초록

The invention relates to the discovery that in chronic wounds the expression levels of certain genes are altered relative to the expression levels observed in healthy tissues.

대표청구항 ▼

What is claimed: 1. A method comprisingquantifying expression levels of one or more genes in a wound tissue sample from a wound of a mammalian subject, the wound being at least 7 days old, the one or more genes consisting of one or more of angiotensin II receptor, interleukin I receptor antagonist o

What is claimed: 1. A method comprisingquantifying expression levels of one or more genes in a wound tissue sample from a wound of a mammalian subject, the wound being at least 7 days old, the one or more genes consisting of one or more of angiotensin II receptor, interleukin I receptor antagonist or inositol triphosphate receptor 3, the expression level being quantified by highly stringent hybridization of RNA obtained from the wound tissue sample to a probe that is complementary to SEQ ID NO:1, SEQ ID NO:3 or SEQ ID NO:5, wherein the only gene expression levels quantified in the method are one or more of angiotensin II receptor, interleukin I receptor antagonist and inositol triphosphate receptor 3, and wherein the expression level of inositol triphosphate receptor 3 is quantified; andcomparing the expression level of the angiotensin II receptor, interleukin I receptor antagonist or inositol triphosphate receptor 3 of the wound tissue sample with another expression level of angiotensin II receptor, interleukin I receptor antagonist or inositol triphosphate receptor 3 in tissue of the same type from the mammalian subject.