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[미국특허] Methods and devices for microfluidic point-of-care immunoassays 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12M-001/36
출원번호 US-0341637 (2008-12-22)
등록번호 US-8110392 (2012-02-07)
발명자 / 주소
  • Battrell, C Frederick
  • Gerdes, John
  • Mordue, Stephen
  • Capodanno, Jason
  • Hoekstra, Denise Maxine
  • Williford, John R
  • Clemmens, John
출원인 / 주소
  • Micronics, Inc.
대리인 / 주소
    Seed IP Law Group PLLC
인용정보 피인용 횟수 : 37  인용 특허 : 37

초록

Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.

대표청구항 ▼

1. A microfluidic card for performing an immunoassay, the microfluidic card comprising an on-board waste fluid isolation apparatus, said on-board waste fluid isolation apparatus comprising: a) a plastic body having an external surface and encasing a waste receiving reservoir, said reservoir having a

이 특허에 인용된 특허 (37) 인용/피인용 타임라인 분석

  1. Gordon Gary B., Apparatus for biomolecular array hybridization facilitated by agitation during centrifuging.
    상세보기
  2. Gribnau Thomas C. J. (Haren NLX) Roeles Frits (Dreumel NLX) Leuvering Johannes H. W. (Heesch NLX), Application of water-dispersible hydrophobic dyes or pigments as labels in immunoassays.
    상세보기
  3. Levin Andrew E. (10 Gay Rd. Watertown MA 02172), Binding assay device with removable cassette and manifold.
    상세보기
  4. Besemer Donald M. ; Goss Virginia W. ; Winkler James L., Bioarray chip reaction apparatus and its manufacture.
    상세보기
  5. Sasse Edward A. (Brookfield WI) Yorde Donald E. (Milwaukee WI), Competitive enzyme-linked immunoassay.
    상세보기
  6. Tom Henry K. (La Honda CA) Rowley Gerald L. (Cupertino CA), Concentrating zone method in heterogeneous immunoassays.
    상세보기
  7. Pelrine,Ronald E.; Kornbluh,Roy D., Devices and methods for controlling fluid flow using elastic sheet deflection.
    상세보기
  8. Van de Goor, Tom; Brennen, Reid A., Devices and methods for fluid mixing.
    상세보기
  9. Jou Yi-Her (Libertyville IL) Stroupe Stephen D. (Libertyville IL) Markese James J. (Libertyville IL), Devices for performing ion-capture binding assays.
    상세보기
  10. Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
    상세보기
  11. Oberhardt Bruce (Raleigh NC), Immunoassay system using forced convection currents.
    상세보기
  12. de Jaeger Nikolaas C. J. (Hove BEX) Monbaliu Marcel J. (Mortsel BEX) Noppe Marcus J. M. (Kalmthout BEX) Konings Frank J. (Antwerpen BEX), Immunoassay using colorable latex particles.
    상세보기
  13. Tarcha Peter J. (Lake Villa IL) Donovan James J. (Waukegan IL) Wong Martin (Grayslake IL), Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles.
    상세보기
  14. Anderson Rolfe C. ; Lipshutz Robert J. ; Rava Richard P. ; Fodor Stephen P. A., Integrated nucleic acid diagnostic device.
    상세보기
  15. Imrich Michael R. (Encinitas CA) Zeis John K. (San Diego CA) Miller Steven P. (San Diego CA) Pronovost Allan D. (San Diego CA), Lateral flow medical diagnostic assay device with sample extraction means.
    상세보기
  16. Cottingham Hugh V. (Caldwell NJ), Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay.
