Apparatus and method for preparing platelet rich plasma and concentrates thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01D-033/067
B01D-035/00
B01D-024/32
B04B-003/00
출원번호
US-0917055
(2010-11-01)
등록번호
US-8096422
(2012-01-17)
발명자
/ 주소
Dorian, Randel
Leach, Michael D.
출원인 / 주소
Hanuman LLC
대리인 / 주소
Harness, Dickey
인용정보
피인용 횟수 :
4인용 특허 :
224
초록▼
Disclosed is a separator-concentrator, such as for separating and concentrating platelet-rich-plasma (PRP) from whole blood that is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly and a concentrator assembly. The ce
Disclosed is a separator-concentrator, such as for separating and concentrating platelet-rich-plasma (PRP) from whole blood that is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly and a concentrator assembly. The centrifugal separation assembly comprises a centrifugal drum separator and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate.
대표청구항▼
1. A separator-concentrator comprising: a housing;a platelet-rich-plasma (PRP) separation assembly operable to spin around an axis;a PRP concentration assembly operable to spin around the axis, wherein the PRP concentration assembly has a PRP concentration sump; anda stationary outlet tube substanti
1. A separator-concentrator comprising: a housing;a platelet-rich-plasma (PRP) separation assembly operable to spin around an axis;a PRP concentration assembly operable to spin around the axis, wherein the PRP concentration assembly has a PRP concentration sump; anda stationary outlet tube substantially concentric with the axis extending through the PRP separation assembly to the PRP concentrate sump and secured relative to the housing;wherein the PRP separation assembly is attached to and positioned above the PRP concentration assembly to form a combined separator-concentrator assembly within the housing;wherein the combined separator-concentrator assembly is operable to be rotated about the outlet tube within the housing;wherein the PRP separation assembly further comprises: a separation chamber having an inner wall surface and a sloped floor surface extending from the inner wall surface;a blood inlet into the separation chamber; anda depth filter lining the inner wall surface, wherein the depth filter has pores and passageways that are sized to receive and entrap erythrocytes during centrifuging;wherein the separation chamber further comprises: a top plate; anda balanced distribution of a plurality of separator plates attached to the inner wall surface and sloped floor of the separation chamber, each of the plurality of separator plates extending towards the axis from the inner wall surface so that each of the plurality of separator plates extends from the inner wall surface radially inward to a distance beyond an inner surface of the depth filter and from the sloped floor to a position spaced apart from the top plate;wherein the separation chamber is balanced for substantially vibration-free rotation about the axis. 2. The separator-concentrator of claim 1, wherein the separation chamber further comprises: a valve assembly positioned within the separation chamber to selectively allow a material to move into the PRP concentration assembly. 3. The separator-concentrator of claim 1, wherein the PRP concentration assembly further comprises: a concentration chamber enclosed at least in part by a concentration chamber floor for supporting desiccated beads and a concentration chamber wall extending from the concentration chamber floor, wherein the concentration chamber wall defines at least one opening therethrough;a screen covering the at least one opening, the screen having openings that are sized to retain the desiccated beads in the concentration chamber;an outer wall with a sloped floor secured surrounding at least a portion of the concentration chamber; anda PRP concentration sump defined at a center of the sloped floor. 4. The separator-concentrator of claim 3, wherein the stationary outlet tube extends to the PRP concentration sump and operable to allow withdrawal of a PRP concentrate from the PRP concentration sump through the stationary outlet tube. 5. The separator-concentrator of claim 3, wherein the at least one opening includes a plurality of openings defined by upright screen supports and the screen includes a cylindrical screen supported in the plurality of openings by the upright screen supports. 6. The separator-concentrator of claim 3, further comprising: a stationary bead rake secured to the stationary tube and extending radially outward from the stationary tube;wherein the bead rake has distal ends that are spaced a distance from the concentration chamber wall. 7. The separator-concentrator of claim 6, wherein the bead rake comprises a rake longitudinal body;wherein the rake longitudinal body is secured at a center to the outlet tube;wherein the rake longitudinal body has weakened fracture points near to the stationary tube, whereby the rake longitudinal body fractures when exposed to excessive strain due to contact with desiccated beads that have swelled. 