$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[미국특허] Isothermal nucleic acid amplification methods and compositions 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12P-019/34
출원번호 US-0370534 (2009-02-12)
등록번호 US8034568 (2011-09-27)
발명자 / 주소
  • Kurn, Nurith
  • Wang, Shenglong
출원인 / 주소
  • NuGEN Technologies, Inc.
대리인 / 주소
    Wilson Sonsini Goodrich & Rosati
인용정보 피인용 횟수 : 13  인용 특허 : 173

초록

Methods and compositions are provided related to the amplification of target polynucleotide sequences as well as total RNA and total DNA amplification. In some embodiments, the methods and compositions also allow for the immobilization and capture of target polynucleotides with defined 3′ and or 5′

대표청구항

What is claimed is: 1. A method for creating a partial RNA-DNA heteroduplex comprising:a) providing a template nucleic acid in a reaction mixture;b) adding a first primer to said reaction mixture and generating a first primer extension product with said first primer;c) adding a second primer that is

이 특허에 인용된 특허 (173) 인용/피인용 타임라인 분석

  1. Bar-Tana Jacob (Jerusalem ILX) Migron Yoelit (Jerusalem ILX) Blum Jochanan (Jerusalem ILX) Dreckmann Bruno (Mannheim DEX) Pill Johannes (Leimen DEX), a 상세보기
  • Bekkaoui Faouzi,CAX ; Modrusan Zora D.,CAX ; Piche Isabelle A.,CAX ; Duck Peter D.,CAX ; Cloney Lynn P.,CAX ; Wong Alfred C. K.,CAX, Additives for use in cycling probe reactions.
  • Kurn,Nurith, Amplification of RNA sequences using composite RNA-DNA primers and strand displacement.
  • Marshall Ronald L. (Zion IL) Carrino John J. (Gurnee IL) Sustachek Joann C. (Racine WI), Amplification of RNA sequences using the ligase chain reaction.
  • Collier David Nash ; Ebersole Richard Calvin ; Hatfield Tina Marie ; Hendrickson Edwin R. ; Moran John Richard, Amplification of assay reporters by nucleic acid replication.
  • Schuster David M. (Poolesville MD) Berninger Mark S. (Gaithersburg MD), Amplification of nucleic acid molecules.
  • Hartley James L. (Frederick MD), Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers.
  • Hartley James L. (Frederick MD) Berninger Mark S. (Gaithersburg MD), Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers.
  • Birkenmeyer Larry G. (Chicago IL) Carrino John J. (Gurnee IL) Dille Bruce J. (Antioch IL) Hu Hsiang-Yun (Libertyville IL) Kratochvil Jon D. (Kenosha WI) Laffler Thomas G. (Libertyville IL) Marshall R, Amplification of target nucleic acids using gap filling ligase chain reaction.
  • Chee Mark ; Cronin Maureen T. ; Fodor Stephen P. A. ; Huang Xiaohua X. ; Hubbell Earl A. ; Lipshutz Robert J. ; Lobban Peter E. ; Morris MacDonald S. ; Sheldon Edward L., Arrays of nucleic acid probes on biological chips.
  • Long John D. (Scarborough CAX), Article dispenser for use with continuous strip of articles.
  • Ullman Edwin F. (Atherton CA) Kirakossian Hrair (San Jose CA) Pease John S. (Los Altos CA) Daniloff Yuri (Mountain View CA) Wagner Daniel B. (Sunnyvale CA), Assay method utilizing photoactivated chemiluminescent label.
  • Kramer Fred R. (Bronx NY) Miele Eleanor A. (Brooklyn NY) Mills Donald R. (Englewood NJ), Autocatalytic replication of recombinant RNA.
  • Cashman Daniel P., Blocked-polymerase polynucleotide immunoassay method and kit.
  • Wetmur James G. ; Quartin Robin S. ; Engelhardt Dean L., Branch migration of nucleotides.
  • Guillou-Bonnici Fran.cedilla.oise,FRX ; Cleuziat Philippe,FRX ; Mallet Fran.cedilla.ois,FRX ; Levasseur Pierre ; McAllister William, Chimera oligonucleotide and its utilization for obtaining transcripts of a nucleic acid.
  • Rossi John J. ; Taylor Nerida, Chimeric DNA-RNA catalytic sequences.
  • Pinkel Daniel ; Gray Joe W. ; Kallioniemi Anne,FIX ; Kallioniemi Olli-Pekka,FIX ; Waldman Frederic, Comparative genomic hybridization.
  • Duck Peter D.,CAX ; Bekkaoui Faouzi,CAX ; Crosby William L.,CAX ; Tullis Richard H., Compositions and methods for detecting target nucleic acid sequences utilizing adjacent sequence-enzyme molecules.
