IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0986727
(2007-11-26)
|
등록번호 |
US-8113837
(2012-02-14)
|
발명자
/ 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
15 인용 특허 :
39 |
초록
▼
An oral appliance is provided for delivering a medicament to at least a portion of teeth and/or soft tissue areas inside a mouth, the oral appliance having an interior surface having a porous material disposed on at least a portion of the interior surface of the oral appliance, the porous material c
An oral appliance is provided for delivering a medicament to at least a portion of teeth and/or soft tissue areas inside a mouth, the oral appliance having an interior surface having a porous material disposed on at least a portion of the interior surface of the oral appliance, the porous material containing a medicament and the interior surface being formed to fit contours of at least the portion of the teeth and/or soft tissue areas inside the mouth and being capable of supporting and holding the porous material in contact with at least the portion of the teeth and/or soft tissue areas inside the mouth to deliver the medicament.
대표청구항
▼
1. An oral appliance for delivering a medicament to teeth and soft tissue areas inside a mouth, the oral appliance being custom fit to the mouth and comprising a non-porous exterior surface that prevents the medicament from being diluted by saliva and an interior surface having a porous material dis
1. An oral appliance for delivering a medicament to teeth and soft tissue areas inside a mouth, the oral appliance being custom fit to the mouth and comprising a non-porous exterior surface that prevents the medicament from being diluted by saliva and an interior surface having a porous material disposed on at least a portion of the interior surface of the oral appliance, the porous material comprising a sponge or foam pre-filled with one or more doses of the medicament and the interior surface being custom fit and formed to fit contours of the teeth and soft tissue areas inside the mouth and being capable of supporting and holding the porous material to deliver the medicament, wherein the interior surface is formed from a hard thermoplastic material molded to correspond to the contours of the teeth and soft tissue areas inside the mouth and the porous material is supported and held within a cargo area of the interior surface of the thermoplastic material of the oral appliance and the cargo area is continuous and is configured to extend adjacent to the gums and all the teeth and the sponge or foam is a single continuous piece disposed in the cargo area and is configured to extend, along a length of the sponge or foam, from buccal surfaces of the teeth and surrounding gingival tissue, over occlusal surfaces of the teeth, over lingual surfaces of the teeth, and over adjacent gingival tissue on a lingual side of the teeth and the sponge or foam has a surface that corresponds to the cargo area and the sponge or foam has a portion having increased thickness, extending in a direction transverse to the length of the sponge or foam, that is complementary to and locks into the cargo area. 2. An oral appliance according to claim 1, wherein the soft tissue areas inside the mouth include muco-buccal folds, hard palate, soft palate, lining mucosa, attached gingival tissue, and mouth floor tissue. 3. An oral appliance according to claim 1, wherein the medicament is configured to be delivered to the buccal surfaces, surrounding gingival tissue, occlusal surfaces, the lingual surfaces, and adjacent gingival tissue on the lingual side of the teeth. 4. An oral appliance according to claim 1, wherein the medicament is configured to be delivered to the soft tissue and teeth at or near a gingival margin or sulcus. 5. An oral appliance according to claim 1, wherein at least one of: (i) the porous material has a depth of from about 1 mm to about 5 mm; (ii) the porous material has a width of from about 1 mm to about 10 mm; or (iii) the oral appliance has a thickness of from about 0.06 inches to about 0.2 inches. 6. An oral appliance according to claim 1, wherein the porous material is configured to deliver the medicament to the gingival margin. 7. An oral appliance according to claim 1, wherein the porous material is configured to deliver the medicament to: (i) a muco-gingival junction; (ii) at least 2 mm to 5 mm buccally beyond a gingival margin; or (iii) at least 2 mm to 5 mm lingually beyond a gingival margin. 8. An oral appliance according to claim 1, wherein the porous material is configured to deliver at least one of (i) a bolus dose of the medicament; (ii) a single dose of the medicament; or (iii) multiple doses of the medicament. 9. An oral appliance according to claim 1, wherein the sponge or foam comprises a cushion zone. 10. An oral appliance according to claim 1, wherein the medicament comprises at least one analgesic, whitening agent, breath freshener, anti-inflammatory, anticalculus agent, antimicrobial, anesthetic, muscle relaxant, selective H-2 antagonists, anticaries agent, nutrient, vitamin, mineral, herbal product, or mixtures thereof. 11. An oral appliance according to claim 1, wherein the oral appliance is constructed from a digital data set. 12. An oral appliance according to claim 1, wherein the oral appliance is constructed from a digital data set or a physical model thereof representing all of the teeth and soft tissue areas inside the mouth. 13. An oral appliance according to claim 1, wherein the porous material is saturated with liquid medicament for optimum flow to deliver the medicament. 14. An oral appliance for delivering a medicament according to claim 1, wherein the sponge or foam is compressible to release the medicament. 15. An oral appliance according to claim 1, wherein the oral appliance is configured to deliver medicament to the gums. 16. A method of delivering medicament to teeth and soft tissue areas inside a mouth, the method comprising: providing an oral appliance comprising a non-porous exterior surface that prevents medicament from being diluted by saliva and an interior surface and a porous material disposed on at least a portion of the interior surface of the oral appliance and, the porous material comprising a sponge or foam pre-filled with one or more doses of medicament, the interior surface formed to fit contours of the teeth and soft tissue areas inside the mouth and being capable of holding the porous material; andcovering the teeth and soft tissue areas inside the mouth with the oral appliance holding the porous material to deliver the medicament, wherein the interior surface is formed from a hard thermoplastic material molded to correspond to the contours of the teeth and soft tissue areas inside the mouth and the porous material is supported and held within a cargo area of the interior surface of the thermoplastic material of the oral appliance and the cargo area is continuous and extends adjacent to the gums and all the teeth and the sponge or foam is a single continuous piece disposed in the cargo area and extends, along a length of the sponge or foam, from buccal surfaces of the teeth and surrounding gingival tissue, over occlusal surfaces of the teeth, over lingual surfaces of the teeth, and over adjacent gingival tissue on a lingual side of the teeth and the sponge or foam has a surface that corresponds to the cargo area and the sponge or foam has a portion having increased thickness, extending in a direction transverse to the length of the sponge or foam, that is complementary to and locks into the cargo area. 17. A method according to claim 16, further comprising maintaining inside the mouth for a sufficient time to allow a therapeutically effective amount of the medicament to be delivered. 