8. A separator-concentrator comprising: a housing;a platelet-rich-plasma (PRP) separation assembly operable to spin around an axis;a PRP concentration assembly operable to spin around the axis, wherein the PRP concentration assembly has a PRP concentration sump;a stationary outlet tube substantially concentric with the axis extending through the PRP separation assembly to the PRP concentrate sump and secured relative to the housing;a concentrator drive coupling connected to a bottom wall of the PRP concentration assembly; anda motor assembly with a motor coupling that engages the concentrator drive coupling;wherein the PRP separation assembly is attached to and positioned above the PRP concentration assembly to form a combined separator-concentrator assembly within the housing;wherein the combined separator-concentrator assembly is operable to be rotated about the outlet tube within the housing. 9. The separator-concentrator of claim 8, wherein the motor assembly comprises a motor control system for timed rotations of the drive coupling during an acceleration period of time, a rapid centrifugal erythrocyte separation period of time, a deceleration period of time, a slow stir concentrating period of time, an acceleration period of time, and a rapid centrifugal PRP concentrate separation period of time. 10. The separator-concentrator of claim 9, further comprising: a motor housing to enclose at least a portion of the motor assembly;wherein the housing is operable to selectively engage the motor housing, wherein the housing is fixed relative to the motor housing during the engagement. 11. A separator-concentrator comprising: a housing;a platelet-rich-plasma (PRP) separation assembly operable to spin around an axis;a PRP concentration assembly operable to spin around the axis, wherein the PRP concentration assembly has a PRP concentration sump;a stationary outlet tube substantially concentric with the axis extending through the PRP separation assembly to the PRP concentrate sump and secured relative to the housing;a valve assembly having a valve face member having a valve face and moveable between an open position and a closed position;a passageway between the PRP separation assembly and the PRP concentration assembly; anda valve seat in a first surface in the PRP separation assembly near the passageway;wherein the PRP separation assembly is attached to and positioned above the PRP concentration assembly to form a combined separator-concentrator assembly within the housing;wherein the combined separator-concentrator assembly is operable to be rotated about the outlet tube within the housing;wherein a seal is formed in the closed position by cooperation of the valve face and the valve seat and the seal is disengaged in the opened position by movement of the valve face away from the valve seat. 12. The separator-concentrator of claim 11, wherein the valve assembly further includes: a plurality of valve operator arms, each valve operator arm having an inflexible portion with a weighted distal end and a flexible proximal portion, each flexible proximal portion secured to the valve face member to move the valve face member thereby moving the valve face to the open position when the plurality of valve operator arms move away from the axis under centrifugal force during a selected rotation of the separator-concentrator assembly around the axis and to bias each of the plurality of valve operator arms towards the axis. 13. The separator-concentrator of claim 12, wherein the PRP separation assembly further comprises: an inner wall surface extending from a floor, wherein at least a portion of the floor defines the valve seat; anda plurality of abutment plates extending from the floor;wherein the valve assembly is substantially contained within the PRP separation assembly;wherein the flexible proximal portions are positioned between at least two of the plurality of abutment plates and at least one of the plurality of the abutment plates contacts at least one of the plurality of valve operator arms to restrain the proximal portion against rotation around the axis when the valve operator arm is positioned near the axis. 14. The separator-concentrator of claim 13, wherein at least one of the plurality of abutment plates has a top edge to support at least one of the plurality of valve operator arms after the valve has moved to the open position thus preventing return movement of the valve operator arm towards the axis and to thereby prevent the valve face member from moving to the closed position. 15. A separator-concentrator comprising: a separator-concentrator assembly housing;a combined separator-concentrator positioned within the separator-concentrator assembly housing, including: a platelet-rich-plasma (PRP) separation assembly operable to spin around an axis having a separation chamber defined by a separation chamber floor and a separation chamber outer wall extending from the separation chamber floor;a PRP concentration assembly operable to spin around the axis having a PRP concentration chamber defined by a concentration floor and a concentration wall extending from the concentration floor, wherein the PRP concentration assembly further includes a PRP concentration sump defined in an exterior floor that is exterior to the PRP concentration chamber, wherein the PRP separation assembly is attached to and positioned above the PRP concentration assembly along the axis;a passageway between the separation chamber and the concentration chamber;an stationary outlet tube substantially concentric with the axis and extending through the PRP separation assembly to the PRP concentration sump and secured to the housing; anda valve assembly positioned substantially within the PRP separation assembly to selectively open to allow a material to move into the PRP concentration chamber;wherein the combined separator-concentrator assembly is operable to be rotated about the outlet tube. 16. The separator-concentrator of claim 15, further comprising: a concentrator material positioned within the PRP concentration chamber. 