Enhanced biological autologous tissue adhesive composition and methods of preparation and use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/36
A61M-005/00
A61M-031/00
A61M-037/00
출원번호
US-0181677
(2005-07-14)
등록번호
US-8124075
(2012-02-28)
발명자
/ 주소
Burkinshaw, Brian D.
Whitlock, Steven I.
Rogan, James B.
Devries, Gerald L.
출원인 / 주소
Spinal Restoration, Inc.
대리인 / 주소
O'Keefe, Egan, Peterman & Enders, LLP
인용정보
피인용 횟수 :
0인용 특허 :
47
초록▼
The invention includes a composition useful for preparing a tissue sealant for use on a patient, comprising: autologous fibrinogen, an activating agent and at least one supplement. The invention includes a method of treating a disc having at least one defect, comprising: introducing a composition in
The invention includes a composition useful for preparing a tissue sealant for use on a patient, comprising: autologous fibrinogen, an activating agent and at least one supplement. The invention includes a method of treating a disc having at least one defect, comprising: introducing a composition into the disc, wherein the composition comprises autologous fibrinogen and an activating agent, and wherein the composition forms fibrin.
대표청구항▼
1. A method of treating tissue of a patient wherein the tissue is a disc that has at least one defect, comprising: inserting a needle through skin and into the disc, injecting a composition through the needle into the disc using a trigger-activated delivery gun to deliver a measured dose of the comp
1. A method of treating tissue of a patient wherein the tissue is a disc that has at least one defect, comprising: inserting a needle through skin and into the disc, injecting a composition through the needle into the disc using a trigger-activated delivery gun to deliver a measured dose of the composition with each pull of the trigger, wherein the gun has the needle affixed thereto, wherein the gun includes a tip such that mixing of the composition occurs prior to the composition contacting the disc, wherein the composition comprises at least one supplement, a contrast medium, autologous fibrinogen and a snake venom effective to convert the autologous fibrinogen to fibrin, and wherein the composition forms fibrin. 2. The method of claim 1, wherein the at least one supplement is selected from the group consisting of analgesics, anesthetics, antimicrobial compounds, antibiotics, antifibrinolytic agents, anti-inflammatory compounds, antibodies, anticoagulants, antifungal compounds, antiangiogenins, antiseptics, cardiovascular drugs, cytokines, cytotoxins or cell proliferation inhibiting compounds, chemotherapeutic drugs, interferons, growth factors, hormones, lipids or liposomes, oligonucleotides or polynucleotides, osteoinducers, cartilage-inducing compounds, polymers, polysaccharides, proteoglycans, polypeptides, protease inhibitors, steroids, vasoconstrictors, vasodilators, vitamins, nutritional supplements, minerals, stabilizers and combinations thereof. 3. The method of claim 1, wherein the at least one supplement is an anesthetic. 4. The method of claim 1, wherein the at least one supplement is growth hormone. 5. The method of claim 1, wherein the disc has at least one defect in the annulus fibrosus.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (47)
Redl Heinz (Vienna ATX) Kriwetz Gert (Graz ATX), Apparatus for applying a tissue adhesive on the basis of human or animal proteins.
Drohan William N. ; MacPhee Martin J. ; Miekka Shirley I. ; Singh Manish S. ; Elson Clive,CAX ; Taylor ; Jr. John R., Chitin hydrogels, methods of their production and use.
Prior Jeffrey J. ; Wallace Donald G. ; Sierra David H. ; DeLustro Frank A., Compositions containing thrombin and microfibrillar collagen and methods for preparation and use thereof.
Brown Ross G. (Terre Haute IN) Bright David R. (Terre Haute IN) Williams Robert D. (Terre Haute IN), Fibrin binder/carrier for active biochemical agents.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Fibrin sealant compositions and methods for utilizing same.
Burgess, Willson H.; Greisler, Howard P.; Drohan, William N.; Maciag, Thomas; MacPhee, Martin J., Method of preparing a tissue sealant-treated biomedical material.
Miekka Shirley I. ; Drohan William N. ; Jameson Thomas R. ; Singh Manish P. ; Taylor ; Jr. John R. ; MacPhee Martin J., Methods of production and use of liquid formulations of plasma proteins.
Miekka Shirley I. ; Drohan William N. ; Jameson Thomas R. ; Taylor ; Jr. John R. ; Singh Manish S., Methods of production and use of liquid formulations of plasma proteins.
Miekka, Shirley I.; Drohan, William N.; Jameson, Thomas R.; Taylor, Jr., John R.; Singh, Manish P.; MacPhee, Martin J., Methods of production and use of liquid formulations of plasma proteins.
Antanavich Richard D. (Paso Robles CA) Dorian Randel (Orinda CA), Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant.
Hegasy Ahmed (Leverkusen DEX) Ramsch Klaus-Dieter (Heerlen NLX), Solid medicament formulations containing nifedipine, and processes for their preparation.
MacPhee Martin James ; Drohan William Nash ; Liau Gene ; Haudenschild Christian, Supplemented and unsupplemented tissue sealants, method of their production and use.
MacPhee Martin James ; Drohan William Nash ; Lasa ; Jr. Carlos I.,PHX ; Liau Gene ; Haudenschild Christian, Supplemented and unsupplemented tissue sealants, methods of their production and use.
MacPhee Martin James ; Drohan William Nash ; Woolverton Christoper J., Supplemented and unsupplemented tissue sealants, methods of their production and use.
Luck Edward E. (Menlo Park CA) Brown Dennis M. (Menlo Park CA), Treatments employing drug-containing matrices for introduction into cellular lesion areas.
Luck Edward E. (Menlo Park CA) Brown Dennis M. (Menlo Park CA), Treatments employing drug-containing matrices for introduction into cellular lesion areas.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.