18. A method according to claim 16, wherein the medicament comprises at least one analgesic, whitening agent, anti-inflammatory, anticalculus agent, antimicrobial, anesthetic, selective H-2 antagonists, anticaries agent, nutrient, vitamin, mineral, herbal product, or mixtures thereof. 19. A method according to claim 16, wherein the medicament comprises at least one systemic drug. 20. A method of delivering medicament to teeth and soft tissues areas inside a mouth, the method comprising: providing an oral appliance, the oral appliance being custom fit by a dental provider to the mouth of a patient, the oral appliance comprising a non-porous exterior surface that prevents medicament from being diluted by saliva and an interior surface and a porous material disposed on at least a portion of the interior surface of the oral appliance, the porous material comprising a custom fit sponge or foam prescribed by the dental provider and pre-filled with one or more doses of medicament, the interior surface being formed to fit contours of the teeth and soft tissue areas inside the mouth and being capable of holding the porous material; andcovering the teeth and soft tissue areas inside the mouth with the oral appliance to deliver the medicament, the porous material being a single continuous piece disposed in a cargo area and extends, along a length of the sponge or foam, from buccal surfaces of the teeth and surrounding gingival tissue, over occlusal surfaces of the teeth, over lingual surfaces of the teeth, and over adjacent gingival tissue on a lingual side of the teeth, wherein the interior surface comprises a hard thermoplastic material molded to correspond to the contours of the teeth and soft tissue areas inside the mouth and the porous material is supported and held within the cargo area of the interior surface of the thermoplastic material of the oral appliance and the sponge or foam has a surface that corresponds to the cargo area and the sponge or foam has a portion having increased thickness, extending in a direction transverse to the length of the sponge or foam, that is complementary to and locks into the cargo area. 21. A method of delivering medicament according to claim 20, wherein the dental provider is a dentist. 22. An oral appliance for delivering a medicament to all teeth inside a mouth, the oral appliance comprising a non-porous exterior surface that prevents the medicament from being diluted by saliva and an interior surface having a porous material disposed on at least a portion of the interior surface of the oral appliance, the porous material comprising a sponge or foam pre-filled with one or more doses of the medicament and the interior surface being capable of supporting and holding the porous material in contact with all the teeth inside the mouth to deliver the medicament, wherein the interior surface is formed from a hard thermoplastic material molded to correspond to the contours of at least all the teeth and the porous material is supported and held within a cargo area of the interior surface of the thermoplastic material of the oral appliance and the cargo area is continuous and is configured to extend adjacent to all the teeth and the sponge or foam is a single continuous piece disposed in the cargo area and is configured to extend, along a length of the sponge or foam, over the front, back and occlusal surfaces of all the teeth and the sponge or foam has a surface that corresponds to the cargo area and the sponge or foam has a portion having increased thickness, extending in a direction transverse to the length of the sponge or foam, that is complementary to and locks into the cargo area. 23. An oral appliance according to claim 22, wherein the porous material is configured to deliver at least one of (i) a bolus dose of the medicament; (ii) a single dose of the medicament; or (iii) multiple doses of the medicament. 24. An oral appliance for delivering a medicament to all the teeth and adjacent buccal and lingual tissue inside a mouth, the oral appliance comprising a non-porous exterior surface that prevents the medicament from being diluted by saliva and an interior surface having a porous material disposed on at least a portion of the interior surface of the oral appliance, the porous material comprising a sponge or foam pre-filled with one or more doses of the medicament and the interior surface being capable of supporting and holding the porous material in contact with all the teeth and adjacent buccal and lingual tissue inside the mouth to deliver the medicament, wherein the interior surface is formed from a hard thermoplastic material molded to correspond to the contours of all the teeth and adjacent buccal and lingual tissue inside the mouth and the porous material is supported and held within a cargo area of the interior surface of the thermoplastic material of the oral appliance and the cargo area is continuous and is configured to extend adjacent to all the teeth and adjacent buccal and lingual tissue and the porous material is a single continuous piece disposed in the cargo area and is configured to cover all the teeth and is configured to extend, along a length of the sponge or foam, to adjacent buccal and lingual tissue across occlusal surfaces of all the teeth and the sponge or foam has a surface that corresponds to the cargo area and the sponge or foam has a portion having increased thickness, extending in a direction transverse to the length of the sponge or foam, that is complementary to and locks into the cargo area. 25. An oral appliance according to claim 24, wherein the porous material is configured to deliver at least one of (i) a bolus dose of the medicament; (ii) a single dose of the medicament; or (iii) multiple doses of the medicament.
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