17. The separator-concentrator of claim 16, wherein the valve assembly includes: a valve face member having a valve face and moveable between an open position and a closed position;a plurality of valve operator arms, each valve operator arm having an inflexible portion with a weighted distal end and a flexible proximal portion, each flexible proximal portion secured to the valve face member to move the valve face member to move the valve face to the open position when the plurality of valve operator arms move away from the axis under centrifugal force during a selected rotation of the separator-concentrator assembly around the axis and bias each of the plurality of valve operator arms towards the axis; anda valve seat in a first surface in the PRP separation assembly near the passageway;wherein a seal is formed in the closed position by cooperation of the valve face and the valve seat and the seal is disengaged in the opened position by movement of the valve face away from the valve seat. 18. The separator-concentrator of claim 17, further comprising: a rake including a body fixed to the stationary outlet tube and tines extending from the body to engage the concentrator material when the PRP concentration assembly spins around the axis. 19. The separator-concentrator of claim 18, further comprising: a motor housing to enclose at least a portion of the motor assembly;the housing operable to selectively engage the motor housing, wherein the housing is fixed relative to the motor housing during the engagement. 20. The separator-concentrator of claim 18, further comprising: a balanced distribution of a plurality of separator plates attached to the inner wall surface and sloped floor of the separation chamber, each of the plurality of separator plates extending towards the axis from the inner wall surface so that each of the plurality of separator plates extends from the inner wall surface radially inward;wherein the separation chamber is balanced for substantially vibration-free rotation about the axis. 21. A separator-concentrator comprising: a separator-concentrator assembly housing;a combined separator-concentrator positioned within the separator-concentrator assembly housing, including: a platelet-rich-plasma (PRP) separation assembly operable to spin around an axis having a separation chamber defined by a separation chamber floor and a separation chamber outer wall extending from the separation chamber floor;a PRP concentration assembly operable to spin around the axis having a PRP concentration chamber defined by a concentration floor and a concentration wall extending from the concentration floor, wherein the PRP concentration assembly further includes a PRP concentration sump defined in an exterior floor that is exterior to the PRP concentration chamber, wherein the PRP separation assembly is attached to and positioned above the PRP concentration assembly along the axis;a passageway between the separation chamber and the concentration chamber;an stationary outlet tube substantially concentric with the axis and extending through the PRP separation assembly to the PRP concentration sump and secured to the housing; anda rake including a body fixed to the stationary outlet tube and the body extending radial outward from the stationary outlet tube and a distance above the concentration floor, the rake further including tines extending from the body towards the concentration floor;wherein the combined separator-concentrator assembly is operable to be rotated about the outlet tube. 22. The separator-concentrator of claim 21, further comprising: a concentrator material positioned within the PRP concentration chamber;wherein the tines are operable to engage the concentrator material when the PRP concentration assembly spins around the axis. 23. The separator-concentrator of claim 22, further comprising: a valve assembly positioned substantially within the PRP separation assembly to selectively open to allow a material to move into the PRP concentration chamber. 24. The separator-concentrator of claim 23, wherein the valve assembly further includes: a valve face member having a valve face and moveable between an open position and a closed position;a plurality of valve operator arms, each valve operator arm having an inflexible portion with a weighted distal end and a flexible proximal portion, each flexible proximal portion secured to the valve face member to move the valve face member to move the valve face to the open position when the plurality of valve operator arms move away from the axis under centrifugal force during a selected rotation of the separator-concentrator assembly around the axis and bias each of the plurality of valve operator arms towards the axis; anda valve seat in a first surface in the PRP separation assembly near the passageway;wherein a seal is formed in the closed position by cooperation of the valve face and the valve seat and the seal is disengaged in the opened position by movement of the valve face away from the valve seat.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (224)
Zine ; Jr. Anthony R. (Corning NY), Access device for centrifugal separation assemblies.