  • Ruano Gualberto (New Haven CT), Coupled amplification and sequencing of DNA.
  • Duck Peter (Burnaby CAX) McNevin John (Vancouver CAX), Cycling probe cleavage detection of nucleic acid sequences.
  • Stemmer Willem P. C. ; Crameri Andreas, DNA mutagenesis by random fragmentation and reassembly.
  • Tyagi Sanjay ; Kramer Fred R. ; Lizardi Paul M.,MXX, Detectably labeled dual conformation oligonucleotide probes, assays and kits.
  • Roll Bruce (Honolulu HI), Detection and identification of enteric pathogens.
  • Emanuel Peter A. ; Valdes James J. ; Eldefrawi Mohyee E. ; Burans James P., Detection of botulinum toxin.
  • Barany Francis ; Lubin Matthew, Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions.
  • Ullman Edwin F. ; Western Linda M. ; Rose Samuel J., Detection of nucleic acids by formation of template-dependent product.
  • Allman Derryl D. J. (Colorado Springs CO), Electronic device with a spin-on glass dielectric layer.
  • Malek Lawrence T. (Brampton CAX) Davey Cheryl (Toronto CAX) Henderson Graham (Mississauga CAX) Sooknanan Roy (Toronto CAX), Enhanced nucleic acid amplification process.
  • Kacian Daniel Louis ; Dattagupta Nanibhushan ; Lackey David Bruce, Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers.
  • Dattagupta Nanibhushan ; Kacian Daniel L. ; Lackey David Bruce, Enzymatic synthesis of oligonucleotides using digestible templates.
  • Lockhart David J. ; Brown Eugene L. ; Wong Gordon G. ; Chee Mark S. ; Gingeras Thomas R., Expression monitoring by hybridization to high density oligonucleotide arrays.
  • Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
  • Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
  • Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
  • Heller Michael J. (Poway CA) Jablonski Edward J. (San Diego CA), Fluorescent stokes shift probes for polynucleotide hybridization.
  • Furness, L. Michael; Buchbinder, Jenny L., Genes expressed in C3A liver cell cultures treated with steroids.
  • Kurn,Nurith; Wang,Shenglong, Global amplification using random priming by a composite primer.
  • Timms Kathy Lynn, Glycoprotein for use in determining endometrial receptivity.
  • Erlich Henry A. (Oakland CA), HLA typing method and cDNA probes used therein.
  • Hall Kathleen S. ; Smith Lloyd H., High throughput papilloma virus in vitro infectivity assay.
  • Hepp Jozsef ; Lengyel Zsolt ; Pande Rajiv, Homogeneous diagnostic assay method utilizing simultaneous target and signal amplification.
  • Winger Edward E. ; Hargrove David E., Homogeneous nucleotide amplification and assay.
  • Heller Michael J. (Encinitas CA), Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to donor energy transfe.
  • Arnold ; Jr. Lyle J. ; Nelson Norman C., Hybridization protection assay.
  • Sano Takeshi (Boston MA) Cantor Charles R. (Boston MA) Smith Cassandra L. (Boston MA), Immuno-polymerase chain reaction system for antigen detection.
  • Agrawal Sudhir, Inverted chimeric and hybrid oligonucleotides.
  • Hoser, Mark Jay; Kurtis, Christian, Isothermal amplification of nucleic acids.
  • Enoki,Tatsuji; Sagawa,Hiroaki; Kato,Ikunoshin, Isothermal chimeric primer nucleic acid amplification methods using blocking oglionucleotide.
  • Kacian Daniel Louis ; Fultz Timothy J., Kits for nucleic acid sequence amplification methods.
  • Nikiforov Theo (Baltimore MD) Karn Jonathan (Little Shelord GBX) Goelet Philip (Cockeysville MD), Ligase/polymerase mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis.
  • Wallace Robert Bruce, Linked linear amplification of nucleic acids.
  • Rothberg Jonathan Marc ; Deem Michael W. ; Simpson John W., Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing.
