IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0297942
(2005-12-09)
|
등록번호 |
US-8099162
(2012-01-17)
|
발명자
/ 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
16 |
초록
▼
The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances
The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances contained in the medium and has an outlet defining a surface, so-called “application surface”, intended to receive a determine part of an eyeball surface, the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball, wherein the outer wall extends from the outer line with a global outwardly with respect to the said optical axis.
대표청구항
▼
1. An ocular iontophoresis device for delivering active substances to an eyeball, the ocular iontophoresis device comprising: an active electrode;a reservoir having a frustoconical shaped outer wall and a hollow body at least partly delimited by the outer wall, the reservoir having an inlet and an o
1. An ocular iontophoresis device for delivering active substances to an eyeball, the ocular iontophoresis device comprising: an active electrode;a reservoir having a frustoconical shaped outer wall and a hollow body at least partly delimited by the outer wall, the reservoir having an inlet and an outlet, the inlet and the outlet each having a respective diameter, wherein the diameter of the inlet is greater than the diameter of the outlet;wherein the outlet defines an application surface adapted to receive a predetermined part of an eyeball surface, wherein an area of the active electrode (“Se”) is greater than an area of the application surface (“Sa”) to provide an increased electric field intensity by a value proportionate to the ratio “Se/Sa”,the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball,wherein the outer wall extends from the outer line outwardly toward the inlet with respect to the optical axis, andwherein the portion of the outer wall delimiting the hollow body has an inclination angle substantially away from the optical axis. 2. An ocular iontophoresis device according to claim 1, wherein the outer line is a loop. 3. An ocular iontophoresis device according to claim 2, wherein the outer line is substantially a circle. 4. An ocular iontophoresis device according to claim 1, wherein the outer wall has a substantially constant inclination angle respective to the optical axis. 5. An ocular iontophoresis device according to claim 2, wherein the outer wall has a substantially constant inclination angle respective to the optical axis. 6. An ocular iontophoresis device according to claim 3, wherein the outer wall has a substantially constant inclination angle respective to the optical axis. 7. An ocular iontophoresis device according to claim 6, wherein the outer wall is tapered around the optical axis. 8. An ocular iontophoresis device according to one of claims 1 to 7, wherein: the application surface is also delimited by an inner line, the reservoir has an inner wall extending from the inner line, and the hollow body is located between the inner wall and the outer wall. 9. An ocular iontophoresis device according to claim 8, wherein the inner line is concave towards the optical axis. 10. An ocular iontophoresis device according to claim 9, wherein the inner line is a loop. 11. An ocular iontophoresis device according to claim 10, wherein the inner line is substantially a circle. 12. An ocular iontophoresis device according to claim 8, wherein the inner wall extends from the inner line outwardly with respect to the optical axis of the eyeball once the ocular iontophoresis device is put on the eyeball. 13. An ocular iontophoresis device according to claim 12, wherein the inner wall has a substantially constant inclination angle respective to the optical axis. 14. An ocular iontophoresis device according to claim 13, wherein the inner wall is tapered around the optical axis. 15. An ocular iontophoresis device according to claim 9, wherein the inner wall extends from the inner line outwardly with respect to the optical axis. 16. An ocular iontophoresis device according to claim 15, wherein the outer wall has a substantially constant inclination angle with respect to the optical axis. 17. An ocular iontophoresis device according to claim 16, wherein the inner wall is tapered around the optical axis. 18. An ocular iontophoresis device according to claim 1, wherein the application surface is designed for covering at least a portion of the cornea of the eyeball. 19. An ocular iontophoresis device according to claim 1, wherein the application surface is designed for covering at least a portion of the cornea of the eyeball and at least a portion of the sclera of the eyeball. 20. An ocular iontophoresis device according to claim 1, wherein the application surface is designed for covering at least a portion of the sclera of the eyeball. 21. An ocular iontophoresis device according to claim 20, wherein the application surface is designed for covering in projection at least a portion of the ciliary body of the eyeball. 22. An ocular iontophoresis device according to claim 21, wherein the application surface is designed for covering in projection at least a portion of the anterior pars plicata ciliaris of the eyeball. 23. An ocular iontophoresis device according to claim 21, wherein the application surface is designed for covering in projection at least a portion of the posterior pars plana ciliaris of the eyeball. 