Biocompatible controlled release coatings for medical devices and related methods
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/04
A61F-002/00
출원번호
US-0005463
(2004-12-06)
등록번호
US-8088404
(2012-01-03)
발명자
/ 주소
Udipi, Kishore
Cheng, Peiwen
Chen, Mingfei
Lyu, Su-Ping
출원인 / 주소
Medtronic Vasular, Inc.
인용정보
피인용 횟수 :
20인용 특허 :
11
초록▼
Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The pres
Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings.
대표청구항▼
1. A medical device comprising a controlled release coating comprising: a polymer component comprising a terpolymer-co-polymer-homopolymer polymer blend and a drug, wherein the δT for the drug is within ±10 J1/2/cm3/2 of the total solubility parameter δT, for the polymer component; andwherein said t
1. A medical device comprising a controlled release coating comprising: a polymer component comprising a terpolymer-co-polymer-homopolymer polymer blend and a drug, wherein the δT for the drug is within ±10 J1/2/cm3/2 of the total solubility parameter δT, for the polymer component; andwherein said terpolymer comprises monomer subunits consisting essentially of vinyl acetate (VAc), alkyl methacrylate (AMA) and n-vinyl pyrrolidone (NVP), said co-polymer comprises monomer subunits consisting essentially of VAc and AMA, and said homopolymer is polyvinyl pyrrolidone, wherein:the terpolymer has a Tg of 15° C. to 20° C.;the co-polymer has a Tg of 32° C. to 35° C.;the homopolymer has a Tg of 174° C.; andthe polymer blend comprises 20-30% co-polymer, 60-70% terpolymer, and 5-15% homopolymer. 2. The medical device according to claim 1 wherein said relative mole percent concentrations of said monomer subunits in said terpolymer comprises 5-30% (VAc), 40-77% (AMA) and 18-30% (NVP). 3. The medical device according to claim 1 wherein said relative mole percent concentrations of said monomer subunits in said co-polymer comprises 5-70% VAc and 30-95% AMA. 4. The medical device according to claim 1 wherein said alkyl methacrylate is selected from the group consisting of methyl methacrylate, ethyl methacrylate, propyl methacrylate, butyl methacrylate, pentyl methacrylate, and hexyl methacrylate. 5. The medical device according to any one of claim 1 through 4 wherein said δT for the polymer component is approximately 15 to 21. 6. The medical device according to claim 1 wherein said drug is rapamycin, everolimus or ABT-578. 7. The medical device of claim 1 wherein the coating is biocompatible, non-thrombogenic, non-inflammatory, lubricious, and non-bioerodable. 8. A medical device comprising a controlled release coating comprising: a polymer component comprising a terpolymer-co-polymer-homopolymer polymer blend, wherein: the terpolymer and co-polymer each include vinyl acetate;the terpolymer has a low Tg relative to the Tg of the co-polymer and homopolymer;the co-polymer has an intermediate Tg relative to the Tg of the terpolymer and homopolymer;the homopolymer has a high Tg relative to the Tg of the co-polymer and terpolymer;wherein the terpolymer has a Tg of 15° C. to 25° C.; andthe polymer blend comprises 20-30% co-polymer, 60-70% terpolymer, and 5-15% homopolymer; anda drug, wherein the δT for the drug is within ±10 J1/2/cm3/2 of the total solubility parameter δT for the polymer component. 9. The medical device of claim 8 wherein the co-polymer has a Tg of 30° C. to 40° C. 10. The medical device of claim 8 wherein the homopolymer has a Tg of 170° C. to 180° C. 11. The medical device according to claim 8 wherein said coating has a glass transition point (Tg) from approximately −20° C. to 50° C. 12. The medical device according to claim 8 wherein said terpolymer comprises monomer subunits consisting essentially of vinyl acetate (VAc), alkyl methacrylate (AMA) and n-vinyl pyrrolidone (NVP), said co-polymer comprises monomer subunits consisting essentially of VAc and AMA, and said homopolymer is polyvinyl pyrrolidone. 13. The medical device according to claim 12 wherein said relative mole percent concentrations of said monomer subunits in said terpolymer comprises 5-30% (VAc), 40-77% (AMA) and 18-30% (NVP). 14. The medical device according to claim 12 wherein said relative mole percent concentrations of said monomer subunits in said co-polymer comprises 5-70% VAc and 30-95% AMA. 15. The medical device according to claim 12 wherein said alkyl methacrylate is selected from the group consisting of methyl methacrylate, ethyl methacrylate, propyl methacrylate, butyl methacrylate, pentyl methacrylate, and hexyl methacrylate. 16. The medical device according to any one of claim 11 through 15 and claim 8 wherein said δT, for the polymer component is approximately 15 to 21. 17. The medical device according to claim 8 wherein said drug is selected from the group consisting of macrolide antibiotics, FKBP 12 binding compounds, estrogens, chaperone inhibitors, protease inhibitors, protein-tyrosine kinase inhibitors, peroxisome proliferator-activated receptor gamma ligands (PPARγ), hypothemycin, nitric oxide, bisphosphonates, epidermal growth factor inhibitors, antibodies, antibiotics, proteasome inhibitors anti-sense nucleotides and transforming nucleic acids. 18. The medical device according to claim 17 wherein said antibiotic is a FKBP 12 binding compound. 19. The medical device according to claim 18 wherein said FKBP 12 binding compound is a macrolide antibiotic. 