  • Trulson Mark (Santa Clara CA) Stern David (Mountain View CA) Fiekowsky Peter (Los Altos CA) Rava Richard (Palo Alto CA) Walton Ian (Menlo Park CA) Fodor Stephen P. A. (Palo Alto CA), Method and apparatus for imaging a sample on a device.
  • Chetverin Alexander B. (Moskovskaya oblast Puschino ; mikroraion AB ; 24 ; kv.238 RUX) Chetverina Helena V. (Moskovskaya oblast Puschino ; mikroraion AB ; 24 ; kv.238 RUX), Method for amplification of nucleic acids in solid media.
  • Mukai, Hiroyuki; Sagawa, Hiroaki; Uemori, Takashi; Yamamoto, Junko; Tomono, Jun; Kobayashi, Eiji; Enoki, Tatsuji; Takeda, Osamu; Miyake, Kazue; Sato, Yoshimi; Moriyama, Mariko; Sawaragi, Haruhisa; Ha, Method for amplifying nucleic acid sequence.
  • Cleuziat Philippe,FRX ; Mandrand Bernard,FRX, Method for amplifying nucleic acid sequences by strand displacement using DNA/RNA chimeric primers.
  • Saiki Randall K. (Richmond CA) Erlich Henry A. (Oakland CA), Method for detection of polymorphic restriction sites and nucleic acid sequences.
  • Ullman Edwin F. (Atherton CA) Goodman Thomas C. (Mountain View CA) Stull Paul D. (Mountain View CA), Method for detection of specific nucleic acid sequences.
  • Goelet Philip ; Knapp Michael R. ; Anderson Stephen, Method for determining nucleotide identity through extension of immobilized primer.
  • Goelet Philip ; Knapp Michael R. ; Anderson Stephen, Method for determining nucleotide identity through primer extension.
  • Soderlund Hans E.,FIX ; Syvanen Anne-Christine,FIX, Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators.
  • Laney Maureen ; Chen Yan ; Ullman Edwin F. ; Hahnenberger Karen M., Method for introducing defined sequences at the 3' end of polynucleotides.
  • Laney Maureen (Palo Alto CA) Chen Yan (Palo Alto CA) Ullman Edwin F. (Atherton CA) Hahnenberger Karen M. (Cupertino CA), Method for introducing defined sequences at the 3\end of polynucleotides.
  • Shannon Karen W., Method for linear mRNA amplification.
  • Cleuziat Philippe,FRX ; Guillou-Bonnici Francoise,FRX ; Mallet Francois,FRX ; Levasseur Pierre,FRX, Method for nucleic acid amplification by transcription using displacement, and reagents and kit therefor.
  • Cleuziat Philippe,FRX ; Guillou-Bonnici Francoise,FRX ; Mallet Francois,FRX ; Levasseur Pierre,FRX, Method for nucleic acid amplification by transcription using displacement, and reagents and kit therefor.
  • Kievits Tim (Vught NLX) Lens Peter Franklin (Den Bosch NLX) Adriaanse Henriette Maria Aleida (Boxmeer NLX), Method for nucleic acid amplification using inosine triphosphates to partially replace guanosine triphosphates in the sy.
  • 100 ; Takagaki et al., Method for performing amplification of nucleic acid on supports.
  • Adams Christopher P. (Winter Hill MA) Kron Stephen Joseph (Boston MA), Method for performing amplification of nucleic acid with two primers bound to a single solid support.
  • Rose Samuel (Mountain View CA) Western Linda M. (Mountain View CA) Becker Martin (Palo Alto CA) Ullman Edwin F. (Atherton CA), Method for producing a polynucleotide for use in single primer amplification.
  • Richards Rodney M. (Louisville CO) Jones Theodore (Lakewood CO) Snitman David L. (Boulder CO) Brown Gregory S. (Boulder CO), Method for reducing carryover contamination in an amplification procedure.
  • Richards Rodney M. ; Jones Theodore ; Brown Gregory S., Method for reducing carryover contamination in an amplification procedure.
  • Richards Rodney M. ; Jones Theodore ; Snitman David L. ; Brown Gregory S., Method for reducing carryover contamination in an amplification procedure.
  • Bajaj S. Paul, Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension.
  • Kilger Christian,DEX ; Paabo Svante,DEX, Method for the direct, exponential amplification and sequencing of DNA molecules and its application.
  • Wang Bruce ; Chung Alicia, Method for unbiased mRNA amplification.
