[특허]Diagnostic testing process

[미국특허] Diagnostic testing process 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/543
출원번호	US-0874675 (2010-09-02)
등록번호	US8067246 (2011-11-16)
우선권정보	AU-2001-R 9451(2001-12-12)
발명자 / 주소	Marlborough, David Ian Sloane, Andrew John Cole, Robert Alan Hunter, William Samuel
출원인 / 주소	Tyrian Diagnostics Limited
대리인 / 주소	Hamilton, Brook, Smith & Reynolds, P.C.
인용정보	피인용 횟수 : 6 인용 특허 : 31

초록 ▼

A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analyzed (typically for the presence of a particular protein), and a detection analyte (typically one or more antibodies bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre-incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus o permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.

대표청구항 ▼

What is claimed is: 1. A flow-through assay device comprising:a cassette consisting of a first member and a second member, wherein the first member defines a well having an upper surface and a lower surface wherein the upper surface of said well has an opening and the lower surface of said well is defined by a porous reaction membrane to which is bound one or more capture analytes and the second member consists of a body of absorbent material disposed below the lower surface of the first member;a removable chamber spaced above the first member of the cassette said removable chamber having side walls and a base defined by a membrane; andmeans for supporting the removable chamber above the first member in a first position and a second position, wherein the first position provides sufficient spacing between the chamber and the first member so as to not permit fluid transfer from the chamber to the body of absorbent material, and wherein the second position provides for contact between the membrane of the removable chamber and the first member to thereby permit fluid transfer from the removable chamber to the body of absorbent material.