    상세보기
  17. McNeely,Michael; Adey,Nils; Spute,Mark; Ayliffe,Edward; Howard,Michael; Beutel,Darin; Jensen,John; Coffin,Stephen; Moyer,Thomas, Method and system for microfluidic interfacing to arrays.
    상세보기
  18. Vischer, Peter; Aeschilmann, Marcel, Method for processing a nucleic acid sample by swinging a segment of a cartridge wall, a system and a cartridge for performing such a method.
    상세보기
  19. Anderson Rolfe C. ; Lipshutz Robert J. ; Rava Richard P. ; Fodor Stephen P. A., Method of manipulating a gas bubble in a microfluidic device.
    상세보기
  20. Rapp Richard,DEX ; Kalb Helmut,DEX ; Stark Walter,DEX ; Seidel Dieter,DEX ; Biedermann Hans,DEX, Micro diaphragm pump.
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  21. Bernhard H. Weigl ; Gerald L. Klein ; Ronald L. Bardell ; Clinton L. Williams ; Thomas H. Schulte, Microfluidic analysis cartridge.
    상세보기
  22. Hayenga,Jon W.; Weigl,Bernhard H.; Bardell,Ronald L.; Morris,Christopher J., Microfluidic channel network device.
    상세보기
  23. O'Connor, Stephen D.; Karp, Christoph D.; Pezzuto, Marci; Patel, Paren P.; Hobbs, Steven E.; Dantsker, Eugene, Microfluidic synthesis devices and methods.
    상세보기
  24. Weigl, Bernhard H.; Yager, Paul; Kamholz, Andrew; Hatch, Anson, Microscale diffusion immunoassay.
    상세보기
  25. Anderson Rolfe C. ; Lipshutz Robert J. ; Rava Richard P. ; Fodor Stephen P. A., Miniaturized genetic analysis systems and methods.
    상세보기
  26. Johnny Svensson SE; Bertil Nilsson SE; Per Olsson SE; Lars Jansson SE, Mixing method.
    상세보기
  27. Craig Stephen R., Multilayer integrated assembly having an integral microminiature valve.
    상세보기
  28. Kuo, Yuan-Fong; Yao, Nan-Kuang; Wu, Jhy-Wen; Shia, Tim; Parng, Shaw-Hwa, Partially closed microfluidic system and microfluidic driving method.
    상세보기
  29. Cole Francis X. (Stow MA) Sigillo Eric C. (Methuen MA) MacDonnell Paul C. (Bedford MA) Cicia Nancy J. (Wakefield MA), Porous strip form assay device method.
    상세보기
  30. Maier ; Jr. ; Charles L., Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids.
    상세보기
  31. Weigl, Bernhard H.; Williams, Clinton L.; Hayenga, Jon W.; Bardell, Ronald L.; Schulte, Thomas E., Pumpless microfluidics.
    상세보기
  32. Levin Andrew E. ; Bowers William, Rapid flow-through binding assay apparatus and method therefor.
    상세보기
  33. Brown ; III William E. (Grayslake IL) Safford Sarah E. (Libertyville IL) Clemens John M. (Gurnee IL), Solid-phase analytical device and method for using same.
    상세보기
  34. Frye Ward Kevin ; Freudenthal Jacob Koppel ; LaBelle Terri Christina ; Young Eugene, System and method for filling a substrate with a liquid sample.
    상세보기
  35. Craig Alan R. (Wilmington DE) Hartz ; Jr. Thomas P. (Newark DE), Use of polyoxyethylene ethers to improve the performance of immunoassays employing peroxidase conjugates.
    상세보기
  36. Jon W. Hayenga ; Clinton L. Williams, Valve for use in microfluidic structures.
    상세보기
  37. Williams, Clinton L., Valve for use in microfluidic structures.
    상세보기