  • Dean, Frank B.; Lasken, Roger S., Method of amplifying whole genomes without subjecting the genome to denaturing conditions.
  • Eberwine James ; Rodgers Lori, Method of detecting protein by immuno RNA.
  • Macevicz Stephen C., Method of detecting the presence or absence of a plurality of target sequences using oligonucleotide tags.
  • Chang, Chu An; Chen, Shiaw Min, Method of generating long nucleic acid molecules of defined sequence.
  • Ruoslahti Erkki ; Pasqualini Renata, Method of identifying molecules that home to a selected organ in vivo.
  • Wolfgang Dietmaier DE; Josef Ruschoff DE, Method of primer-extension preamplification PCR.
  • Eyal Nurit,ILX ; Navot Nir,ILX, Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits t.
  • Drmanac Radoje, Methods and apparatus for DNA sequencing and DNA identification.
  • Kurn,Nurith, Methods and compositions for amplification of RNA sequences.
  • Kurn, Nurith, Methods and compositions for amplification of RNA sequences using RNA-DNA composite primers.
  • Fox Donna K. ; Chatterjee Deb K., Methods and compositions for cloning nucleic acid molecules.
  • Chenchik Alex ; Zhu York ; Diatchenko Luda ; Siebert Paul, Methods and compositions for full-length cDNA Cloning using a template-switching oligonucleotide.
  • Chenchik Alex ; Zhu York ; Diatchenko Luda ; Siebert Paul, Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end.
  • Kurn, Nurith, Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof.
  • Kurn, Nurith, Methods and compositions for linear isothermal amplification of polynucleotide sequences.
  • Kurn Nurith, Methods and compositions for linear isothermal amplification of polynucleotide sequences, using a RNA-DNA composite primer.
  • Phillip A. Patten ; Willem P. C. Stemmer, Methods and compositions for polypeptide engineering.
  • Kurn, Nurith, Methods and compositions for transcription-based nucleic acid amplification.
  • Kurn,Nurith, Methods and compositions for transcription-based nucleic acid amplification.
  • Kurn,Nurith, Methods and kits for amplification of RNA sequences using composite primers.
  • Kurn, Nurith, Methods and probes for detection and/or quantification of nucleic acid sequences.
  • Duck Peter (Ottawa CAX) Bender Robert (Ottawa CAX), Methods for detecting nucleic acid sequences.
  • Kurn,Nurith; Wang,Martin Junhong, Methods for generating double stranded DNA comprising a 3' single stranded portion and uses of these complexes for recombination.
  • Stemmer Willem P. C. ; Crameri Andreas, Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
  • Fisher Mary E. (Oakland CA) Watson Robert M. (Berkeley CA), Methods for in-solution quenching of fluorescently labeled oligonucleotide probes.
  • Laney Maureen (Palo Alto CA) Chen Yan (Palo Alto CA) Ullman Edwin F. (Atherton CA) Hahnenberger Karen M. (Cupertino CA), Methods for producing a single stranded polydeoxynucleotide having two different defined sequences and kits.
  • Willem P.C. Stemmer, Methods for recombining nucleic acids.
  • McDonough Sherrol H. ; Kacian Daniel L. ; Dattagupta Nanibhushan ; McAllister Diane L. ; Hammond Philip W. ; Ryder Thomas B., Methods of amplifying nucleic acids using promoter-containing primer sequence.
  • Schlossmacher Michael G.,ATX ; Selkoe Dennis J., Methods of screening for compounds which inhibit soluble .beta.-amyloid peptide production.
  • Cao, Yanxiang; Hsie, Linda, Methods of small sample amplification.
  • Pardee Arthur B. (Brookline MA) Liang Peng (Watertown MA), Methods to clone polyA mRNA.
  • Johnson Martin D., Modified primer extension reactions for polynucleotide sequence detection.
  • Van Gelder Russell N. ; Von Zastrow Mark E. ; Barchas Jack D. ; Eberwine James D., Multi-genes expression profile.
  • Lizardi Paul M., Multiple displacement amplification.
  • Lizardi Paul M., Multiple displacement amplification.
  • Lizardi, Paul M., Multiple displacement amplification.