Katz, Adam J.; Llull, Ramon; Futrell, William J.; Hedrick, Marc H.; Benhaim, Prosper; Lorenz, Hermann Peter; Zhu, Min, Adipose-derived stem cells and lattices.
Latham ; Jr. Allen (Jamaica Plain MA) Jorgensen Glen E. (Marlborough MA) Sibinga Theodoor H. S. (Boston MA) Plante Joseph R. (Millis MA) Knapp Tracey E. (Hanover MA), Apheresis apparatus and method.
Latham ; Jr. Allen (Jamaica Plain MA) Jorgensen Glen E. (Marlborough MA) Sibinga Theodoor H. S. (Boston MA) Plante Joseph R. (Millis MA) Knapp Tracey E. (Hanover MA), Apheresis apparatus for separating an intermediate density component from whole blood.
Brimhall Owen D. (West Valley City UT) McLaughlin Thomas J. (Salt Lake City UT) Baker Charles D. (Sandy UT) Peterson Stephen C. (Salt Lake City UT), Apparatus and method for obtaining a rapid hematocrit.
Deniega Jose C. (Lake Forest CA) Duff Daniel H. (Irvine CA) Schoendorfer Donald W. (Santa Ana CA) Miller William R. (Santa Ana CA), Apparatus and methods for generating leukocyte free platelet concentrate.
McEwen James A. (10551 Bamberton Drive Richmond ; British Columbia CAX V7A 1K6) Godolphin William J. (827 West 24th Avenue Vancouver ; British Columbia CAX V5Z-2C2) Bohl Rainer M. (41 East 40th Avenu, Apparatus for collecting blood.
Hlavinka Dennis (Golden CO) Langley Robert (Westminster CO) Taylor Linda (Littleton CO) Walker John C. (Boulder CO), Apparatus for separating particles.
McEwen James A. (Richmond CAX) Godolphin William J. (Vancouver CAX) Bohl Rainer M. (Vancouver CAX) Dance Mark N. (Vancouver CAX) Furse Marty L. (Vancouver CAX) Osborne John C. (Port Coquitlam CAX), Apparatus for separating phases of blood.
Guigan Jean (5 ; rue des Ursulines 75005 Paris FRX), Apparatus for separating two phases of a sample of heterogeneous liquid by centrifuging, the apparatus being particularl.
Hwang Yean Yow (Cypress CA) Ritchey Brian (Long Beach CA) Schoendorfer Donald W. (Santa Ana CA), Automated blood component separation procedure and apparatus promoting different functional characteristics in multiple.
Blatt William F. (Framingham MA) Agranat Edward A. (Weston MA) Rigopulos Peter N. (Melrose MA), Blood fractionating process and apparatus for carrying out same.
Brown Richard I. (Northbrook IL) Smith Sidney (Lake Forest IL) Cerny David E. (Crystal Lake IL) Foley John T. (Wheeling IL), Centrifugation pheresis system.
Brown Richard I. (Northbrook IL) Smith Sidney (Lake Forest IL) Cerny David E. (Crystal Lake IL) Foley John T. (Wheeling IL), Centrifugation pheresis system.
Brown Richard I. (Northbrook IL) Smith Sidney (Lake Forest IL) Cerny David E. (Crystal Lake IL) Foley John T. (Wheeling IL), Centrifugation system having an interface detection surface.
Galloway Jimmie G. (Missouri City MO) Kelley Lonny R. (Houston TX) Ehrhardt Mark E. (Houston TX) Fowler Tracy A. (Kennewick WA), Centrifuge processor and liquid level control system.
Schoendorfer Donald W. (67 Balboa Coves Santa Ana CA) McLaughlin William F. (67 Balboa Coves Newport Beach CA 92663), Closed hemapheresis system and method.
Rich ; Jr. William E. (Mountain View CA) Smith Frank C. (Felton CA) McNeill Janet L. (Sunnyvale CA), Combination apparatus and method for chromatographic separation and quantitative analysis of multiple ionic species.
Bacehowski David V. (Wildwood IL) Cullis Herbert M. (Silver Spring MD) VanBaelen Armand R. (Rolling Meadows IL), Combination disposable plastic blood receiving container and blood component centrifuge.