이 특허를 인용한 특허 (37) 인용/피인용 타임라인 분석

  1. Wright, David Walter; Aiello, Dominic; Clark, Robert, Apparatus and methods for manipulating deformable fluid vessels.
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  2. Schubert, Axel; Bels, Kevin, Apparatus for determining at least one evaluation parameter of a blood sample.
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  3. Wright, David Walter; Aiello, Dominic, Apparatus, devices, and methods for manipulating deformable fluid vessels.
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  4. Gorin, Michael; Hillman, Robert S.; McCluskey, Cory Lee; Schwaiger, Hubert Martin, Blood testing system.
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  5. McCluskey, Cory Lee; Hillman, Robert S.; Gorin, Michael; Schwaiger, Hubert Martin, Blood testing system and method.
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  6. Gorin, Michael; Hillman, Robert S.; McCluskey, Cory Lee, Body fluid cartridge device.
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  7. Schubert, Axel; Romero-Galeano, Jose J.; Kessler, Max, Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method.
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  8. Schubert, Axel; Romero-Galeano, Jose J.; Kessler, Max, Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method.
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  9. Schubert, Axel; Romero-Galeano, José Javier; Kessler, Max, Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method.
    상세보기
  10. Schubert, Axel; Romero-Galeano, José Javier; Kessler, Max, Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method.
    상세보기
  11. Schubert, Axel; Romero-Galeano, José Javier; Kessler, Max, Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method.
    상세보기
  12. Schubert, Axel; Romero-Galeano, José Javier; Kessler, Max, Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method.
    상세보기
  13. Schubert, Axel; Romero-Galeano, José Javier; Kessler, Max, Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method.
    상세보기
  14. Briman, Mikhail, Cartridge for diagnostic testing.
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  15. Briman, Mikhail, Cartridge for diagnostic testing.
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  16. Wright, David Walter; Aiello, Dominic; Kroehl, Peter; Kayyem, Jon Faiz; Gray, Darren Scott, Cartridge for performing assays in a closed sample preparation and reaction system.
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  17. Tang, Hamilton R.; De La Zerda, Adam; Li, Kenneth I.; Limtao, Kevin M.; Baldwin, Alan D.; Loney, Gregory C., Cartridge-based thermocycler.
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  18. Briman, Mikhail, Controlled electrochemical activation of carbon-based electrodes.
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  19. Lofquist, Alan K.; Battrell, C. Frederick; Bouzek, Heather K., Device for preparation and analysis of nucleic acids.
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  20. Wright, David Walter; Aiello, Dominic, Devices and methods for manipulating deformable fluid vessels.
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  21. Andreyev, Boris; Chu, Steven; Ciopyk, Brian; De La Zerda, Adam; Huang, Helen; Loney, Gregory; Swenson, David D., Devices and methods for molecular diagnostic testing.
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  22. Andreyev, Boris; Moravick, Keith E.; Ciopyk, Brian; Briones, Victor; Loney, Gregory; De La Zerda, Adam; Ching, Jesus; Chu, Steven; Swenson, David; Huang, Helen, Devices and methods for molecular diagnostic testing.
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  23. Andreyev, Boris; Moravick, Keith E.; Ciopyk, Brian; Briones, Victor; Loney, Gregory; de la Zerda, Adam; Ching, Jesus; Chu, Steven; Swenson, David; Huang, Helen, Devices and methods for molecular diagnostic testing.
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  24. Andreyev, Boris; Moravick, Keith E.; Ciopyk, Brian; Briones, Victor; Loney, Gregory; de la Zerda, Adam; Ching, Jesus; Kelly, Colin; Chu, Steven; Swenson, David; Huang, Helen, Devices and methods for molecular diagnostic testing.
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  25. Kolb, Andrew; Sprague, Isaac; Kay, Justin L.; Bragd, Matthew Scott; Stone, Martha, Fluidic circuits and related manufacturing methods.
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  26. Kayyem, Jon Faiz; Ford, Sean; Pamula, Vamsee K.; Srinivasan, Vijay; Corey, Scott; Murphy, Brian; Wright, David Walter; Aiello, Dominic, Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation.
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  27. Corey, Scott; Murphy, Brian; Schneider, Eric; Wright, David Walter; Aiello, Dominic; Fish, Andrew; Srinivasan, Jay; Maltezos, George, Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system.
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  28. Esfandiari, Javanbakhsh, Integrated buffer dual-path immunoassay device.
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  29. Kayyem, Jon Faiz; Srinivasan, Jayashankar; Ford, Sean, Integrated multiplex target analysis.
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  30. Battrell, C. Frederick; Gerdes, John; Williford, John R.; Hoekstra, Denise Maxine; Breidford, Wayne L.; Mordue, Stephen; Clemmens, John; Nabavi, Melud; Kokoris, Mark, Integrated nucleic acid assays.
    상세보기
  31. Schubert, Axel; Romero-Galeano, José Javier; Kessler, Max, Measuring unit for measuring characteristics of a sample liquid, in particular viscoelastic characteristics of a blood sample.
    상세보기
  32. Schubert, Axel; Bels, Kevin, Method for determining at least one evaluation parameter of a blood sample.
    상세보기
  33. Viola, Francesco; Walker, William F.; Browne, Gregory V.; Magyar, Robert S.; Hansen, Bjarne; Denny, Christopher G., Methods for evaluation of hemostasis.
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  34. Bouzek, Heather K., Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions.
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  35. Clemmens, John; Battrell, C. Frederick; Gerdes, John; Hoekstra, Denise Maxine, Microfluidic mixing and analytical apparatus.
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  36. Battrell, C. Frederick; Sprague, Isaac; Bragd, Matthew Scott; Capodanno, Jason, Sample-to-answer microfluidic cartridge.
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  37. Dahl, Steven David; Parsons, Sean Andrew; Maschmann, Jennifer; Wong, Kon Euan Gerard; Spink, Tim Ian; Wilson, Stephen Robert, Sampling and testing device for the human or animal body.
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