초록 ▼

A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the ex

A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

대표청구항 ▼

We claim: 1. A method of determining a tissue state of the tissue of an individual, where “tissue state” comprises any of (i) presence or likelihood of diabetes; (ii) the degree of progression of diabetes; (iii) a change in the presence, likelihood, or progression of diabetes; (iv) a probability of

We claim: 1. A method of determining a tissue state of the tissue of an individual, where “tissue state” comprises any of (i) presence or likelihood of diabetes; (ii) the degree of progression of diabetes; (iii) a change in the presence, likelihood, or progression of diabetes; (iv) a probability of having, not having, developing, or not developing diabetes; (v) the presence, absence, progression, or likelihood of complications from diabetes, in each case based on long-term changes (greater than one month duration) in tissue comprising:a. Illuminating a portion of the tissue of the individual with excitation light;b. Detecting light emitted from the tissue by fluorescence of a chemical within the tissue, where the tissue is not the lens of the eye;c. Determining the tissue state from the detected light and a model relating fluorescence and a tissue state.