20. The medical device according to claim 19 wherein said macrolide antibiotic is rapamycin, everolimus or ABT-578. 21. The medical device of claim 8 wherein the coating is biocompatible, non-thrombogenic, non-inflammatory, lubricious, and non-bioerodable. 22. A vascular stent comprising a structure: said structure comprising a material having a hydrophobic polymer disposed thereon;a controlled release coating over said hydrophobic polymer wherein said controlled release coating comprises a polymer component comprising a terpolymer-co-polymer-homopolymer polymer blend, wherein:the terpolymer and co-polymer each include vinyl acetate;the terpolymer has a low Tg relative to the Tg of the co-polymer and homopolymer;the co-polymer has an intermediate Tg relative to the Tg of the terpolymer and homopolymer;the homopolymer has a high Tg relative to the Tg of the co-polymer and terpolymer;wherein the terpolymer has a Tg of 15° C. to 25° C.; andthe polymer blend comprises 20-30% co-polymer, 60-70% terpolymer, and 5-15% homopolymer; anda bioactive agent, wherein the δT for the bioactive agent is within ±10 J1/2/cm3/2 of the total solubility parameter δT for the polymer component. 23. The vascular stent of claim 22 wherein the co-polymer has a Tg of 30° C. to 40° C. 24. The vascular stent of claim 22 wherein the homopolymer has a Tg of 170° C. to 180° C. 25. The vascular stent according to claim 22 wherein said hydrophobic polymer is parylene. 26. The vascular stent according to claim 22 wherein said terpolymer comprises monomer subunits consisting essentially of vinyl acetate (VAc), alkyl methacrylate (AMA) and n-vinyl pyrrolidone (NVP), said co-polymer comprises monomer subunits consisting essentially of VAc and AMA, and said homopolymer is polyvinyl pyrrolidone. 27. The vascular stent according to claim 26 wherein said relative mole percent concentrations of said monomer subunits in said terpolymer comprises 5-30% (VAc), 40-77% (AMA) and 18-30% (NVP). 28. The vascular stent according to claim 26 wherein said relative mole percent concentrations of said monomer subunits in said co-polymer comprises 5-70% VAc and 30-95% AMA. 29. The vascular stent according to claim 26 wherein said alkyl methacrylate is selected from the group consisting of methyl methacrylate, ethyl methacrylate, propyl methacrylate, butyl methacrylate, pentyl methacrylate, and hexyl methacrylate. 30. The vascular stent according to any one of claim 25 though 29 and claim 22 wherein said δT for the polymer component is approximately 15 to 21. 31. The vascular stent according to claim 22 wherein said bioactive agent is selected from the group consisting of anti-proliferatives including, but not limited to, macrolide antibiotics, FKBP 12 binding compounds, estrogens, chaperone inhibitors, protease inhibitors, protein-tyrosine kinase inhibitors, peroxisome proliferator-activated receptor gamma ligands (PPARγ), hypothemycin, nitric oxide, bisphosphonates, epidermal growth factor inhibitors, antibodies, antibiotics, proteasome inhibitors anti-sense nucleotides and transforming nucleic acids. 32. The vascular stent according to claim 31 wherein said antibiotic is a FKBP 12 binding compound. 33. The vascular stent according to claim 32 wherein said FKBP 12 binding compound is a macrolide antibiotic. 34. The vascular stent according to claim 33 wherein said macrolide antibiotic is rapamycin, everolimus or ABT-578. 35. The vascular stent of claim 22 wherein the coating is biocompatible, non-thrombogenic, non-inflammatory, lubricious, and non-bioerodable. 36. A vascular stent comprising a structure: said structure comprising a material having a hydrophobic polymer disposed thereon;a controlled release coating over said hydrophobic polymer wherein said controlled release coating comprises a polymer component comprising a terpolymer-co-polymer-homopolymer polymer blend, wherein:the terpolymer and co-polymer each include vinyl acetate;wherein the terpolymer has a Tg of 15° C. to 20° C., the co-polymer has a Tg of 32° C. to 35° C., and the homopolymer has a Tg of 174° C.; andthe polymer blend comprises 20-30% co-polymer, 60-70% terpolymer, and 5-15% homopolymer; anda bioactive agent, wherein the δT for the bioactive agent is within ±10 J1/2/cm3/2 of the total solubility parameter δT for the polymer component. 37. A vascular stent comprising a structure: said structure comprising a material having a controlled release coating disposed thereon, said controlled release coating consisting essentially of ABT-578 dispersed in a polymer blend, said polymer blend consisting essentially of a terpolymer, a co-polymer and a homopolymer, wherein:said terpolymer comprises approximately 5 mole-% of vinyl acetate, approximately 77 mole-% of n-hexyl methacrylate, and approximately 18 mole-% of n-vinyl pyrrolidone,said co-polymer consisting essentially of approximately 5 mole-% of vinyl acetate and approximately 95 mole-% of n-butyl methacrylate, andsaid homopolymer consisting essentially of polyvinyl pyrrolidone, andthe polymer blend comprises 20-30% co-polymer, 60-70% terpolymer, and 5-15% homopolymer, andwherein said controlled release coating comprises approximately 35% by weight ABT-578 and approximately 65% by weight of said polymer blend. 38. The vascular stent according to claim 37 wherein said structure is composed of a material selected from the group consisting of metals, polymers and biodegradable polymers.
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