24. An ocular iontophoresis device according to one of claims 21 to 23, wherein the outer wall is tapered around the optical axis with an inclination angle in the range from around 30 degree to around 40 degree. 25. An ocular iontophoresis device according to claim 8, wherein the inner wall is tapered around the optical axis and extends outwardly from the application surface with respect to the optical axis with a substantially constant inclination angle with respect to the optical axis of about 0 degree. 26. An ocular iontophoresis device according to claim 1, wherein the reservoir comprises: a first container for containing active substances and the electrically conductive medium; and a second container for containing electrically conductive elements; wherein the first and second containers are separated by a semi-permeable membrane permeable to the electrically conductive elements and non-permeable to the active substances. 27. An ocular iontophoresis device according to claim 1, wherein the outer wall of the reservoir has flexible front portions to be put on the eyeball, and wherein the outer wall of the reservoir has reinforced or rigid rear portions extending from the flexible front portions. 28. An ocular iontophoresis device according to claim 27, wherein the flexible front portions of the outer wall are progressively more rigid extending further away from the application surface. 29. An ocular iontophoresis device according to claim 28, wherein the flexible front portions of the outer wall are progressively thicker extending further away from the application surface, thereby achieving progressively-varying rigidity. 30. An ocular iontophoresis device according to one of claims 27 to 29, wherein the flexible front portions of the outer wall form a barrier to at least one of current leaking out from the reservoir and intrusion of outer contaminants into the reservoir. 31. An ocular iontophoresis device according to claim 1, wherein the reservoir contains a plurality of internal walls extending from the outer wall to define tight compartments. 32. An ocular iontophoresis device according to claim 1, further comprising an electrically conductive medium, wherein the electrically conductive medium is selected from the group consisting of an electrically conductive liquid and a gel. 33. An ocular iontophoresis device according to one of claims 21 to 23, wherein the electrically conductive medium includes active principles that are selected from the group consisting of: beta blockers including at least one of betaxolol, levobunolol, timolol, carteolol, befunolol, or metipranolol; alpha adrenergic agonists including at least one of brimonidine, apraclonidine, or dipivefrine; carbonic anhydrase inhibitors including at least one of dorzololamide, brinzolamide, acetazolamide, of methazolamide; non-specific adrenergic agonists or sympathomimetic agents including at least one of epinephrine, phenylephrine, dipevefrin, or apraclonidine; cholinergic agonists (anticholinesterase agents) or parasympathomimetics including at least one of pilocarpine, carbachol, aceclidine, or echothiopathe; and prostaglandin analogues including at least one of latanoprost, bimatoprost, or travoprost. 34. An ocular iontophoresis device according to claim 1, wherein the active electrode has globally the same shape as the bottom of the hollow body. 35. An ocular iontophoresis device according to claim 1, wherein the active electrode includes a through opening. 36. An ocular iontophoresis device according to claim 1, wherein the active electrode is arranged, in operation, to present current density of less than 10 mA/cm2 and to be polarized for around 10 minutes. 37. An ocular iontophoresis device according to claim 1, wherein the reservoir further includes an end wall which closes the bottom of the hollow body on which the active electrode is manufactured. 38. An ocular iontophoresis device according to claim 37, wherein the active electrode is formed directly on the end wall of the reservoir by a process selected from the group consisting of: electroplating; depositing an ink of an electrically conductive material; depositing a solid film filled with an electrically conductive material; overmolding polymers filled with an electrically conductive material to form conductive layers; and depositing one wire of electrically conductive material. 39. An ocular iontophoresis device according to claim 1, wherein the active electrode is substantially parallel to the application surface. 40. An ocular iontophoresis device according to claim 1, further comprising: a rigid rear part, wherein the active electrode is located between the rigid rear part and the reservoir. 41. An ocular iontophoresis device according to claim 8, wherein the inner wall is tapered around the optical axis and extends outwardly from the application surface with respect to the optical axis with a substantially constant inclination angle with respect to the optical axis in the range from around 30 degree to around 40 degree. 42. An ocular iontophoresis device according to claim 1, further comprising an electrically conductive medium. 43. An ocular iontophoresis device according to claim 1, further comprising active substances. 44. An ocular iontophoresis device according to claim 43, wherein the active substances comprising a medication, a drug, or any combination thereof.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.