Prior Jeffrey J. ; Wallace Donald G. ; Sierra David H. ; DeLustro Frank A., Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof.
Burnouf-Radosevich Miryana (Wavrin FRX) Burnouf Thierry (Wavrin FRX), Concentrate of thrombin coagulable proteins, the method of obtaining same and therapeutical use thereof.
Levine Robert A. (31 Pilgrim La. Guilford CT 06437) Wardlaw Stephen C. (191 N. Cove Rd. Old Saybrook CT 06475), Constitutent layer harvesting from a centrifuged sample in a tube.
Lake William C. (Laguna Niguel CA) Giesler Richard (Deerfield IL) Epps Dennis Van (Cary IL) Chapman John R. (Lake Villa IL) Martinson Jeffrey A. (Mundelein IL) Ellis Dale R. (Wonder Lake IL) Aono Fre, Continuous centrifugation process for the separation of biological components from heterogeneous cell populations.
Schoendorfer Donald W. (Santa Ana CA) Berthe Claude E. (San Dimas CA), Continuous centrifugation system and method for directly deriving intermediate density material from a suspension.
Fischel Richard J. (Minneapolis MN) Brumfield Robert C. (Anaheim CA), Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear.
Bormann Thomas J. (Melville NY) Matkovich Vlado I. (Glen Cove NY) Gsell Thomas C. (Glen Cove NY) Pall David B. (Roslyn Estates NY), Device and method for separating plasma from a biological fluid.
Pall David B. (Glen Cove NY) Gsell Thomas C. (Glen Cove NY) Muellers Brian T. (Rockville Centre NY), Device for processing blood for human transfusion.
Conston Stanley R. (San Carlos CA) Dapper Gregory S. (Newark CA) Murphy Aileen L. (Menlo Park CA) Raeder-Devens Jennifer (Oakland CA) Yamamoto Ronald (San Francisco CA), Embolization plugs for blood vessels.
Kelley Lonny R. ; Ehrhardt Mark E. ; Purewal Mukhtiar S. ; Frederick Jeffrey W. ; Wood ; III Houston G. ; Johnston James P., Flow enhanced one-pass centrifuge separator.
Coleman Charles M. (958 Washington Rd. Pittsburgh PA 15228) Kendrick William (34 Willowbrook Dr. Doylestown PA 18901), Fluid collection, separation and dispensing tube.
Zelmanovic David ; Colella Gregory M. ; Hetherington Edward J. ; Chapman Evelyn Sabrinah ; Paseltiner Lynn, Highly sensitive, accurate, and precise automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples.
O\Donnell ; Jr. Francis E. (6035 Lindell Blvd. St. Louis MO 63112) Nalbandian Robert M. (901 S. Skinker ; Apt. E. Clayton MO 63105) Mammen Eberhard (652 Woods La. Grosse Point Woods MI 48236), Intraocular lens implant and method of locating and adhering within the posterior chamber.
Wolf Stephen J. (Hillsborough NJ) Mart Robert K. (Martinsville NJ) Otto Scott C. (Yardley PA), Locking holder for a pair of syringes and method of use.
hlin L. Erik (Stocksund SEX) Unger H. Peter (Stockholm SEX) Westberg J. Eric (Liding SEX), Method and apparatus for centrifugal batch separation of blood.
Biesel Wolfgang (Ottweiler DEX) Geibel Johannes (Wadern DEX) Brass Henning (Homburg DEX), Method and apparatus for the separation of blood into its components.
Jonsson Svante U. R. (Glumslv SEX), Method and machine based on the principle of centrifugation for cytapheresis such as platelet apheresis, and for plasma.
Cullis Herbert M. (Silver Spring MD) Dorsey Evelyn E. (Washington DC) De Vries James H. (McHenry IL), Method and system for fractionating a quantity of blood into the components thereof.
Rothman Ulf S. E. (Bjrred SEX) Jacobsson Sten A. L. (Malm SEX), Method for cleansing fluid discharging skin surfaces, wounds and mucous membranes and means for carrying out the method.
Rothman, Ulf S. E.; Jacobsson, Sten A. L., Method for cleansing fluid discharging skin surfaces, wounds and mucous membranes and means for carrying out the method.