  • Davey Cheryl (Toronto CAX) Malek Lawrence T. (Brampton CAX), Nucleic acid amplification process.
  • Davey Cheryl (Toronto CAX) Malek Lawrence T. (Brampton CAX), Nucleic acid amplification process.
  • Rose Samuel (3401 Hillview Ave. ; P.O. Box 10850 Palo Alto CA 94303) Goodman Thomas C. (3401 Hillview Ave. ; P.O. Box 10850 Palo Alto CA 94303) Western Linda M. (3401 Hillview Ave. ; P.O. Box 10850 P, Nucleic acid amplification using single primer.
  • Gerdes John C. ; Marmaro Jeffrey M. ; Roehl Christopher A., Nucleic acid archiving.
  • Duck Peter (Ottawa CAX) Bender Robert (Ottawa CAX) Crosby William (Saskatoon CAX) Robertson John G. (L\Ange Gardien CAX), Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences.
  • Walder Joseph A. (Iowa City IA) Walder Roxanne Y. (Iowa City IA), Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled.
  • Gold Larry (Boulder CO) Jayasena Sumedha D. (Boulder CO), Nucleic acid ligand inhibitors to DNA polymerases.
  • Kacian Daniel L. (San Diego CA) McAllister Diane L. (San Diego CA) McDonough Sherrol H. (San Diego CA) Dattagupta Nanibhushan (San Diego CA), Nucleic acid sequence amplification method, composition and kit.
  • Kacian Daniel L. (San Diego CA) Fultz Timothy J. (Vista CA), Nucleic acid sequence amplification methods.
  • Kacian Daniel L. (San Diego CA) Fultz Timothy J. (Vista CA), Nucleic acid sequence amplification methods.
  • Kacian Daniel Louis ; Fultz Timothy J., Nucleic acid sequence amplification methods.
  • Walker George T. (Chapel Hill NC) Little Michael C. (Raleigh NC) Nadeau James G. (Durham NC), Nucleic acid target generation.
  • Crameri Andreas,CHX ; Stemmer Willem P.C. ; Minshull Jeremy ; Bass Steven H. ; Welch Mark ; Ness Jon E. ; Gustafsson Claes ; Patten Phillip A., Oligonucleotide mediated nucleic acid recombination.
  • Monforte Joseph Albert ; Becker Christopher Hank ; Shaler Thomas Andrew ; Pollart Daniel Joseph, Oligonucleotide sizing using cleavable primers.
  • Monforte Joseph Albert (Berkeley CA) Becker Christopher Hank (Menlo Park CA) Shaler Thomas Andrew (San Francisco CA) Pollart Daniel Joseph (Menlo Park CA), Oligonucleotide sizing using immobilized cleavable primers.
  • Zhao Ningyue ; Wurst Helmut, One step RT-PCR methods, enzyme mixes and kits for use in practicing the same.
  • Kevin A. Jarrell ; Vincent W. Coljee ; William Donahue ; Svetlana Mikheeva, Ordered gene assembly.
  • Chirikjian Jack G. ; Collier G. Bruce, Oscillating signal amplifier for nucleic acid detection.
  • Dodge, Anthony H.; Meng, Yu-Ju G.; Sims, Paul W.; Sinicropi, Dominick V.; Williams, P. Mickey; Wong, Wai Lee, PCR assay.
  • Pease John S. ; Kirakossian Hrair ; Wagner Daniel B. ; Ullman Edwin F., Photoactivatable chemiluminescent matrices.
  • Brenner Sydney,GB2, Polynucleotide detection by isothermal amplification using cleavable oligonucleotides.
  • Fujii Tadaaki,JPX ; Yoda Toshiro,JPX ; Tomioka Eiichi,JPX, Power steering apparatus with pump driven by pulse width modulated controlled, brushless d.c. electric motor.
  • Reeve Michael Alan,GBX ; Howe Roland Paul,GBX ; Schwarz Terek,GBX, Primer extension mass spectroscopy nucleic acid sequencing method.
  • Monforte, Joseph Albert; Becker, Christopher Hank; Shaler, Thomas Andrew; Pollart, Daniel Joseph, Primers useful for sizing nucleic acids.
  • Mathies Richard A. (El Cerrito CA) Glazer Alexander (Orinda CA) Ju Jingyue (Berkeley CA), Probes labelled with energy transfer coupled dyes.
  • Van Gelder Russell N. (2200 Divot Dr. Crystal Lake MD 63131) Von Zastrow Mark E. (11570 Buena Vista Dr. Los Altos CA 94022) Barchas Jack D. (1900 Rittenhouse Sq. #18A Philadelphia PA 19103) Eberwine , Process for amplifying a target polynucleotide sequence using a single primer-promoter complex.
  • Ash Carlton E. (Bartlesville OK), Process for preparing arylene sulfide polymers with halo benzene containing deactivating group.
