursor comprising at least two primary amine functional group
The invention claimed is: 1. A method for making a medical device, the method comprising:providing at least a first biocompatible precursor having least two electrophilic functional groups, and providing at least a second biocompatible precursor comprising at least two primary amine functional groups; wherein the first biocompatible precursor and the second biocompatible precursor are resistant to enzymatic degradation and at least one of the first biocompatible precursor or second biocompatible precursor comprises at least one isolated hydrolytically degradable ester group; andmixing at least the first biocompatible precursor and the second biocompatible precursor in situ to form a device comprising a crosslinked hydrogel that comprises covalent bonds formed by reaction of the functional groups of the first biocompatible precursor and second biocompatible precursor with each other and further comprising the at least one isolated hydrolytically degradable ester group; wherein the crosslinked hydrogel is resistant to enzymatic degradation, is degradable by hydrolysis of the at least one isolated hydrolytically degradable ester group so that the device is degradable in less than about 180 days, and wherein the second biocompatible precursor has a molecular weight of less than about 2000, wherein the second precursor is a member of the group consisting of ornithine, spermine, spermidine, urea, guanidine, dianmiopimelic acid, diaminobutyric acid, methylornithine, diaminopropionic acid, cystine, lanthionine, cystamine, trioxatridecanediamine, cyclohexanebis(methylamine), tetraethylenepentamine, pentaethylenehexamine, methylenebis(methylcyclohexamine), diaminocyclohexane, n-(2-aminoethyl)-1,3-propanediamine, diaminomethyldipropylamine, iminobispropylamine, bis(hexamethlyene)triamine, triethylenetetramine, bis(aminopropyl)ethylenediamine, bis(2-aminoethyl)-1,3-propanediamine, bis(aminopropyl)propanediamine, diamniomethylpropane, 1,2-diamino-2-methylpropane, 1,3-diaminopentane, dimethylpropanediamine, 2,2-dimethyl 1,3-propanediamine, methylpentanediamine, 2-methyl-1,5 pentanediamine, diaminoheptane, diaminooctane, diaminononane, and diaminododecane.
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