이 특허에 인용된 특허 (31) 인용/피인용 타임라인 분석

Chu Albert E., Analytical device for membrane-based assays.
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Parker James E. (Long Beach CA), Antibody testing system with removable air gap.
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Greene Richard A. (Westford MA) Kasila Patricia A. (Windham NH), Assay device and immunoassay.
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Tom Henry K. (La Honda CA) Rowley Gerald L. (Cupertino CA), Concentrating zone method in heterogeneous immunoassays.
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Wong Sie Ting ; Hiltibran Robert G. ; Huang Tung-Ming ; Calfin Brenda B. ; Pope Mark R. ; Schapira Thomas G. ; Shain Eric B. ; Young Douglas F., Diagnostic assay for a sample of biological fluid.
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Marlborough, David Ian; Sloane, Andrew John; Cole, Robert Alan; Hunter, William Samuel, Diagnostic testing process.
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Cole,Robert Alan; Sloane,Andrew John; Hunter,William Samuel, Diagnostic testing process and apparatus.
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Chu Albert E. (140 Roblar Ave. Hillsborough CA 94010) Chun Peter K. (2566 Adams Ct. ; So. South San Francisco CA 94080) Yeung Siu Chin C. (36 Ottawa St. San Mateo CA 94401), Elongated membrane flow-through diagnostic device and method.
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Clark Phillip (Malden MA), Flow through assay apparatus and process.
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Kalra Krishan L. (Moraga CA) Pawlak Katarzyna (Oakland CA) Moon Patricia A. (San Ramon CA) French Larry D. (Oakland CA), Immunoassay test device and method.
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Zuk Robert F. (Menlo Park CA) Litman David J. (Mountain View CA), Immunochromatographic assay with support having bound “MIP”and second enzyme.
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Wong Siu-Yin ; Chen Fon-Chiu Mia ; Fan Eugene, Immunodiagnostic device.
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Gordon Julian (Lake Bluff IL) Pugh Charles S. G. (Kenosha WI), Lateral flow chromatographic binding assay device.
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Hudak, Robert Thomas; Bautista, Lorraine, Line test device and methods of use.
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Poissant Philip (Toronto CAX) Lea Peter (Toronto CAX), Medical test kit.
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Valkirs Gunars E. (San Marcos CA) Owen Newton C. (Encinitas CA) Levinson Philip A. (San Diego CA), Method and apparatus for immunoassays.
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Kawakami Masaya (Sagamihara JPX) Seto Susumu (Yokohama JPX) Tei Seiken (Yokohama JPX), Method of determining viable microbial cell count.
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Brooks ; Jr. Houston G. (Somerset NJ) Chang Chi-Deu (Bridgewater NJ) Chakraborty Utpal R. (Flemington NJ) Graham ; Jr. Henry A. (Annandale NJ) Hollenbeck ; Jr. Lloyd L. (Flemington NJ) Lawler Sharon , Method of producing a metal sol reagent containing colloidal metal particles.
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Litman David J. (Palo Alto CA) Ullman Edwin F. (Atherton CA), Preferential signal production on a surface in immunoassays.
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Mansour James David, Quality control procedure for membrane flow-through diagnostic assay devices.
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Maggio Edward T. (Redwood City CA) Wife Richard L. (Sittingbourne CA GB2) Ullman Edwin F. (Atherton CA), Reagents and method employing channeling.
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Devaney ; Jr. Mark J. (Rochester NY) Wannenwetsch Edward H. (Rochester NY), Sliding test device for assays.
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Brown William E. (Grayslake IL) Clemens John M. (Gurnee IL) Devereaux Sharon M. (Gurnee IL) Hofler John G. (Ingleside IL) Knigge Kevin M. (Wheeling IL) Safford Sarah E. (Libertyville IL), Solid phase analytical device and method for using same.
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Noppe Marcus Joannes Maria,BEX ; Garrevoet Theo Cesar,BEX, Solid phase assay for use with a physical developer.
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Brown ; III William E. (Grayslake IL) Safford Sarah E. (Libertyville IL) Clemens John M. (Gurnee IL), Solid-phase analytical device and method for using same.
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Brown ; III William E. (Grayslake IL) Safford Sarah E. (Libertyville IL) Clemens John M. (Gurnee IL), Solid-phase analytical device and method for using same.
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Cole Francis X. (Stowe MA) Edwards James H. (Winchester MA) Hendrick Clifford L. (Boxboro MA) VanVoorhis Deborah M. (Watertown MA), Test device.
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Vonk Glenn P. (Fuquay-Varina NC), Test device including flow control means.
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Litman David J. (Cupertino CA) Ullman Edwin F. (Atherton CA), Test strip kits in immunoassays and compositions therein.
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Hossom Miles G. (Duluth GA) Jacob Dinesh A. (Girton GBX), Transverse flow diagnostic device.
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Hossom Miles G. (Duluth GA), Transverse flow diagnostic kit.
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이 특허를 인용한 특허 (6) 인용/피인용 타임라인 분석

Bermudes, David Gordon, Compositions and methods for determining successful immunization by one or more vaccines.
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Horiuchi, Tsutomu; Miura, Toru; Iwasaki, Yuzuru; Takahashi, Jyunichi; Hayashi, Katsuyoshi; Haga, Tsuneyuki; Seyama, Michiko; Camou, Serge, Flow cell and method for manufacturing the same.
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Withrow, III, Edward W.; Gorlach, Jorn, Flow through testing system with pressure indicator.
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Azizoglu, Reha O.; Bresolin, Stefano; Calderwood, David A.; Cheek, Robert L.; Drach, Joy Parr; Groelke, John; Heineck, Tobias M.; Hockett, Mitchell; Newcomb, David; Olsen, Duane; Paul, Chris; Pollard, Jasper N.; Rodriguez, Rodolfo R.; Young, Demetris, Rapid detection of analytes in liquid samples.
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Rodriguez, Rodolfo R.; Calderwood, David A., Rapid detection of analytes in liquid samples.
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Rodriguez, Rodolfo R.; Calderwood, David A., Rapid detection of analytes in liquid samples.
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IPC	Description
A	생활필수품
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A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Diagnostic testing process 원문보기