  • Caruthers Marvin H. (Boulder CO) Matteucci Mark D. (Boulder CO), Process for preparing polynucleotides.
  • Tsugunori Notomi JP; Tetsu Hase JP, Process for synthesizing nucleic acid.
  • Van Gelder Russell N. ; Von Zastrow Mark E. ; Barchas Jack D. ; Eberwine James H., Processes for genetic manipulations using promoters.
  • Berninger Mark S. (Gaithersburg) Schuster David M. (Poolesville) Rashtchian Ayoub (Gaithersburg MD), Promoter ligation activated transcription amplification of nucleic acid sequences.
  • Royer Catherine A., Quantitative detection of macromolecules with fluorescent oligonucleotides.
  • Linsley Peter S. ; Schelter Janell M., RNA amplification method.
  • Smith Steven S. ; Kaplan Bruce E., RNA-DNA hybrid molecules of nucleic acid.
  • Paddock Gary V. (Mount Pleasant SC), Recombinant cDNA construction method and hybrid nucleotides useful in cloning.
  • Sano Takeshi (Albany CA) Cantor Charles R. (Berkeley CA), Recombinant streptavidin-protein chimeras useful for conjugation of molecules in the immune system.
  • George M. Church ; Rob Mitra, Replica amplification of nucleic acid arrays.
  • Lizardi Paul M.,MXX, Rolling circle replication reporter systems.
  • Lizardi Paul M.,MXX, Rolling circle replication reporter systems.
  • Lizardi Paul M.,MXX, Rolling circle replication reporter systems.
  • Burg James L. (Foster City CA) Pouletty Philippe J. (Menlo Park CA) Boothroyd John C. (Palo Alto CA), Selective amplification of target polynucleotide sequences.
  • Burg James Lawrence ; Pouletty Philippe Jacques ; Boothroyd John Charles, Selective amplification of target polynucleotide sequences.
  • Martinelli Richard A. ; Carroll ; III Eddie, Sensitive immunoassays utilizing antibody conjugates with replicable DNA templates.
  • Bohlander Stefan K., Sequence independent amplification of DNA.
  • Lizardi Paul M. ; Huang Xiaohua, Single molecule analysis target-mediated ligation of bipartite primers.
  • McKelvey Harold E. (Plymouth MI), Spandrel units.
  • Shen Nancy L. (San Diego CA) Kacian Daniel L. (San Diego CA) Putnam James G. (San Diego CA) Davis William M. (San Diego CA), Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification.
  • Walker George T. (Chapel Hill NC), Strand displacement amplification.
  • Walker George Terrance, Strand displacement amplification.
  • Fraiser Melinda S. (Durham NC) Spargo Catherine A. (Cary NC) Walker George Terrance (Chapel Hill NC) Van Cleve Mark (San Jose CA) Wright David James (Chapel Hill NC) Little Michael C. (Baltimore MD), Strand displacement amplification using thermophilic enzymes.
  • Hampson Ian N. (Heywood GBX) Pope Lynne (Heywood GBX) Butler John (Stockport GBX), Subtraction hybridization.
  • Malek Lawrence T.,CAX ; Sooknanan Roy R.,CAX, Subtractive amplification.
  • Lockhart David J. (Santa Clara CA) Vetter Dirk (Freiburg DEX) Diggelmann Martin (Niederdorf CHX), Surface-bound, unimolecular, double-stranded DNA.
  • Fodor Stephen P. A. (Palo Alto CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Stryer Lubert (Stanford CA), Synthesis and screening of immobilized oligonucleotide arrays.
  • Pardee Arthur B. ; Liang Peng, System for comparing levels or amounts of mRNAs.
  • Burmer Glenna C., Tagged ligand arrays for identifying target-ligand interactions.
  • Malek Lawrence (Brampton CAX) Sooknanan Roy (Toronto CAX), Terminal repeat amplification method.
  • Mamone Joseph A. ; Davis Maria ; Sha Dan, Thermostable DNA polymerase from Thermoanaerobacter thermohydrosulfuricus.
  • Lizardi Paul M.,MXX ; Caplan Michael, Unimolecular segment amplification and sequencing.
  • Dower William J. ; Gates Christian M. ; Heinkel Gregory L. ; Lalonde Guy ; Mattheakis Larry C. ; Paddon Christopher J. ; Schatz Peter J., Use of modified tethers in screening compound libraries.
  • 이 특허를 인용한 특허 (13) 인용/피인용 타임라인 분석

