초록 ▼

The present disclosure provides compositions which may be utilized as adhesives or sealants in medical and surgical applications. The compositions may, in embodiments, be formed from the cycloaddition reaction of a first component possessing at least one azide group with a second component possessin

The present disclosure provides compositions which may be utilized as adhesives or sealants in medical and surgical applications. The compositions may, in embodiments, be formed from the cycloaddition reaction of a first component possessing at least one azide group with a second component possessing at least one alkyne group.

대표청구항 ▼

What is claimed is: 1. A method for adhering tissue comprising:contacting a first component possessing at least two alkyne groups with a second component selected from the group consisting of N—((2S,3R,4S,5S,6S)-4,5-diazido-6-(azidomethyl)-2-(benzyloxy)tetrahydro-2H-pyran-3-yl)acetamide, 4,4′-diazi

What is claimed is: 1. A method for adhering tissue comprising:contacting a first component possessing at least two alkyne groups with a second component selected from the group consisting of N—((2S,3R,4S,5S,6S)-4,5-diazido-6-(azidomethyl)-2-(benzyloxy)tetrahydro-2H-pyran-3-yl)acetamide, 4,4′-diazido-2,2′-stilbenedisulfonic acid disodium salt hydrate, (3R,4R,5S,6S)-4-azido-6-(azidomethyl)tetrahydro-2H-pyran-2,3,5-triol, 4,4′-oxybis(azidobenzene), 4,4′-sulfonylbis(azidobenzene), bis[2-(4-azidosalicylamido)ethyl]disulfide, 1,17-diazido-3,6,9,12,15-pentaoxaheptadecane, (2E,6E)-2,6-bis(4-azidobenzylidene)cyclohexanone, tetraazido-pentaerythritol ethoxylate, heptakis-6-azido-6-deoxy-beta-cyclodextrin, and combinations thereof;catalyzing a polymerization of the first component and the second component to form a bioadhesive composition; andadhering the bioadhesive composition to at least one tissue surface.