Philip Henry Coelho ; Phil Kingsley ; Jim Brausch ; James H. Godsey ; Gail Rock CA; Trista K. Madsen ; Sona B. Frausto, Method for preparing thrombin for use in a biological glue.
Pall David B. (Glen Cove NY) Gsell Thomas C. (Glen Cove NY) Muellers Brian T. (Rockville Centre NY), Method for processing blood for human transfusion.
Patat Jean-Louis (Paris FRX) Delmas Olivier (Montbazon FRX) Schmitthaeusler Roland (Montigny-le-Bretonneux FRX), Method of preparing a biological adhesive enriched with platelet factors, and application.
Neumann Hans-Jrgen (St. Wendel DEX) Meisberger Artur (St. Wendel DEX) Weber Wolfram (Spiesen DEX), Method of separating blood and apparatus for carrying out the method.
Williams Stuart K. (Wilmington DE) Jarrell Bruce E. (Philadelphia PA), Method of treating a synthetic naturally occurring surface with a collagen laminate to support microvascular endothelial.
Cawley Leo P. (550 N. Hillside Wichita KS 67214) Bryant Steven A. (550 N. Hillside Wichita KS 67214) Minard Barbara J. (550 N. Hillside Wichita KS 67214), On-line plasma modification means.
Cawley Leo P. (550 N. Hillside Wichita KS) Bryant Steven A. (550 N. Hillside Wichita KS) Minard Barbara J. (550 N. Hillside Wichita KS), On-line plasma modification method.
Fitch ; Jr. Ernest C. (Stillwater OK) Hong Ing T. (Stillwater OK), Orbital separator for separating more dense and less dense components of a mixture having a controllable discharge passa.
Antanavich Richard D. (Paso Robles CA) Dorian Randel (Orinda CA), Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant.
Lin, Chih-Lung; Lee, Ming-Chieh, Predictive image compression using a single variable length code for both the luminance and chrominance blocks for each macroblock.
Michalski Catherine (Lille FRX) Dernis Dominique (Marquette lez Lille FRX), Process for preparing a human thrombin concentrate intended for therapeutic use.
Bui-Khac Trung (Montreal CAX) Lavoie Lise (St-Eustache CAX) Michel St Picq Dominique (Ste-Genevive CAX), Process for the obtention of a biological adhesive made of concentrated coagulation factors by “salting-out”.
Levine Robert A. (Guilford CT) Wardlaw Stephen C. (Old Saybrook CT) Hart Allan H. (Guilford CT), Quantification of fibrinogen in whole blood samples contained in a tube using a float to separate materials.
Kaleskas Edward W. (Jefferson MA) Minior ; Jr. Thaddeus G. (Bedford MA) Nott Sepideh H. (Fall River MA), Rotary centrifuge bowl and seal for blood processing.
Coleman Charles M. (958 Washington Rd. Pittsburgh PA 15228) Kendrick William (34 Willowbrook Dr. Doylestown PA 18901), Separator float and tubular body for blood collection and separation and method of use thereof.
MacPhee Martin James ; Drohan William Nash ; Liau Gene ; Haudenschild Christian, Supplemented and unsupplemented tissue sealants, method of their production and use.
MacPhee Martin James ; Drohan William Nash ; Lasa ; Jr. Carlos I.,PHX ; Liau Gene ; Haudenschild Christian, Supplemented and unsupplemented tissue sealants, methods of their production and use.
MacPhee Martin James ; Drohan William Nash ; Woolverton Christoper J., Supplemented and unsupplemented tissue sealants, methods of their production and use.
Pall David B. (Roslyn Estates NY) Gsell Thomas C. (Glen Cove NY) Matkovich Vlado I. (Glen Cove NY) Bormann Thomas (Seaford NY), System and method for processing biological fluid.
Bennet Richard I. (Crewe GB2) Berthiaume Guy H. (Charlotte NC) Haw Michael F. (Charlotte NC) Melber ; Jr. Joseph G. (Charlotte NC) Neill Jimmie (Sherrilles Ford NC), Thickness sensor comprising a leaf spring means, and a light sensor.
Wells John R. (Galveston TX) Pautsch Gunthard (Oelde DEX) Grabbe Detlef (Ennigerloh DEX) Kohlstette Werner (Oelde DEX), Throughput centrifuge for industrial production of proteins from human blood plasma.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.