    1. Armour, Christopher; Amorese, Doug; Li, Bin; Kurn, Nurith, Compositions and methods for negative selection of non-desired nucleic acid sequences.
    2. Amorese, Doug; Armour, Chris; Kurn, Nurith, Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation.
    3. Amorese, Doug; Armour, Chris; Kurn, Nurith, Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library regeneration.
    4. Kurn, Nurith, Compositions for amplification of RNA sequences using composite primers.
    5. Kurn, Nurith; Wang, Shenglong, Global amplification using a randomly primed composite primer.
    6. Kurn, Nurith; Wang, Shenglong, Global amplification using a randomly primed composite primer.
    7. Kurn, Nurith; Wang, Shenglong, Nucleic acid amplification procedure using RNA and DNA composite primers.
    8. Rigatti, Roberto; Gormley, Niall Anthony; Eckhardt, Allen E.; Boutell, Jonathan Mark, Polynucleotide modification on solid support.
    9. Rigatti, Roberto; Gormley, Niall Anthony; Eckhardt, Allen E.; Boutell, Jonathan Mark, Polynucleotide modification on solid support.
    10. Kankia, Besik, Primers and methods for nucleic acid amplification.
    11. Kankia, Besik, Primers and methods for nucleic acid amplification.
    12. Schroeder, Benjamin G., Reduced representation bisulfite sequencing with diversity adaptors.
    13. Amorese, Doug; Schroeder, Benjamin G.; Scolnick, Jonathan, Sequential sequencing.

    활용도 분석정보

    상세보기
    다운로드
    내보내기

    활용도 Top5 특허

    해당 특허가 속한 카테고리에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
    더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

    섹션별 컨텐츠 바로가기

    AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

    AI-Helper 아이콘
    AI-Helper
    안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
    ※ AI-Helper는 부적절한 답변을 할 수 있습니다.

    선택된 텍스트

    맨위로